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BRIEF TITLE: A Prospective Phase II Trial of Neoadjuvant Systemic Chemotherapy Followed by Extirpative Surgery for Patients With High Grade Upper Tract Urothelial Carcinoma

A Prospective Phase II Trial of Neoadjuvant Systemic Chemotherapy Followed by Extirpative Surgery for Patients With High Grade Upper Tract Urothelial Carcinoma


  • Org Study ID: EA8141
  • Secondary ID: NCI-2014-02267,EA8141,EA8141,U10CA180820
  • NCT ID: NCT02412670
  • NCT Alias:
  • Sponsor: ECOG-ACRIN Cancer Research Group - Other
  • Source: Eastern Cooperative Oncology Group

Brief Summary

This phase II trial studies how well giving chemotherapy before surgery works in treating patients with aggressive upper urinary tract cancer. Drugs used in chemotherapy, such as methotrexate, vinblastine, doxorubicin hydrochloride, cisplatin, gemcitabine hydrochloride, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Removing the affected upper urinary tract by surgery is the recommended treatment for upper urinary tract cancer, but can cause loss of kidney function and prevent patients from being able to receive chemotherapy after surgery. Giving chemotherapy before surgery, when the kidneys are working at their maximum, may allow less tissue to be removed during surgery and may be more effective in treating patients with high grade upper urinary tract cancer.

Detailed Description


PRIMARY OBJECTIVES:

I. To evaluate the rate of complete pathologic response (pCR = pT0pN0) as assessed by
standard pathologic review attained by neoadjuvant systemic chemotherapy and
nephroureterectomy.

SECONDARY OBJECTIVES:

I. To evaluate the safety of neoadjuvant systemic chemotherapy in patients with upper tract
urothelial carcinoma preceding nephroureterectomy.

II. To evaluate recurrence-free survival of patients treated with neoadjuvant systemic
chemotherapy preceding nephroureterectomy.

III. To evaluate event-free survival of patients treated with neoadjuvant systemic
chemotherapy preceding nephroureterectomy.

IV. To evaluate bladder cancer-free survival of patients treated with neoadjuvant systemic
chemotherapy preceding nephroureterectomy.

V. To evaluate cancer specific survival of patients treated with neoadjuvant systemic
chemotherapy preceding nephroureterectomy.

VI. To evaluate renal functional outcomes of patients treated with neoadjuvant systemic
chemotherapy preceding nephroureterectomy.

TERTIARY OBJECTIVES:

I. To collect pre-treatment and post-treatment tumor tissue, peripheral blood mononuclear
cell (PBMC), peripheral blood plasma, and urine specimens for potential evaluations of
markers of chemotherapy response/resistance.

OUTLINE: Patients are assigned to 1 of 2 treatment arms based on baseline renal function.

ARM A (CREATININE CLEARANCE [CRCL] >= 50): Patients receive methotrexate intravenously (IV)
over 2-3 minutes, vinblastine IV, doxorubicin hydrochloride IV, and cisplatin IV over 4 hours
on day 1. Treatment repeats every 14 days for 4 courses in the absence of disease progression
or unacceptable toxicity. Patients without metastatic disease undergo nephroureterectomy and
lymph node dissection 21-60 days after completion of chemotherapy.

ARM B (30 =< CRCL < 50): Patients receive gemcitabine hydrochloride IV over 30-60 minutes on
days 1 and 8 and carboplatin IV over 30-60 minutes on day 1. Treatment repeats every 21 days
for 4 courses in the absence of disease progression or unacceptable toxicity. Patients
without metastatic disease undergo nephroureterectomy and lymph node dissection 21-60 days
after completion of chemotherapy.

After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.

