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BRIEF TITLE: Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Subjects With Advanced Urothelial Cancer and Selected FGFR Gene Aberrations

A Phase 3 Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Subjects With Advanced Urothelial Cancer and Selected FGFR Gene Aberrations


  • Org Study ID: CR108401
  • Secondary ID: 2017-002932-18,42756493BLC3001
  • NCT ID: NCT03390504
  • NCT Alias:
  • Sponsor: Janssen Research & Development, LLC - Industry
  • Source: Janssen Research & Development, LLC

Brief Summary

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-PD-(L) 1 agent (cohort 1) or 1 prior treatment not containing an anti-PD-(L) 1 agent (cohort 2).

Detailed Description


A study of erdafitinib versus standard of care, consisting of chemotherapy (docetaxel or
vinflunine) or anti-PD-(L) 1 agent pembrolizumab, in participants with advanced urothelial
cancer and selected FGFR aberrations who have progressed on or after 1 or 2 prior treatments,
at least 1 of which includes an anti-PD-(L) 1 agent (cohort 1) or 1 prior treatment not
containing an anti-PD-(L) 1 agent (cohort 2). It will consist of screening, treatment phase
(from randomization until disease progression, intolerable toxicity, withdrawal of consent or
decision by investigator to discontinue treatment, post-treatment followup (from
end-of-treatment to participants death, withdraws consent, lost to follow-up, or end of
study, whichever comes first). Efficacy, pharmacokinetics, biomarkers, patient reported
outcomes, medical resource utilization and safety will be assessed.

Overal Status Start Date Phase Study Type
Recruiting March 23, 2018 Phase 3 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: Overall Survival (OS)

Primary Outcome 1 - Time Frame: Date of first randomization to the date of participant's death (approximately up to 3 years)

Condition:

  • Urothelial Cancer

Eligibility

Criteria:
Inclusion Criteria:

- Histologic demonstration of transitional cell carcinoma of the urothelium. Minor
components ( less than [<] 50 percent [%] overall) of variant histology such as
glandular or squamous differentiation, or evolution to more aggressive phenotypes such
as sarcomatoid or micropapillary change are acceptable

- Metastatic or surgically unresectable urothelial cancer

- Documented progression of disease, defined as any progression that requires a change
in treatment, prior to randomization

- Cohort 1: Prior treatment with an anti-PD-(L) 1 agent as monotherapy or as combination
therapy; no more than 2 prior lines of systemic treatment. Cohort 2: No prior
treatment with an anti-PD-(L) 1 agent; only 1 line of prior systemic treatment.
Subjects who received neoadjuvant or adjuvant chemotherapy and showed disease
progression within 12 months of the last dose are considered to have received systemic
therapy in the metastatic setting.

- A woman of childbearing potential who is sexually active must have a negative
pregnancy test (beta human chorionic gonadotropin [beta hCG]) at Screening (urine or
serum)

- Participants must meet appropriate molecular eligibility criteria

- Eastern Cooperative Oncology Group (ECOG) performance status Grade 0, 1, or 2

- Adequate bone marrow, liver, and renal function

Exclusion Criteria:

- Treatment with any other investigational agent or participation in another clinical
study with therapeutic intent within 30 days prior to randomization

- Active malignancies (that is, requiring treatment change in the last 24 months). The
only allowed exceptions are: urothelial cancer, skin cancer treated within the last 24
months that is considered completely cured, localized prostate cancer with a gleason
score of 6 (treated within the last 24 months or untreated and under surveillance) and
localized prostate cancer with a gleason score of 3+4 that has been treated more than
6 months prior to full study screening and considered to have a very low risk of
recurrence.

- Symptomatic central nervous system metastases

- Received prior fibroblast growth factor receptor (FGFR) inhibitor treatment

- Known allergies, hypersensitivity, or intolerance to erdafitinib or its excipients

- Current central serous retinopathy (CSR) or retinal pigment epithelial detachment of
any grade.

