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BRIEF TITLE: Study of Atezolizumab (Anti−PD-L1 Antibody) as Monotherapy and in Combination With Platinum-Based Chemotherapy in Patients With Untreated Locally Advanced or Metastatic Urothelial Carcinoma

A Phase III, Multicenter, Randomized, Placebo-Controlled Study of Atezolizumab (Anti−PD-L1 Antibody) as Monotherapy and in Combination With Platinum-Based Chemotherapy in Patients With Untreated Locally Advanced or Metastatic Urothelial Carcinoma


  • Org Study ID: WO30070
  • Secondary ID: 2016-000250-35
  • NCT ID: NCT02807636
  • NCT Alias:
  • Sponsor: Hoffmann-La Roche - Industry
  • Source: Hoffmann-La Roche

Brief Summary

A Phase III, randomised study of atezolizumab alone and in combination with chemotherapy versus chemotherapy alone in participants with untreated advanced urothelial cancer.

Overal Status Start Date Phase Study Type
Recruiting June 30, 2016 Phase 3 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: Progression-Free Survival (PFS) Assessed by Investigator Using Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 in Participants Treated with Atezolizumab Combination Therapy Compared With Placebo Arm

Primary Outcome 1 - Time Frame: Baseline up to disease progression, death, or loss of follow-up, whichever occurs first (assessed at baseline, every 9 weeks for 54 weeks and every 12 weeks thereafter up to 44 months)

Primary Outcome 2 - Measure: Overall Survival (OS)

Primary Outcome 2 - Time Frame: Baseline until death due to any cause (up to 44 months)

Primary Outcome 3 - Measure: Percentage of Participants with Adverse Events (AEs) Assessed Using National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v4.0

Primary Outcome 3 - Time Frame: Baseline up to 44 months

Condition:

  • Urothelial Carcinoma

Eligibility

Criteria:
Inclusion Criteria

- Considered to be eligible to receive platinum-based chemotherapy, in the
investigator's judgment

- Eastern Cooperative Oncology Group (ECOG) performance status of less than or equal to
(

- Histologically documented, locally advanced (T4b, any N; or any T, N2-3) or metastatic
urothelial carcinoma (mUC) (M1, Stage IV) (also termed transitional cell carcinoma
[TCC] or urothelial cell carcinoma [UCC] of the urinary tract; including renal pelvis,
ureters, urinary bladder, and urethra)

- Representative formalin-fixed paraffin-embedded (FFPE) tumor specimens in paraffin
blocks (blocks preferred) or at least 15 unstained slides, with an associated
pathology report, for central testing and determined to be evaluable for tumor PD-L1
expression prior to study enrollment; participants who have fewer than 15 unstained
slides available at baseline (but no less than [<] 10) may be eligible following
discussion with the Medical Monitor

- No prior chemotherapy for inoperable locally advanced or mUC

- For participants who received prior adjuvant/neoadjuvant chemotherapy or
chemo-radiation for urothelial carcinoma, a treatment-free interval more than (>) 12
months between the last treatment administration and the date of recurrence is
required in order to be considered treatment naive in the metastatic setting

- Prior local intravesical chemotherapy or immunotherapy is allowed if completed at
least 4 weeks prior to the initiation of study treatment

- Measurable disease, as defined by RECIST v1.1

- Adequate hematologic and end-organ function

- For women of childbearing potential: agreement to remain abstinent (refrain from
heterosexual intercourse) or use contraceptive methods that result in a failure rate
of <1% per year during the treatment period and for at least 6 months after the last
dose of carboplatin, cisplatin, or gemcitabine or for 5 months after the last dose of
atezolizumab

- For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use
contraceptive measures and agreement to refrain from donating sperm

Exclusion Criteria:

- Any approved anti-cancer therapy, including chemotherapy or hormonal therapy, within 3
weeks prior to initiation of study treatment

- Treatment with any other investigational agent or participation in another clinical
study with therapeutic intent within 28 days prior to enrolment

- Active or untreated CNS metastases as determined by computed tomography (CT) or
magnetic resonance imaging evaluation during screening and prior radiographic
assessments

- Participants with treated asymptomatic central nervous system (CNS) metastases are
eligible, provided they meet all of the following criteria: * Evaluable or measurable
disease outside the CNS * No metastases to midbrain, pons, medulla, or within 10 mm of
the optic apparatus (optic nerves and chiasm) * No history of intracranial or spinal
cord hemorrhage * No ongoing requirement for corticosteroid as therapy for CNS
disease; anti-convulsants at a stable dose are allowed * No evidence of significant
vasogenic edema * No stereotactic radiation, whole-brain radiation or neurosurgical
resection within 4 weeks prior to Cycle 1, Day 1 * Radiographic demonstration of
interim stability (i.e., no progression) between the completion of CNS-directed
therapy and the screening radiographic study * Screening CNS radiographic study >/=4
weeks since completion of radiotherapy or surgical resection and >/=2 weeks since
discontinuation of corticosteroids