Overal Status Start Date Phase Study Type
Recruiting Start Date: April 2015 Phase 2 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: pCR rates

Primary Outcome 1 - Time Frame: Up to 5 years

Condition:

  • Localized Urothelial Carcinoma of the Renal Pelvis and Ureter
  • Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter
  • Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

Eligibility

Criteria:
Inclusion Criteria:

- Patients must have high grade upper tract urothelial carcinoma proven by one of the
following:

- Biopsy;

- Urinary cytology with a 3-dimensional upper urinary tract mass on cross-sectional
imaging; or

- Urinary cytology and a mass visualized during upper urinary tract endoscopy

- Patients must have a creatinine clearance >= 30 ml/min as determined by
Cockcroft-Gault calculation or 24-hour urine creatinine clearance measurement within
28 days of registration to be eligible for the study

- Patients must have Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Patients must have no evidence of metastatic disease or clinically enlarged lymph
nodes on computed tomography (CT) or magnetic resonance imaging (MRI) of the abdomen
and pelvis and CT chest obtained within 28 days of registration (a negative biopsy is
required for lymph nodes > 1 cm in size to confirm lack of involvement); patients with
lymph nodes > 1 cm in whom a biopsy is deemed not feasible are not eligible; patients
with elevated alkaline phosphatase or suspicious bone pain should also undergo
baseline bone scans to evaluate for bone metastasis

- Patients with any component of small cell carcinoma are not eligible; other variant
histologies are permitted provided the predominant (>= 50%) subtype is urothelial
carcinoma

- Patients must not have peripheral neuropathy > grade 2

- Patients must not have a history of allergy or hypersensitivity to methotrexate,
vinblastine, doxorubicin (doxorubicin hydrochloride), cisplatin, gemcitabine
(gemcitabine hydrochloride), carboplatin or filgrastim or pegfilgrastim

- Patients must have a left ventricular ejection fraction (LVEF) >= 50% by (either
multigated acquisition [MUGA] or 2-dimensional [2-D] echocardiogram) within 28 days of
registration

- Absolute neutrophil count (ANC) >= 1500/mm^3

- Platelets >= 100,000/mm^3

- Hemoglobin (HgB) >= 9

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
< 2 X institutional upper limit of normal (ULN)

- Bilirubin within institutional normal limits (or < 2.5 X the ULN for patients with
Gilbert's disease)

- Patients with concomitant primaries of the bladder/urethra are allowed, as long as
these sites are surgically resected and non-invasive cancers (< cT1N0)

- Patients must not have another active second malignancy other than non-melanoma skin
cancers and biochemical relapsed prostate cancer; patients that have completed all
necessary therapy and are considered to be at less than 30% risk of relapse are not
considered to have an active second malignancy and are eligible for enrollment

- For patients who have creatinine clearance that meets >= 50 ml/min they must not have
received prior systemic doxorubicin

- Patients with uncontrolled illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, myocardial infarction in last 3
months, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social
situations that would limit compliance with study requirements are not eligible

- Patients who are known to have human immunodeficiency virus (HIV) or are on
combination antiretroviral therapy are ineligible

- Patients must have no prior radiation therapy to >= 25% of the bone marrow for other
diseases or prior systemic anthracycline therapy; prior intravesical anthracycline
therapy for non-muscle invasive urothelial carcinoma of the bladder is permitted

- Patients may have a history of resectable urothelial cancer (including neoadjuvant
chemotherapy) as long as patients meet one of the following:

- pT0, Tis, or T1N0 and have no evidence of disease (NED) for more than 2 years
from surgery or chemotherapy;

- pT2-3aN0 and NED for more than 3 years from surgery or chemotherapy; or

- > pT3b, or N+ and NED for more than 5 years from surgery or chemotherapy

- Women must not be pregnant or breast-feeding; all females of childbearing potential
must have a blood test or urine study within 2 weeks prior to registration to rule out
pregnancy; a female of childbearing potential is any woman, regardless of sexual
orientation or whether they have undergone tubal ligation, who meets the following
criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not
been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses
at any time in the preceding 24 consecutive months)

- Women of childbearing potential and sexually active males must use an accepted and
effective method of contraception or to abstain from sexual intercourse for the
duration of their participation in the study
Show More