- History of uncontrolled cardiovascular disease

- Impaired wound healing capacity defined as skin/decubitus ulcers, chronic leg ulcers,
known gastric ulcers, or unhealed incisions
Show More

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Janssen Research & Development, LLC Clinical Trials

Role: Study Director

Affiliation: Janssen Research & Development, LLC

Overall Contact

Name: Study Contact

Phone: 844-434-4210

Email: JNJ.CT@sylogent.com

Link: To learn how to participate in this trial please click here.

Locations

Facility Status Contact
Alaska Urological Institute dba Alaska Clinical Research Center
Anchorage, Alaska 99503
United States
Recruiting
University Of UA Cancer Center(UACC)/DH-SJHMC
Phoenix, Arizona 85004
United States
Withdrawn
University of California Irvine Medical Center - Chao Family Comprehensive Cancer Center
Orange, California 92868
United States
Withdrawn
University of Calif Davis Medical Center
Sacramento, California 95817
United States
Recruiting
St. Helena Hospital - Martin-O'Neil Cancer Center
Saint Helena, California 94574
United States
Recruiting
Kaiser Permanente Medical Center
Vallejo, California 95119
United States
Not yet recruiting
UCHealth Anschutz Cancer Pavilion
Aurora, Colorado 80045
United States
Withdrawn
MedStar Georgetown University Hospital
Washington, District of Columbia 20007
United States
Recruiting
University of Miami/Sylvester Cancer Center
Miami, Florida 33136
United States
Recruiting
Mid-Florida Hematology Oncology
Orange, Florida 32763
United States
Completed
Piedmont Cancer Institute
Atlanta, Georgia 30318-0922
United States
Completed
St. Luke's Meridian Medical Center
Meridian, Idaho 83642
United States
Withdrawn
Rush University
Chicago, Illinois 60612
United States
Recruiting
Edward Hines Jr V A Hospital
Hines, Illinois 60141
United States
Not yet recruiting
Norton Cancer Institute
Louisville, Kentucky 40202
United States
Recruiting
University of Michigan Health System
Ann Arbor, Michigan 48109-5000
United States
Completed
University of Nebraska Medical Center
Omaha, Nebraska 68198-0600
United States
Withdrawn
VA Sierra Nevada Health Care System
Reno, Nevada 89509
United States
Recruiting
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire 03756
United States
Recruiting
Montefiore Medical Center
Bronx, New York 10461
United States
Recruiting
Weill Cornell Medical College
New York, New York 10029
United States
Recruiting
Memorial Sloan-Kettering Cancer Center
New York, New York 10065
United States
Withdrawn
Levine Cancer Institute, Carolinas HealthCare System
Charlotte, North Carolina 28204
United States
Recruiting
Duke University
Durham, North Carolina 27701
United States
Withdrawn
W. G. 'Bill' Hefner VA Medical Center
Salisbury, North Carolina 28144
United States
Recruiting
Penn State Hershey Cancer Institute
Hershey, Pennsylvania 17033
United States
Withdrawn
University of Pittsburgh Medical Center (UPMC)
Pittsburgh, Pennsylvania 15232
United States
Withdrawn
University of Missouri
Columbia, South Carolina 65212-1000
United States
Withdrawn
The Center for Cancer and Blood Disorders
Fort Worth, Texas 76104
United States
Recruiting
MD Anderson Cancer Center
Houston, Texas 77030
United States
Recruiting