- Prior treatment with CD137 agonists, anti-CTLA-4, anti-programmed death-1 (PD-1), or
anti-PD-L1 therapeutic antibody or pathway-targeting agents

- Treatment with systemic corticosteroids or other systemic immunosuppressive
medications (including but not limited to prednisone, dexamethasone, cyclophosphamide,
azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [TNF] agents)
within 2 weeks prior to Cycle 1, Day 1 or anticipated requirement for systemic
immunosuppressive medications during the study

- Leptomeningeal disease

- Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent
drainage procedures (once monthly or more frequently)

- Uncontrolled tumour-related pain or hypercalcemia

- Significant cardiovascular disease including known left ventricular ejection fraction
(LVEF) <40%

- Severe infections within 4 weeks before randomization or therapeutic oral or IV
antibiotics within 2 weeks before randomization

- Major surgical procedure within 4 weeks prior to randomization or anticipation of need
for a major surgical procedure during the course of the study other than for diagnosis

- Malignancies other than urothelial carcinoma within 5 years prior to Cycle 1, Day 1

- Life expectancy of <12 weeks

- Pregnant or lactating, or intending to become pregnant during the study

- Serum albumin <25 gram per liter (g/L)

- History of severe allergic, anaphylactic, or other hypersensitivity reactions to
chimeric or humanized antibodies or fusion proteins

- Known hypersensitivity or allergy to biopharmaceuticals produced in Chinese hamster
ovary cells or any component of the atezolizumab formulation

- History of autoimmune disease

- Participants with prior allogeneic stem cell or solid organ transplantation

- History of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced
pneumonitis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic
organizing pneumonia), or evidence of active pneumonitis on screening chest CT scan

- Positive test for human immunodeficiency virus (HIV)

- Active hepatitis B or hepatitis C

- Active tuberculosis

- Administration of a live, attenuated vaccine within 4 weeks before Cycle 1, Day 1
Show More

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Clinical Trials

Role: Study Director

Affiliation: Hoffmann-La Roche

Overall Contact

Name: Reference Study ID Number: WO30070 www.roche.com/about_roche/roche_worldwide.htm

Phone: 888-662-6728 (U.S. and Canada)