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Vitaly Margulis

Role: Principal Investigator

Affiliation: ECOG-ACRIN Cancer Research Group

Locations

Facility Status Contact
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United States
Recruiting Guru P. Sonpavde
205-934-0309
University of Colorado Cancer Center - Anschutz Cancer Pavilion
Aurora, Colorado 80045
United States
Recruiting Elizabeth R. Kessler
720-848-0650
Memorial Hospital Colorado Springs
Colorado Springs, Colorado 80909
United States
Recruiting Elizabeth R. Kessler
720-848-0650
Poudre Valley Hospital
Fort Collins, Colorado 80524
United States
Recruiting Elizabeth R. Kessler
720-848-0650
Saint Francis Hospital and Medical Center
Hartford, Connecticut 06105
United States
Recruiting Christopher M. Reynolds
734-712-4673
Beebe Medical Center
Lewes, Delaware 19958
United States
Recruiting Gregory A. Masters
302-733-6227
Christiana Gynecologic Oncology LLC
Newark, Delaware 19713
United States
Recruiting Gregory A. Masters
302-733-6227
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware 19713
United States
Recruiting Gregory A. Masters
302-733-6227
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Recruiting Gregory A. Masters
302-733-6227
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
Recruiting Gregory A. Masters
302-733-6227
Regional Hematology and Oncology PA
Newark, Delaware 19713
United States
Recruiting Gregory A. Masters
302-733-6227
Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
United States
Recruiting Gregory A. Masters
302-733-6227
Beebe Health Campus
Rehoboth Beach, Delaware 19971
United States
Recruiting Gregory A. Masters
302-733-6227
Nanticoke Memorial Hospital
Seaford, Delaware 19973
United States
Recruiting Gregory A. Masters
302-733-6227
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware 19801
United States
Recruiting Gregory A. Masters
302-733-6227
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405
United States
Recruiting Howard A. Zaren
800-622-6877
Low Country Cancer Care Associates PC
Savannah, Georgia 31405
United States
Recruiting Howard A. Zaren
800-622-6877
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Recruiting Christopher M. Reynolds
734-712-4673
Saint Joseph Medical Center
Bloomington, Illinois 61701
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Carle on Vermilion
Danville, Illinois 61832
United States
Recruiting Vamsi K. Vasireddy
800-446-5532
Cancer Care Center of Decatur
Decatur, Illinois 62526
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Recruiting Vamsi K. Vasireddy
800-446-5532
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare Galesburg
Galesburg, Illinois 61401
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Recruiting Vamsi K. Vasireddy
800-446-5532
Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
United States
Recruiting Jay W. Carlson
800-821-7532
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Radiation Oncology of Northern Illinois
Ottawa, Illinois 61350
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Pekin Cancer Treatment Center
Pekin, Illinois 61554
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Methodist Medical Center of Illinois
Peoria, Illinois 61603
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
Peoria, Illinois 61615-7827
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
OSF Saint Francis Medical Center
Peoria, Illinois 61637
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Valley Radiation Oncology
Peru, Illinois 61354
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Central Illinois Hematology Oncology Center
Springfield, Illinois 62702
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Springfield Clinic
Springfield, Illinois 62703
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Memorial Medical Center
Springfield, Illinois 62781
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Cancer Care Specialists of Illinois-Swansea
Swansea, Illinois 62226
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Carle Cancer Center
Urbana, Illinois 61801
United States
Recruiting Vamsi K. Vasireddy
800-446-5532
The Carle Foundation Hospital
Urbana, Illinois 61801
United States
Recruiting Vamsi K. Vasireddy
800-446-5532
Franciscan Saint Anthony Health-Michigan City