INOVA Dwiight &Martha Schar Cancer Institute
Fairfax, Virginia 22031
United States
Recruiting
Virginia Oncology Associates
Norfolk, Virginia 23502
United States
Not yet recruiting
VA Puget Sound Healthcare System
Seattle, Washington 98108
United States
Recruiting
Chris O'Brien Lifehouse
Camperdown, 2050
Australia
Recruiting
Peninsula & South Eastern Haematology and Oncology Group
Frankston, 3199
Australia
Recruiting
Royal Hobart Hospital
Hobart, 7000
Australia
Withdrawn
St George Hospital
Kogarah, 2217
Australia
Recruiting
Peter MacCallum Cancer Centre
Melbourne, 3000
Australia
Recruiting
Frankston Hospital
Melbourne, 3199
Australia
Recruiting
Fiona Stanley Hospital
Murdoch, 6150
Australia
Recruiting
LKH-Univ. Klinikum Graz
Graz, 8036
Austria
Recruiting
Ordensklinikum Linz GmbH Elisabethinen
Linz, 4020
Austria
Recruiting
LKH - Universitätsklinikum der PMU Salzburg
Salzburg, 5020
Austria
Recruiting
Medical University Vienna, MUV
Vienna, A-1090
Austria
Recruiting
OLV Ziekenhuis Aalst
Aalst, 9300
Belgium
Recruiting
ZNA Middelheim
Antwerpen, 2020
Belgium
Recruiting
Cliniques Universitaires Saint-Luc
Brussel, 1200
Belgium
Recruiting
Clinique Notre Dame de Grâce
Charleroi, 6000
Belgium
Recruiting
AZ Maria Middelares
Gent, 9000
Belgium
Recruiting
UZ Gent
Gent, 9000
Belgium
Recruiting
CHC-Cliniques Saint-Joseph
Liège, 4000
Belgium
Recruiting
Sint-Augustinus AZ
Wilrijk, 2610
Belgium
Recruiting
Chu Dinant Godinne UCL Namur
Yvoir, 5530
Belgium
Recruiting
Fundacao Pio Xii - Hospital De Cancer De Barretos
Barretos, 14784-400
Brazil
Recruiting
Associação Mário Penna\Núcleo de Ensino e Pesquisas
Belo Horizonte, 30380-472
Brazil
Recruiting
Hospital Erasto Gaertner
Curitiba, 81520-060
Brazil
Recruiting
Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás
Goiânia, 74605-070
Brazil
Not yet recruiting
Clínica de Neoplasias Litoral Ltda.
Itajai, 88301-220
Brazil
Recruiting
Upco - Hcpa
Porto Alegre, 90035-903
Brazil
Recruiting
INCA - Instituto Nacional Do Cancer
Rio de Janeiro, 20231-050
Brazil
Recruiting
Oncoclínicas
Rio de Janeiro, 22250-905
Brazil
Not yet recruiting
Fundacao Antonio Prudente
Sao Paulo, 01509900
Brazil
Recruiting
Ibcc - Instituto Brasileiro de Controle Do Cancer
Sao Paulo,
Brazil
Not yet recruiting
Hospital de Base de São José do Rio Preto
São José do Rio Preto, 15090-000
Brazil
Recruiting
Sociedade Beneficiante de Senhoras - Hospital Sirio Libanes
São Paulo, 01308901
Brazil
Recruiting
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, 04502-001
Brazil
Not yet recruiting
Hospital Israelita Albert Einstein
São Paulo, 05651-900
Brazil
Not yet recruiting
CEPHO - Faculdade de Medicina do ABC
São Paulo, 09060-650
Brazil
Recruiting
BC Cancer Agency - Southern Interior
Kelowna, British Columbia V1Y 5L3
Canada
Recruiting
Vancouver Cancer Centre
Vancouver, British Columbia V5Z 4E6
Canada
Recruiting
Cancercare Manitoba
Winnipeg, Manitoba R3E 0V9
Canada
Recruiting
Thunder Bay Regional Health Sciences Centre
Thunder Bay, Ontario P7B 6V4
Canada
Recruiting
Princess Margaret Hospital- UHN
Toronto, Ontario M5G 2M9
Canada
Recruiting
Saskatchewan Cancer Agency (SCA) - Allan Blair Cancer Centre
Regina, Saskatchewan S4T 7T1
Canada
Recruiting
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, 100021
China