Email: global.rochegenentechtrials@roche.com

Locations

Facility Status Contact
Mayo Clinic Arizona
Scottsdale, Arizona 85025
United States
Withdrawn
Highlands Oncology Group
Fayetteville, Arkansas 72703
United States
Recruiting
Comprehensive Blood & CA Ctr; Research
Bakersfield, California 93309
United States
Recruiting
Los Angeles Hematology Oncology Medical Group
Los Angeles, California 90017
United States
Recruiting
University of California Los Angeles (UCLA)
Los Angeles, California 90095
United States
Recruiting
Cancer Care Associates
Redondo Beach, California
United States
Recruiting
Coastal Integrative Cancer Care
San Luis Obispo, California 93401
United States
Recruiting
Central Coast Medical Oncology
Santa Maria, California 93454
United States
Recruiting
St. Mary's Hospital Regional Cancer Center
Grand Junction, Colorado 81501
United States
Recruiting
Danbury Hospital
Danbury, Connecticut 06810
United States
Recruiting
Yale School of Medicine
New Haven, Connecticut 06510
United States
Recruiting
Norwalk Hospital
Norwalk, Connecticut 06856
United States
Recruiting
Christiana Care Health Srvcs
Newark, Delaware 19713
United States
Recruiting
Florida Cancer Specialists; Department of Oncology
Fort Myers, Florida 33901-8101
United States
Recruiting
UF Health Cancer Center at Orlando Health
Orlando, Florida 32824
United States
Recruiting
Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building)
Saint Petersburg, Florida 33705
United States
Recruiting
Moffitt Cancer Center; GME Office
Tampa, Florida 33612
United States
Recruiting
The University of Chicago Biological Sciences; Dept. of Medicine, Section of Hematology/Oncology
Chicago, Illinois 60637
United States
Active, not recruiting
Parkview Research Center
Fort Wayne, Indiana 46845
United States
Recruiting
Cancer Center of Kansas
Wichita, Kansas 67214-3728
United States
Recruiting
Norton Cancer Institute
Louisville, Kentucky 40241
United States
Active, not recruiting
East Jefferson Hematology Oncology; Hematology Oncology-Yenni Pavillion
Metairie, Louisiana 70006
United States
Recruiting
Park Nicollet Clin-Cancer Ctr
Saint Louis Park, Minnesota 55426
United States
Recruiting
Jackson Oncology Associates, PLLC
Jackson, Mississippi 39202
United States
Recruiting
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89128
United States
Recruiting
MSK @Basking Ridge
Basking Ridge, New Jersey 07920
United States
Recruiting
Memorial Sloan Kettering Cancer Center; MSK Monmouth
Middletown, New Jersey 07748
United States
Recruiting
MSKCC @ Commack
Commack, New York 11725
United States
Recruiting
MSKCC @ West Harrison
Harrison, New York 10604
United States
Recruiting
Mount Sinai School of Medicine - Tisch Cancer Institute
New York, New York 10029
United States
Active, not recruiting
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Recruiting
MSKC @ Rockville
Rockville Centre, New York 11570
United States
Recruiting
University of North Carolina, Lineberger Cancer Ctr
Chapel Hill, North Carolina 27599
United States
Recruiting
Oregon Health & Science Uni
Portland, Oregon 97239
United States
Withdrawn
Fox Chase Cancer Center; Hematology/Oncology
Philadelphia, Pennsylvania 19111
United States
Terminated
Bon Secours - St. Francis Hospital
Greenville, South Carolina 29607
United States
Recruiting
Sarah Cannon Cancer Center
Germantown, Tennessee 38138
United States
Recruiting
Vanderbilt Ingram Cancer Clinic
Nashville, Tennessee 37232
United States
Recruiting
Macquarie University Hospital
Sydney, New South Wales 2109
Australia
Recruiting
Royal Brisbane and Women's Hospital
Herston, Queensland 4029
Australia
Recruiting
Lyell McEwin Hospital
Adelaide, South Australia 5112
Australia
Recruiting
Ashford Cancer Center Research
Kurralta Park, South Australia 5037
Australia
Recruiting
Box Hill Hospital
Box Hill, Victoria 3128
Australia
Recruiting
Cabrini Medical Centre; Oncology
Malvern, Victoria 3144
Australia
Recruiting
Sunshine Hospital; Oncology Research
St Albans, Victoria
Australia
Active, not recruiting
GHdC Site Notre Dame