Michigan City, Indiana 46360
United States
Recruiting Vamsi K. Vasireddy
800-446-5532
Woodland Cancer Care Center
Michigan City, Indiana 46360
United States
Recruiting Vamsi K. Vasireddy
800-446-5532
Reid Hospital and Health Care Services
Richmond, Indiana 47374
United States
Recruiting Howard M. Gross
937-775-1350
Oncology Hematology Care Inc-Crestview
Crestview Hills, Kentucky 41017
United States
Recruiting Howard M. Gross
937-775-1350
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
United States
Recruiting Marc R. Matrana
888-562-4763
Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106-0995
United States
Recruiting Christopher M. Reynolds
734-712-4673
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
United States
Recruiting Ajjai S. Alva
800-865-1125
Oakwood Hospital and Medical Center
Dearborn, Michigan 48124
United States
Recruiting Christopher M. Reynolds
734-712-4673
Saint John Hospital and Medical Center
Detroit, Michigan 48236
United States
Recruiting Christopher M. Reynolds
734-712-4673
Hurley Medical Center
Flint, Michigan 48502
United States
Recruiting Christopher M. Reynolds
734-712-4673
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Recruiting Christopher M. Reynolds
734-712-4673
Allegiance Health
Jackson, Michigan 49201
United States
Recruiting Christopher M. Reynolds
734-712-4673
Sparrow Hospital
Lansing, Michigan 48912
United States
Recruiting Christopher M. Reynolds
734-712-4673
Saint Mary Mercy Hospital
Livonia, Michigan 48154
United States
Recruiting Christopher M. Reynolds
734-712-4673
Saint Joseph Mercy Oakland
Pontiac, Michigan 48341
United States
Recruiting Christopher M. Reynolds
734-712-4673
Saint Joseph Mercy Port Huron
Port Huron, Michigan 48060
United States
Recruiting Christopher M. Reynolds
734-712-4673
Saint Mary's of Michigan
Saginaw, Michigan 48601
United States
Recruiting Christopher M. Reynolds
734-712-4673
Saint John Macomb-Oakland Hospital
Warren, Michigan 48093
United States
Recruiting Christopher M. Reynolds
734-712-4673
Central Care Cancer Center-Carrie J Babb Cancer Center
Bolivar, Missouri 65613
United States
Recruiting Jay W. Carlson
800-821-7532
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri 63628
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
CoxHealth Cancer Center
Branson, Missouri 65616
United States
Recruiting Jay W. Carlson
800-821-7532
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Southeast Cancer Center
Cape Girardeau, Missouri 63703
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Capital Region Medical Center-Goldschmidt Cancer Center
Jefferson City, Missouri 65109
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Freeman Health System
Joplin, Missouri 64804
United States
Recruiting Jay W. Carlson
800-821-7532
Mercy Hospital-Joplin
Joplin, Missouri 64804
United States
Recruiting Jay W. Carlson
800-821-7532
Phelps County Regional Medical Center
Rolla, Missouri 65401
United States
Recruiting Jay W. Carlson
800-821-7532
Saint John's Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
United States
Recruiting Jay W. Carlson
800-821-7532
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri 63109
United States
Recruiting Jay W. Carlson
800-821-7532
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
United States
Recruiting Jay W. Carlson
800-821-7532
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Mercy Hospital Springfield
Springfield, Missouri 65804
United States
Recruiting Jay W. Carlson
800-821-7532
CoxHealth South Hospital
Springfield, Missouri 65807
United States
Recruiting Jay W. Carlson
800-821-7532
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri 63127
United States
Recruiting James L. Wade
217-876-4740
kcheek@dmhhs.org
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Recruiting Howard M. Gross
937-775-1350
Oncology Hematology Care Inc-Eden Park
Cincinnati, Ohio 45202
United States
Recruiting Howard M. Gross
937-775-1350
Oncology Hematology Care Inc-Mercy West
Cincinnati, Ohio 45211
United States
Recruiting Howard M. Gross
937-775-1350
Oncology Hematology Care Inc - Anderson
Cincinnati, Ohio 45230
United States
Recruiting Howard M. Gross
937-775-1350
Oncology Hematology Care Inc - Kenwood
Cincinnati, Ohio 45236
United States
Recruiting Howard M. Gross
937-775-1350
Oncology Hematology Care Inc-Blue Ash