Not yet recruiting
Peking University First Hospital
Beijing, 100034
China
Recruiting
Beijing Friendship Hospital
Beijing, 100050
China
Recruiting
Peking University Third Hospital
Beijing, 100191
China
Not yet recruiting
Beijing Hospital
BeiJing, 100730
China
Recruiting
Peking Union Medical College Hospital
Beijing, 100730
China
Not yet recruiting
Sichuan Provincial People's Hospital
Chengdu, 610000
China
Recruiting
Chongqing Medical University
Chongqing, 400030
China
Not yet recruiting
Sun Yat-Sen University Cancer Center
Guangzhou, 510060
China
Not yet recruiting
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Guangzhou, 510120
China
Recruiting
Guangzhou First Municipal People's Hospital
Guangzhou, 510180
China
Recruiting
Zhejiang Provincial People's Hospital
Hangzhou, 310014
China
Recruiting
Sir Run Run Shaw Hospital, Zhejiang University
Hangzhou, 310020
China
Recruiting
The First Affliated Hospital Of Nanchang University
Nanchang, 330006
China
Recruiting
Nanjing Drum Tower Hospital
Nanjing, 210008
China
Recruiting
Jiangsu Cancer Hospital
Nanjing, 210009
China
Recruiting
Renji Hospital, Shanghai Jiaotong University School of Medicine
ShangHai, 200127
China
Recruiting
Huadong Hospital Affiliated to Fudan University
Shanghai, 200400
China
Recruiting
Shengjing Hospital of China Medical University
Shenyang, 110004
China
Not yet recruiting
First Affiliated Hospital, Xi'an Jiaotong University
Xi'an, 710061
China
Recruiting
Institut de Cancérologie de l'Ouest (ICO)
Angers, 49055
France
Recruiting
Hopital Jean MINJOZ
Besancon Cedex, 25030
France
Recruiting
Institut Bergonié
Bordeaux, 33000
France
Recruiting
Centre Jean Perrin
Clermont Ferrand, 63011
France
Recruiting
Centre Georges-François Leclerc
Dijon, 21079
France
Not yet recruiting
Centre Oscar Lambret
Lille, 59020
France
Recruiting
Centre Leon Bérard
Lyon, 69008
France
Not yet recruiting
Hopital de la Timone
Marseille, 13005
France
Not yet recruiting
Institut Regional du Cancer de Montpellier Val d'Aurelle
Montpellier, 34298
France
Recruiting
Centre Antoine Lacassagne
Nice, 06189
France
Recruiting
Institut de Cancérologie du Gard
Nîmes, 30029
France
Recruiting
Hospital Saint-Louis
Paris Cedex 10, 75475
France
Terminated
Hopital Europeen Georges-Pompidou
Paris, 75015
France
Recruiting
Hospices Civils de Lyon HCL
Pierre-Bénite, 69495
France
Recruiting
CHU De Poitiers
Poitiers Cedex, 86021
France
Recruiting
Centre Hopitalier Inter-Communal De Cornouaille
Quimper, 29000
France
Recruiting
Centre Eugene Marquis
Rennes Cedex, 35062
France
Recruiting
I.C.O. René Gauducheau
Saint Herblain Cedex, 44805
France
Not yet recruiting
Institut de Cancérologie de Loire
Saint-Priest-en-Jarez, 42271
France
Recruiting
Hopitaux universitaires de Strasbourg
Strasbourg, 67091
France
Recruiting
Institut Claudius Regaud
Toulouse, 31059
France
Recruiting
Centre Les Dentellieres
Valenciennes, 59300
France
Recruiting
Institut Gustave Roussy
Villejuif, 94805
France
Recruiting
Vivantes Klinikum Am Urban
Berlin, 10967
Germany
Recruiting
Städtisches Klinikum Braunschweig gGmbH-Klinik für Urologie und Uroonkologie
Braunschweig, 38126
Germany
Not yet recruiting
Universitatsklinikum Carl Gustav Carcus Dresden
Dresden, 01307
Germany
Not yet recruiting
Universitaetsklinikum Duesseldorf