Charleroi, 6000
Belgium
Recruiting
AZ Sint Lucas (Sint Lucas)
Gent, 9000
Belgium
Recruiting
UZ Leuven Gasthuisberg
Leuven, 3000
Belgium
Recruiting
Clinique Saint-Joseph
Liège, 4000
Belgium
Recruiting
University Clinical Centre of the Republic of Srpska
Banja Luka, 78000
Bosnia and Herzegovina
Recruiting
Clinic of Oncology, University Clinical Center Sarajevo
Sarajevo, 7100
Bosnia and Herzegovina
Active, not recruiting
Cetus Hospital Dia Oncologia
Belo Horizonte, MG 30150-270
Brazil
Active, not recruiting
Hospital Luxemburgo; Oncologia
Belo Horizonte, MG 31190-131
Brazil
Active, not recruiting
Clinicas Oncologicas Integradas - COI
Rio De Janeiro, RJ 22290-160
Brazil
Recruiting
Hospital de Caridade de Ijui; Oncologia
Ijui, RS 98700-000
Brazil
Active, not recruiting
Hospital das Clinicas - UFRGS
Porto Alegre, RS 90035-003
Brazil
Active, not recruiting
Hospital Sao Lucas - PUCRS
Porto Alegre, RS 90610-000
Brazil
Completed
Hospital Nossa Senhora da Conceicao
Porto Alegre, RS 91350-200
Brazil
Active, not recruiting
Clinica Viver
Santa Maria, RS 97015-373
Brazil
Recruiting
Clinica de Neoplasias Litoral
Itajai, SC 88301-220
Brazil
Recruiting
Hospital de Base de Sao Jose do Rio Preto
Sao Jose do Rio Preto, SP 15090-000
Brazil
Recruiting
Instituto do Cancer do Estado de Sao Paulo - ICESP
Sao Paulo, SP 01246-000
Brazil
Recruiting
Hospital A. C. Camargo; Oncologia
Sao Paulo, SP 01509-010
Brazil
Withdrawn
Hospital Sao Jose
São Paulo, SP CEP 01321-001
Brazil
Active, not recruiting
Tom Baker Cancer Centre-Calgary; Clinical Research Unit
Calgary, Alberta T2N 4N2
Canada
Active, not recruiting
Cross Cancer Institute
Edmonton, Alberta T6G 1Z2
Canada
Recruiting
BC Cancer Agency, CSI
Kelowna, British Columbia V1Y 5L3
Canada
Recruiting
Dr. Léon-Richard Oncology Centre
Moncton, New Brunswick E1C8X3
Canada
Recruiting
Juravinski Cancer Clinic; Clinical Trials Department
Hamilton, Ontario L8V 5C2
Canada
Active, not recruiting
Lakeridge Health Center; R. S. MacLaughlin Durham Regional Cancer Center
Oshawa, Ontario L1G 2B9
Canada
Recruiting
North York General Hospital
Toronto, Ontario M2J 1V1
Canada
Recruiting
Princess Margaret Cancer Center
Toronto, Ontario M5G 1Z6
Canada
Not yet recruiting
Centro del Cáncer UC
Santiago de Chile, 8330074
Chile
Withdrawn
Health & Care SPA
Santiago, 7500006
Chile
Recruiting
Fundacion Arturo Lopez Perez
Santiago, 7500921
Chile
Active, not recruiting
Hospital Clinico de La Universidad de Chile J.J.A.; Oncologia
Santiago, 8380456
Chile
Terminated
Centro Internacional de Estudios Clínicos (CIEC)
Santiago, 8420383
Chile
Recruiting
Clinica Alemana
Vitacura, 0
Chile
Recruiting
Anhui Provincial Hospital
Anhui, 230001
China
Withdrawn
CHINESE ACADEMY OF MEDICAL SCIENCE; CANCER INST. & HOSPITAL; Medical ward
Beijing, 100021
China
Withdrawn
Peking University First Hospital
Beijing, 100034
China
Withdrawn
Beijing Friendship Hospital
Beijing, 100050
China
Recruiting
Peking Union Medical College Hospital
Beijing, 100730
China
Recruiting
the First Hospital of Jilin University
Changchun, 130021
China
Withdrawn
Hu Nan Provincial Cancer Hospital
Changsha, 410006
China
Withdrawn
Chongqing Cancer Hospital
Chongqing, 400030
China
Recruiting
Sun Yat-sen Memorial Hospital
Guangzhou, 510000
China
Recruiting
Sun Yet-sen University Cancer Center
Guangzhou, 510060
China
Withdrawn
Zhejiang People's Hospital
Hangzhou City, 310014
China
Withdrawn
Zhejiang Cancer Hospital
Hangzhou, 310022
China
Withdrawn
Jiangsu Cancer Hospital
Nanjing, 210009
China
Recruiting
Jiangsu Province Hospital
Nanjing, 210036
China
Recruiting
Huashan Hospital Affiliated to Fudan University
Shanghai City, 200040
China
Withdrawn
Fudan University Shanghai Cancer Center
Shanghai, 200032
China
Recruiting
Zhongshan Hospital Fudan University
Shanghai, 200032
China
Recruiting
Huadong Hospital Affiliated to Fudan University
Shanghai, 200040
China
Recruiting
Shanghai First People's Hospital
Shanghai, 200080
China
Recruiting
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, 200092
China
Withdrawn