Cincinnati, Ohio 45242
United States
Recruiting Howard M. Gross
937-775-1350
Good Samaritan Hospital - Dayton
Dayton, Ohio 45406
United States
Recruiting Howard M. Gross
937-775-1350
Miami Valley Hospital
Dayton, Ohio 45409
United States
Recruiting Howard M. Gross
937-775-1350
Samaritan North Health Center
Dayton, Ohio 45415
United States
Recruiting Howard M. Gross
937-775-1350
Oncology Hematology Care Inc-Healthplex
Fairfield, Ohio 45014
United States
Recruiting Howard M. Gross
937-775-1350
Blanchard Valley Hospital
Findlay, Ohio 45840
United States
Recruiting Howard M. Gross
937-775-1350
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Recruiting Howard M. Gross
937-775-1350
Wayne Hospital
Greenville, Ohio 45331
United States
Recruiting Howard M. Gross
937-775-1350
Kettering Medical Center
Kettering, Ohio 45429
United States
Recruiting Howard M. Gross
937-775-1350
Springfield Regional Cancer Center
Springfield, Ohio 45504
United States
Recruiting Howard M. Gross
937-775-1350
Springfield Regional Medical Center
Springfield, Ohio 45505
United States
Recruiting Howard M. Gross
937-775-1350
Flower Hospital
Sylvania, Ohio 43560
United States
Recruiting Jeffrey H. Muler
419-824-1842
Upper Valley Medical Center
Troy, Ohio 45373
United States
Recruiting Howard M. Gross
937-775-1350
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Recruiting Kelly L. Stratton
405-271-4272
julie-traylor@ouhsc.edu
Tulsa Cancer Institute
Tulsa, Oklahoma 74146
United States
Recruiting Kelly L. Stratton
405-271-4272
julie-traylor@ouhsc.edu
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
United States
Recruiting Gregory A. Masters
302-733-6227
Geisinger Medical Center
Danville, Pennsylvania 17822
United States
Recruiting Joseph J. Vadakara
570-271-5251
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania 18201
United States
Recruiting Joseph J. Vadakara
570-271-5251
Geisinger Medical Oncology at Evangelical Community Hospital
Lewisburg, Pennsylvania 17837
United States
Recruiting Joseph J. Vadakara
570-271-5251
Lewistown Hospital
Lewistown, Pennsylvania 17044
United States
Recruiting Joseph J. Vadakara
570-271-5251
ECOG-ACRIN Cancer Research Group
Philadelphia, Pennsylvania 19103
United States
Recruiting Vitaly Margulis
214-648-0567
vitaly.margulis@utsouthwestern.edu
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
Recruiting Jean H. Hoffman-Censits
215-955-6084
Geisinger Medical Oncology-Pottsville
Pottsville, Pennsylvania 17901
United States
Recruiting Joseph J. Vadakara
570-271-5251
Geisinger Medical Group
State College, Pennsylvania 16801
United States
Recruiting Joseph J. Vadakara
570-271-5251
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
United States
Recruiting Joseph J. Vadakara
570-271-5251
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Recruiting Theodore S. Gourdin
843-792-9321
Vanderbilt-Ingram Cancer Center Cool Springs
Franklin, Tennessee 37067
United States
Recruiting Peter E. Clark
800-811-8480
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee 37204
United States
Recruiting Peter E. Clark
800-811-8480
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States
Recruiting Peter E. Clark
800-811-8480
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
Recruiting Vitaly Margulis
214-590-5582
Aurora Cancer Care-Burlington
Burlington, Wisconsin 53105
United States
Recruiting Rubina Qamar
888-709-2080
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
United States
Recruiting Rubina Qamar
888-709-2080
Vince Lombardi Cancer Clinic-Marinette
Marinette, Wisconsin 54143
United States
Recruiting Rubina Qamar
888-709-2080
Aurora Advanced Healthcare Inc-Menomonee Falls
Menomonee Falls, Wisconsin 53051
United States
Recruiting Rubina Qamar
888-709-2080
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
United States
Recruiting Rubina Qamar
888-709-2080
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
United States
Recruiting Rubina Qamar
888-709-2080
Aurora Cancer Care-Racine
Racine, Wisconsin 53406-5661
United States
Recruiting Rubina Qamar
888-709-2080
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United States
Recruiting Rubina Qamar
888-709-2080
Aurora Cancer Care-Waukesha
Waukesha, Wisconsin 53188
United States
Recruiting Rubina Qamar
888-709-2080