Duesseldorf, 40225
Germany
Not yet recruiting
Friedrich-Alexander Universitaet Urologische Universitaetskl
Erlangen, 91054
Germany
Not yet recruiting
Universitatsklinikum Frankfurt
Frankfurt, 60590
Germany
Not yet recruiting
Universitatsklinikum Freiburg
Freiburg, 79106
Germany
Recruiting
Universitätsmedizin Greifswald
Greifswald, 17475
Germany
Not yet recruiting
Universitätsmedizin Göttingen
Göttingen, 37099
Germany
Not yet recruiting
Asklepios Klinik Altona
Hamburg, 22763
Germany
Recruiting
Medizinische Hochschule Hannover
Hannover, 30625
Germany
Not yet recruiting
Universitätsklinikum des Saarlandes
Homburg/Saar, 66421
Germany
Withdrawn
Universitätsklinikum Schleswig Holstein Campus Lübeck
Lubeck, 23538
Germany
Not yet recruiting
Medizinische Fakultät Mannheim der Universität Heidelberg
Mannheim, 68167
Germany
Not yet recruiting
Universitaetsklinikum Muenster
Muenster, 48149
Germany
Recruiting
Studienpraxis Urologie Drs. Feyerabend
Nuertingen, 72622
Germany
Recruiting
Caritas-Krankenhaus St. Josef
Regensburg, 93053
Germany
Not yet recruiting
Universitaetsmedizin Rostock
Rostock, 18057
Germany
Not yet recruiting
MVZ-Onkologie Velbert GbR
Velbert, 42551
Germany
Not yet recruiting
Kliniken Nordoberpfalz AG/Klinikum Weiden
Weiden, 92637
Germany
Not yet recruiting
University General Hospital of Rio Patras
Achaïa, 26504
Greece
Recruiting
Errikos Dunant Hospital Center
Athens, 11526
Greece
Recruiting
Athens Medical Center
Athens, 15125
Greece
Recruiting
Metropolitan General A.E.
Athens, 15562
Greece
Recruiting
University of Athens Medical School - Regional General Hospi
Athina, 115 28
Greece
Recruiting
University Hospital Of Larissa
Larisa, 41110
Greece
Recruiting
Interbalkan European Medical Center
Thessaloniki, 14564
Greece
Recruiting
Euromedica General Clinic
Thessaloniki, 54645
Greece
Recruiting
'Papageorgiou' General Hospital of Thessaloniki
Thessaloniki, 56403
Greece
Recruiting
Semmelweis Egyetem
Budapest, 1082
Hungary
Recruiting
Orszagos Onkologiai Intezet
Budapest, 1122
Hungary
Recruiting
Uzsoki Utcai Korhaz
Budapest, H-1145
Hungary
Recruiting
Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz
Nyíregyháza, 04400
Hungary
Recruiting
Pécsi Tudományegyetem Klinikai Központ
Pécs, 7624
Hungary
Recruiting
Manipal Comprehensive Cancer Centre, Manipal Hospital
Bangalore, 560 017
India
Suspended
Apollo Specialty Hospital
Chennai, 600035
India
Suspended
Bhagwan Mahaveer Hospital & Research Centre
Jaipur, 302017
India
Suspended
Sahyadri Speciality Hospital
Pune, 411001
India
Suspended
Deenanath Mangeshkar Hospital and Research Centre
Pune, 411004
India
Suspended
Rambam Health Care Campus
Haifa, 31096
Israel
Recruiting
Hadassah Medical Center
Jerusalem, 91120
Israel
Recruiting
Meir Medical Center
Kfar Saba, 44281
Israel
Recruiting
Rabin Medical Center, Beilinson Hospital
Petach Tikvah, 49100
Israel
Recruiting
The Chaim Sheba Medical Center
Tel Hashomer, 52621
Israel
Recruiting
Assaf Harofeh Medical Center
Zerifin, 70300
Israel
Recruiting
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria
Alessandria, 15121
Italy
Not yet recruiting
Ospedale S. Donato - Asl 8 Arezzo
Arezzo, 52100
Italy
Recruiting
CRO, IRCCS, Istituto Nazionale Tumori
Aviano, 33081
Italy
Recruiting