The 2nd Hospital of Tianjin Medical University
Tianjin, 201203
China
Recruiting
The First Affiliated Hospital of Xiamen University
Xiamen, 361003
China
Withdrawn
Masarykuv onkologicky ustav
Brno, 656 53
Czechia
Active, not recruiting
Fakultni nemocnice Olomouc; Onkologicka klinika
Olomouc, 779 00
Czechia
Active, not recruiting
Vseobecna fakultni nemocnice v Praze
Praha 2, 128 08
Czechia
Active, not recruiting
University Hospital Motol; Department of Urology
Praha 5, 15006
Czechia
Active, not recruiting
East Tallinn Central Hospital
Tallinn, 10138
Estonia
Recruiting
North Estonia Medical Centre Foundation; Oncology Center
Tallinn, 13419
Estonia
Active, not recruiting
Oulu University Hospital; Oncology
Oulu, 90029
Finland
Recruiting
Turku Uni Central Hospital; Oncology Clinics
Turku, 20520
Finland
Recruiting
Research institute for Clinical Medicine
Tbilisi, 0112
Georgia
Active, not recruiting
National Center of Urology
Tbilisi, 0144
Georgia
Not yet recruiting
Chemotherapy and Immunotherapy Clinic Medulla
Tbilisi, 0186
Georgia
Active, not recruiting
Alexandras General Hospital of Athens; Oncology Department
Athens, 115 28
Greece
Recruiting
University Hospital of Patras Medical Oncology
Patras, 265 04
Greece
Recruiting
Queen Mary Hospital; Dept. of Clinical Oncology
Hong Kong, 852
Hong Kong
Recruiting
Princess Margaret Hospital; Oncology
Hong Kong,
Hong Kong
Recruiting
Queen Elizabeth Hospital; Clinical Oncology
Hong Kong,
Hong Kong
Recruiting
The Chinese University of Hong Kong; Department of Clinical Oncology
N.t.,
Hong Kong
Recruiting
Rambam Health Care Campus; Oncology
Haifa, 3109601
Israel
Recruiting
Meir Medical Center; Oncology
Kfar-Saba, 4428164
Israel
Recruiting
Assaf Harofeh; Oncology
Zerifin, 6093000
Israel
Recruiting
Azienda Ospedaliera A. Cardarelli; Dip. Oncopneumoematologico
Napoli, Campania 80131
Italy
Active, not recruiting
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, Emilia-Romagna 47014
Italy
Recruiting
A.O. Universitaria Policlinico Di Modena; Oncologia
Modena, Emilia-Romagna 41100
Italy
Recruiting
Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche
Roma, Lazio 00161
Italy
Recruiting
Az. Osp. Uni Ria San Martino; Cliniche Uni Rie Convenzionate U.O. Oncologia Medical
Genova, Liguria 16132
Italy
Recruiting
ASST DI CREMONA; Dip. Medicina - S.C. Oncologia
Cremona, Lombardia 26100
Italy
Recruiting
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2
Milano, Lombardia 20133
Italy
Recruiting
Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia
Rozzano, Lombardia 20089
Italy
Recruiting
A.O CITTA' DELLA SALUTE E DELLA SCIENZA D. - Presidio San Lazzaro; Oncologia medica 2
Torino, Piemonte 10126
Italy
Recruiting
IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
San Giovanni Rotondo, Puglia 71013
Italy
Recruiting
Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia
Arezzo, Toscana 52100
Italy
Recruiting
Azienda Ospedaliera S. Maria - Terni; Oncologia
Terni, Umbria 05100
Italy
Active, not recruiting
IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima
Padova, Veneto 35128
Italy
Recruiting
Nagoya University Hospital
Aichi, 466-8560
Japan
Recruiting
Hirosaki University Hospital
Aomori, 036-8563
Japan
Recruiting
National Hospital Organization Shikoku Cancer Center
Ehime, 791-0280
Japan
Active, not recruiting
Gunma University Hospital
Gunma, 371-8511
Japan
Active, not recruiting
Hiroshima University Hospital
Hiroshima, 734-8551
Japan
Recruiting
National Hospital Organization Hokkaido Cancer Center
Hokkaido, 003-0804
Japan
Active, not recruiting
University of Tsukuba Hospital
Ibaraki, 305-8576
Japan
Active, not recruiting
Kanazawa University Hospital
Ishikawa, 920-8641
Japan
Recruiting
Kumamoto University Hospital
Kumamoto, 860-8556
Japan
Recruiting
Niigata University Medical & Dental Hospital
Niigata, 951-8520
Japan
Recruiting
Osaka City University Hospital
Osaka, 545-8586
Japan
Active, not recruiting
Kindai University Hospital
Osaka, 589-8511
Japan
Recruiting
Toranomon Hospital
Tokyo, 105-8470
Japan
Recruiting
The Cancer Institute Hospital, JFCR; Urology
Tokyo, 135-8550
Japan
Active, not recruiting
Keio University Hospital
Tokyo, 160-8582
Japan
Recruiting
Kyungpook National University Medical Center
Daegu, 41404
Korea, Republic of
Recruiting
Gachon University Gil Medical Center
Incheon, 21565
Korea, Republic of
Active, not recruiting
Korea University Anam Hospital
Seoul, 02841
Korea, Republic of
Active, not recruiting
Seoul National University Hospital
Seoul, 03080
Korea, Republic of
Active, not recruiting
Severance Hospital, Yonsei University Health System
Seoul, 03722
Korea, Republic of
Recruiting
Asan Medical Center
Seoul, 05505
Korea, Republic of
Recruiting
Samsung Medical Center
Seoul, 06351
Korea, Republic of
Recruiting
Hospital Kuala Lumpur; Jabatan Radioterapi dan Onkologi
Kuala Lumpur, 50586
Malaysia
Recruiting
University Malaya Medical Centre; Clinical Oncology Unit,
Kuala Lumpur, 59100
Malaysia
Recruiting
Subang Jaya Medical Centre
Selangor, 47500
Malaysia
Terminated
Health Pharma Professional Research
CD Mexico, Mexico CITY (federal District) 03810
Mexico
Recruiting
Medical Care & Research
Mérida, Yucatan 97070
Mexico
Terminated
IMSS Hospital General de Zona No. 48 S. Pedro Xalpa; Departamento de Urología
Ciudad De México DF, 02710
Mexico
Recruiting
Hospital Angeles; Oncology
Leon, 37150
Mexico
Withdrawn
Hospital San Jose; Centro de investigacion y transferencia en salud del Tec de Monterrey
Monterrey, N.L, 64710
Mexico
Active, not recruiting
Cancerología
Queretaro, 76090
Mexico
Recruiting
Clinica Sociedad Española de Beneficencia
Veracruz, 91700
Mexico
Terminated
Consultorio Médico
Zapopan, Jalisco, 45040
Mexico
Active, not recruiting
Martini Ziekenhuis; Dept of Internal Medicine
Groningen, 9728 NT
Netherlands
Recruiting
Hagaziekenhuis, locatie Leyweg
Nl -den Haag, 2504 LN
Netherlands
Recruiting
Zuyderland Medisch Centrum; Internal Diseases
Sittard-Geleen, 6162 BG
Netherlands
Recruiting
Isala Klinieken, Sophia
Zwolle, 8025 AB
Netherlands
Recruiting
Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej
Bialystok, 15-027
Poland
Recruiting
Centrum Onkologii w Bydgoszczy; Oddzial Kliniczny Onkologii
Bydgoszcz, 85-796
Poland
Terminated
Szpital im. Stanislawa Leszczynskiego, Oddzial Onkologii
Katowice, 40-074
Poland
Withdrawn
Przychodnia Lekarska KOMED
Konin, 62-500
Poland
Recruiting
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii
Krakow, 31-531
Poland
Recruiting
Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii; Oddz.Hematologii Pododz.Chemioterapii
Lodz, 93-513
Poland
Terminated
Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii; Oddz.Hematologii Pododz.Chemioterapii
Lodz, 93-513
Poland
Recruiting
Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu
Poznan, 60-569
Poland
Active, not recruiting
NU-MED Centrum Diagnostyki i Terapii Onkologicznej
Tomaszów Mazowiecki, 97-200
Poland
Recruiting
Centralny Szpital Kliniczny MSWiA; Klinika Urologii i Urologii Onkologicznej
Warsaw, 02-507
Poland
Withdrawn
Szpital Sw. Elzbiety - Mokotowskie Centrum Medyczne Sp. z o.o.
Warszawa, 02-616
Poland
Recruiting
Centrum Med. Ostrobramska NZOZ Magodent
Warszawa, 04-125
Poland
Withdrawn
Uniwersytecki Szpital Kliniczny im. Jana Miklulicza-Radeckiego we Wrocławiu; Departament Of Urology
Wroclaw, 50-556
Poland
Recruiting
Centrum Medyczne Salve Medica
Łódź, 91-211
Poland
Terminated
Hospital de Santa Maria; Servico de Oncologia Medica
Lisboa, 1649-035
Portugal
Recruiting
IPO do Porto; Servico de Oncologia Medica
Porto, 4200-072
Portugal
Recruiting
Spitalul Judetean de Urgenta Dr Constantin Opris
Baia Mare, 430031
Romania
Active, not recruiting
Institute Of Oncology Bucharest; Medical Oncology
Bucharest, 022338
Romania
Recruiting
Institut Oncologic Ion Chiricuta; Departament Radioterapie
Cluj-napoca, 400015
Romania
Withdrawn
Oncology Center Sf. Nectarie
Craiova, 200347
Romania
Active, not recruiting
Euroclinic Center of Oncology SRL
Iasi, 700106
Romania
Terminated
ALTAI REGIONAL ONCOLOGICAL CENTER; "Nadezhda" Clinic
Barnaul, Altaj 656049
Russian Federation
Active, not recruiting