Azienda Ospedaliera Papa Giovanni XXIII
Bergamo, 24127
Italy
Recruiting
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Presidio Spedali Civili
Brescia, 25123
Italy
Recruiting
Istituti Ospitalieri di Cremona, AO di Cremona
Cremona, 26100
Italy
Recruiting
Oncologia Medica
Firenze, 50139
Italy
Not yet recruiting
Policlinico Hospital San Martino- IRCCS for Oncology
Genova, 16132
Italy
Withdrawn
UOC Oncologia Ospedale Provinciale di Macerata
Macerata, 62100
Italy
Not yet recruiting
IRST Meldola - Forlì
Meldola, 47014
Italy
Recruiting
Fondazione IRCCS Istituto Nazionale dei Tumori
Milano, 20133
Italy
Recruiting
European Institute of Oncology
Milano, 20141
Italy
Recruiting
AOU Policlinico di Modena
Modena, 41124
Italy
Not yet recruiting
IRCCS-Fondazione Pascale
Napoli, 80131
Italy
Recruiting
Ospedale Maggiore della Carità
Novara, 28100
Italy
Recruiting
Aou San Luigi Gonzaga
Orbassano, 10043
Italy
Recruiting
Istituto Oncologico Veneto Iov Irccs Padova
Padova, 35128
Italy
Recruiting
AOU di Parma
Parma, 43126
Italy
Not yet recruiting
IRCCS Policlinico San Matteo
Pavia, 27100
Italy
Recruiting
Ist. Clinici Scientifici Maugeri - Unità Operativa di Oncolo
Pavia, 27100
Italy
Recruiting
Azienda Ospedaliero Universitaria Pisana
Pisa, 56126
Italy
Not yet recruiting
Usl 7 Siena - Ospedale Alta Valdelsa ASL TOSCANA SUD-EST
Poggibonsi (SI), 53100
Italy
Recruiting
Fondazione Policlinico Universitario A. Gemelli IRCCS
Roma, 00168
Italy
Not yet recruiting
Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria alle Scotte
Siena, 53100
Italy
Not yet recruiting
Oncologia Medica-Città Della Salute E Della Scienza Di Torino
Torino, 10123
Italy
Recruiting
Azienda Ospedaliero - Universitaria Ospedali Riuniti
Torrette Di Ancona, 60126
Italy
Recruiting
Chiba Cancer Center
Chiba, 260-8717
Japan
Recruiting
Hirosaki University School of Medicine & Hospital
Hirosaki, 036-8563
Japan
Recruiting
National Cancer Center Hospital East
Kashiwa, 277-8577
Japan
Recruiting
Kagawa University Hospital
Kita-Gun, 761-0793
Japan
Recruiting
Kobe City Medical Center General Hospital
Kobe, 650-0047
Japan
Recruiting
Dokkyo Medical University Saitama Medical Center
Koshigaya, 343-8555
Japan
Recruiting
National Shikoku Cancer Center
Matsuyama, 791-0280
Japan
Recruiting
University of Miyazaki Hospital
Miyazaki, 889-1692
Japan
Recruiting
Nagano Municipal Hospital
Nagano, 381-8551
Japan
Recruiting
Aichi Cancer Center Hospital
Nagoya-shi, 464-8681
Japan
Recruiting
Kinki University Hospital
Osaka-Sayama, 589-8511
Japan
Recruiting
Osaka International Cancer Institute
Osaka-shi, 541-8567
Japan
Recruiting
Osaka City University Hospital
Osaka, 545-8586
Japan
Recruiting
Kitasato University Hospital
Sagamihara, 252-0375
Japan
Recruiting
Toho University Sakura Medical Center
Sakura, 285-8741
Japan
Recruiting
National Hospital, Hokkaido Cancer Center
Sapporo, 003-0804
Japan
Recruiting
Tokyo Women's Medical University Hospital
Shinjuku-ku, 162-8666
Japan
Recruiting
University of Tsukuba Hospital
Tsukuba, 305-8576
Japan
Recruiting
Yamaguchi University Hospital
Ube, 755-8505
Japan
Recruiting
Yokohama City University Medical Center
Yokohama, 232-0024
Japan
Recruiting
Pusan National University Hospital.
Busan, 49241
Korea, Republic of
Recruiting
Chungnam National University Hospital