SBEI HPE "The First St.Petersburg State Medical University n.a. acad. I.P.Pavlova"of MoH of RF
Sankt-peterburg, Leningrad 197022
Russian Federation
Recruiting
Sverdlovsk Regional Clinical Hospital 1
Ekaterinburg, 620102
Russian Federation
Recruiting
Ivanovo Regional Oncology Dispensary
Ivanovo, 153040
Russian Federation
Recruiting
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky; Chemotherapy
Krasnoyarsk, 660133
Russian Federation
Recruiting
Blokhin Cancer Research Center; Urological Dept
Moscow, 115478
Russian Federation
Active, not recruiting
Russian Scientific Center of Roentgenoradiology
Moscow, 117997
Russian Federation
Recruiting
P.A. Herzen Oncological Inst. ; Oncology
Moscow, 125284
Russian Federation
Recruiting
Privolzhsk Regional Medical Center
Nizhny Novgorod, 603001
Russian Federation
Recruiting
Scientific Research Oncology Institute named after N.N. Petrov; Oncology
St. Petersburg, 197758
Russian Federation
Recruiting
SBEI of HPE "Bashkir State Medical University" of MoH RF
Ufa, 450000
Russian Federation
Active, not recruiting
Clinic for Urology, Clinical Center of Serbia; Clinic for Urology
Belgrade, 11000
Serbia
Recruiting
Clinical Center of Serbia; Clinic of Urology
Belgrade, 11000
Serbia
Active, not recruiting
Clinical Centre Nis, Clinic for Oncology
Nis, 18000
Serbia
Active, not recruiting
Oncology Institute of Vojvodina
Sremska Kamenica, 21204
Serbia
Recruiting
National University Hospital; National University Cancer Institute, Singapore (NCIS)
Singapore, 119228
Singapore
Recruiting
National Cancer Centre; Medical Oncology
Singapore, 169610
Singapore
Recruiting
Oncocare Cancer Centre; Gleneagles Medical Centre
Singapore,
Singapore
Recruiting
Institute of Oncology Ljubljana
Ljubljana, 1000
Slovenia
Active, not recruiting
GVI Oncology Outeniqua Unit; GVI Oncology Outeniqua Unit
George, 6530
South Africa
Not yet recruiting
Wits Donald Gordon Clinical Trial Site
Johannesburg, 2041
South Africa
Withdrawn
Cancercare
Port Elizabeth, 6045
South Africa
Active, not recruiting
Wilgers Oncology Centre
Pretoria, 0001
South Africa
Recruiting
Steve Biko Academic Hospital; Oncology
Pretoria, 0002
South Africa
Recruiting
Sandton Oncology Medical Group
Sandton, 2196
South Africa
Recruiting
Hospital General Universitario de Elche; Servicio de Oncologia
Elche, Alicante 03203
Spain
Recruiting
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
Badalona, Barcelona 08916
Spain
Recruiting
Complejo Hospitalario de Althaia; Servicio de Oncologia
Manresa, Barcelona 08243
Spain
Recruiting
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
Sabadell, Barcelona 08208
Spain
Recruiting
Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
Santander, Cantabria 39008
Spain
Recruiting
Hospital Universitario Reina Sofia; Servicio de Oncologia
Córdoba, Cordoba 14004
Spain
Recruiting
Hospital Universitario Son Espases
Palma De Mallorca, Islas Baleares 07014
Spain
Recruiting
Clinica Universitaria de Navarra; Servicio de Oncologia
Pamplona, Navarra 31008
Spain
Active, not recruiting
Hospital Alvaro Cunqueiro
Vigo, Pontevedra 36312
Spain
Recruiting
Hospital de Basurto; Servicio de Oncologia
Bilbao, Vizcaya 48013
Spain
Recruiting
Complejo Hospitalario Universitario de Albacete; Servicio de Oncologia
Albacete, 02006
Spain
Recruiting
Hospital Univ Vall d'Hebron; Servicio de Oncologia
Barcelona, 08035
Spain
Recruiting
Hospital Clinic de Barcelona. Unidad de Nuevas Terapias;Oncology Department
Barcelona, 08036
Spain
Recruiting
Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
Barcelona, 08041
Spain
Active, not recruiting
Institutio Catalan De Oncologia
Barcelona, 08908
Spain
Recruiting
Complejo Asistencial Universitario De Burgos; Servicio de Oncologia
Burgos, 09006
Spain
Recruiting
Hospital San Pedro De Alcantara; Servicio de Oncologia
Caceres, 10003
Spain
Recruiting
Hospital Provincial de Castellon; Servicio de Oncologia
Castellon, 12002
Spain
Active, not recruiting
Hospital Universitario Virgen de las Nieves; Servicio de Oncologia
Granada, 18014
Spain
Recruiting
Hospital Juan Ramon Jimenez;Servicio de Oncologia
Huelva, 21005
Spain
Recruiting
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Jaen, 23007
Spain
Recruiting
Complejo Asistencial Universitario de Leon; Servicio de Oncologia
Leon, 24071
Spain
Recruiting
Hospital Universitario Lucus Augusti
Lugo, 27003
Spain
Recruiting
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
Madrid, 28007
Spain
Recruiting
MD Anderson Cancer Center
Madrid, 28033
Spain
Recruiting
Hospital Ramon y Cajal; Servicio de Oncologia
Madrid, 28034
Spain
Active, not recruiting
Hospital Universitario Clínico San Carlos; Servicio de Oncologia
Madrid, 28040
Spain
Recruiting
Hospital Universitario 12 de Octubre; Servicio de Oncologia
Madrid, 28041
Spain
Active, not recruiting
Hospital Universitario La Paz; Servicio de Oncologia
Madrid, 28046
Spain
Recruiting
Hospital Universitario Virgen del Rocio; Servicio de Oncologia
Sevilla, 41013
Spain
Recruiting
Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia
Toledo, 45004
Spain
Recruiting
Hospital Clínico Universitario de Valencia; Servicio de Oncología
Valencia, 46010
Spain
Terminated
Hospital Universitario la Fe; Servicio de Oncologia
Valencia, 46026
Spain
Recruiting
Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
Zaragoza, 50009
Spain
Recruiting
Hospital Universitario Miguel Servet; Servicio de Oncologia Medica
Zaragoza, 50009
Spain
Recruiting
Chang Gung Medical Foundation - Kaohsiung; Oncology
Kaohisung,
Taiwan
Recruiting
China Medical University Hospital; Urology
Taichung, 40447
Taiwan
Recruiting
Taichung Veterans General Hospital; Division of Urology
Taichung, 407
Taiwan
Recruiting
National Cheng Kung Uni Hospital; Dept of Hematology and Oncology
Tainan, 704
Taiwan
Recruiting
National Taiwan Uni Hospital; Dept of Oncology
Taipei, 100
Taiwan
Active, not recruiting
Chang Gung Medical Foundation-Linkou, Urinary Oncology
Taoyuan, 333
Taiwan
Recruiting
Vajira Hospital
Bangkok, 10300
Thailand
Recruiting
Chulalongkorn Hospital; Medical Oncology
Bangkok, 10330
Thailand
Active, not recruiting
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc
Bangkok, 10400
Thailand
Active, not recruiting
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology
Bangkok, 10700
Thailand
Recruiting
Maharaj Nakorn Chiang Mai Hosp; Oncology Unit
Chiangmai, 50200
Thailand
Active, not recruiting
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology
Adana, 01250
Turkey
Recruiting
Yildirim Beyazit University Medical Faculty Ataturk Training and Research Hospital
Ankara, 06800
Turkey
Recruiting
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
Edirne, 22030
Turkey
Recruiting
Bezmi Alem Vakif University Medical School; Oncology
Istanbul, 34093
Turkey
Recruiting
Istanbul University Cerrahpasa Medical Faculty; Medikal Onkoloji Departmani
Istanbul, 34098
Turkey
Recruiting
Medeniyet University Goztepe Training and Research Hospital; Internal Diseases
Istanbul, 34730
Turkey
Recruiting
Medikal Park Izmir Hospital
Karşıyaka, 35575
Turkey
Recruiting
19 Mayis University Medical Faculty; Medical Oncology Department
Samsun, 55139
Turkey
Recruiting
Hacettepe Uni Medical Faculty Hospital; Oncology Dept
Sıhhiye, Ankara, 06100
Turkey
Active, not recruiting
Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval Department of Urology #4
Kharkiv, Kharkiv Governorate 61037
Ukraine
Recruiting
CI Dnipropetrovsk CMCH #4 MA of MOHU Ch of Oncology and MR
Dnipropetrovsk, 49102
Ukraine
Active, not recruiting
Zaporizhzhia Regional Clinic
Zaporizhzhia, 69600
Ukraine
Terminated
Addenbrookes Nhs Trust; Oncology Clinical Trials Unit
Cambridge, CB2 0QQ
United Kingdom
Withdrawn
Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN
United Kingdom
Active, not recruiting
University College London Hospitals NHS Foundation Trust - University College Hospital
London, NW1 2PG
United Kingdom
Recruiting
The Christie NHS Foundation Trust
Manchester, M20 4BX
United Kingdom
Recruiting
Nottingham University Hospitals NHS Trust
Nottingham, NG7 2UH
United Kingdom
Recruiting
The York Hospital
York, YO31 8HE
United Kingdom
Recruiting