Daejeon, 35015
Korea, Republic of
Recruiting
National Cancer Center
Goyangsi, 410-769
Korea, Republic of
Recruiting
Gachon University Gil Medical Center
Incheon, 21565
Korea, Republic of
Recruiting
Seoul National University Bundang Hospital
Seongnam, 463-707
Korea, Republic of
Recruiting
Korea University Anam Hospital
Seoul, 02841
Korea, Republic of
Recruiting
Seoul National University Hospital
Seoul, 03080
Korea, Republic of
Recruiting
Severance Hospital, Yonsei University Health System
Seoul, 03722
Korea, Republic of
Recruiting
Samsung Medical Center
Seoul, 135-710
Korea, Republic of
Recruiting
Yonsei University Wonju Severance Christian Hospital
Wonju-si, 26426
Korea, Republic of
Recruiting
San Peregrino Cancer Center
Aguascalientes, 20230
Mexico
Recruiting
Centro Estatal de Cancerología de Chihuahua
Chihuahua, 31000
Mexico
Recruiting
St. Antonius Ziekenhuis Nieuwegein
Nieuwegein, 3430 EM
Netherlands
Recruiting
Radboud Umcn
Nijmegen, 6525 GA
Netherlands
Withdrawn
Hospital Lusíadas
Lisboa, 1500-458
Portugal
Not yet recruiting
H. Santa Maria - Centro Hospitalar de Lisboa Norte
Lisboa, 1649-035
Portugal
Not yet recruiting
Hospital Santo Antonio dos Capuchos
Lisboa, G1R 2J6
Portugal
Not yet recruiting
Champalimaud Foundation Champalimaud Centre
Lisbon, 1400-038
Portugal
Recruiting
Instituto Portugues de Oncologia
Porto, 4200072
Portugal
Not yet recruiting
Altai Regional Oncology Dispensary
Barnaul, 656049
Russian Federation
Recruiting
Chelyabinsk Regional Clinical Center Of Oncology And Nuclear Medicine
Chelyabinsk, 454087
Russian Federation
Recruiting
Ivanovo Regional Oncology Dispensary
Ivanovo, 153040
Russian Federation
Recruiting
Naval Clinical Hospital
Kaliningrad, 236029
Russian Federation
Not yet recruiting
City Clinical Hospital n.a. D.D.Pletnev
Moscow, 105077
Russian Federation
Not yet recruiting
FSBSI 'N. N. Blokhin Russian Cancer Research Center'
Moscow, 115478
Russian Federation
Not yet recruiting
Russian Scientific Center of Roentgenoradiology
Moscow, 117997
Russian Federation
Recruiting
Hertzen Oncology Research Institute
Moscow, 125284
Russian Federation
Recruiting
Privolzhsky District Medical Center under the Federal Medico-Biological Agency
Nizhni Novgorod, 603109
Russian Federation
Recruiting
National Medical Radiological Research Center
Obninsk, 249036
Russian Federation
Withdrawn
Clinical Oncology Dispensary
Omsk, 644013
Russian Federation
Recruiting
GBUZ of Stavropol region Pyatigorsk Oncological Dispensary
Pyatigorsk, 357502
Russian Federation
Recruiting
City Polyprofiled Hospital #2
Saint Petersburg, 194354
Russian Federation
Withdrawn
Private Medical Institution Euromedservice
Saint Petersburg, 196603
Russian Federation
Not yet recruiting
Pavlov First Saint Petersburg State Medical University
Saint Petersburg, 197022
Russian Federation
Completed
LLC 'Strategic Medical Systems'
Saint-Petersburg, 192148
Russian Federation
Recruiting
Clinical hopital n/a Petra velikogo
Saint-Petersburg, 195067
Russian Federation
Recruiting
FGBOU Vo Mordovian National Research State University N. A. N.P. Ogareva
Saransk, 430032
Russian Federation
Recruiting
Saratov State Medical University
Saratov, 410000
Russian Federation
Recruiting
GBUZ Oncology Centre #2 of Healthcare Department of Krasno
Sochi, 354057
Russian Federation
Not yet recruiting
Russian Scientific Center of Radiology and Surgical Technologies
St. Petersburg, 197758
Russian Federation
Recruiting
Saint-Petersburg Clinical Scientific And Practical Center For Special Types Of Medical Care
St.Petersburg, 197758
Russian Federation
Completed
Multifunctional clinical medical center 'Medical city'
Tyumen, 625041
Russian Federation
Recruiting
Bashkiria State Medical University
Ufa, 450000
Russian Federation
Not yet recruiting
Vologda Regional Oncological Dispensary
Vologda, 160012
Russian Federation
Not yet recruiting
Hosp. Univ. Infanta Cristina
Badajoz, 06006
Spain
Recruiting
Institut Català D'Oncologia-Hospital Universitari Germans Trias I Pujol
Badalona, 08916
Spain
Recruiting
Hosp. Clinic I Provincial de Barcelona
Barcelona, 08036
Spain
Recruiting
Hosp. de La Santa Creu I Sant Pau
Barcelona, 08041
Spain
Recruiting
Hosp. Reina Sofia
Córdoba, 14004
Spain
Recruiting
Hosp. Univ. Virgen de Las Nieves
Granada, 18014
Spain
Recruiting
Complejo Hospitalario de Jaen
Jaén, 23007
Spain
Recruiting
Hosp. Univ. Lucus Augusti
Lugo, 27003
Spain
Recruiting
Hosp. Gral. Univ. Gregorio Maranon
Madrid, 28009
Spain
Not yet recruiting
Centro Oncologico Md Anderson
Madrid, 28033
Spain
Withdrawn
Hosp. Univ. La Paz
Madrid, 28046
Spain
Recruiting
Hosp. Univ. Pta. de Hierro Majadahonda
Majadahonda, 28220
Spain
Recruiting
ALTHAIA, Xarxa Assistencial Universitària de Manresa
Manresa, 08243
Spain
Recruiting
Hosp. Virgen de La Victoria
Málaga, 29010
Spain
Withdrawn
Hosp. de Navarra
Pamplona, 31008
Spain
Recruiting
Hosp. Virgen Macarena
Sevilla, 41009
Spain
Recruiting
Hosp. Virgen Del Rocio
Sevilla, 41013
Spain
Recruiting
Hosp. Univ. I Politecni La Fe
Valencia, 46026
Spain
Recruiting
Hosp. Univ. Miguel Servet
Zaragoza, 50009
Spain
Recruiting
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, 807
Taiwan
Recruiting
Chi Mei Medical Center - Liu Ying
Liou Ying Township, 736
Taiwan
Recruiting
Chang Gung Medical Foundation
Niao-Sung Hsiang, 833
Taiwan
Recruiting
Taichung Veterans General Hospital
Taichung, 40705
Taiwan
Recruiting
National Cheng Kung University Hospital
Tainan, 70403
Taiwan
Recruiting
National Taiwan University Hospital
Taipei City, 10002
Taiwan
Recruiting
Mackay Memorial Hospital
Taipei, 10449
Taiwan
Recruiting
Taipei Veterans General Hospital
Taipei, 11217
Taiwan
Recruiting
Koo Foundation Sun Yat-Sen Cancer Center
Taipei, 11259
Taiwan
Recruiting
Chang-Gung Memorial Hospital, LinKou Branch
Taoyuan, 333
Taiwan
Recruiting
Baskent University Adana Practice and Research Center Kisla Health Campus
Adana, 01120
Turkey
Recruiting
Hacettepe University Medical Faculty
Ankara, 6100
Turkey
Recruiting
Bezmialem University Medical Faculty
Istanbul, 34093
Turkey
Recruiting
Istanbul University Cerrahpasa Medical Faculty
Istanbul, 34098
Turkey
Recruiting
Bakirkoy Training and Research Hospital
Istanbul, 34147
Turkey
Recruiting
Medipol Mega University Hospital
Istanbul, 34214
Turkey
Recruiting
Marmara University Medical Faculty
Istanbul, 34890
Turkey
Recruiting
Istanbul Medeniyet University Goztepe Training and Research Hospital
Istanbul, 81450
Turkey
Recruiting
Ege University
Izmir, 35100
Turkey
Recruiting
Dokuz Eylul Universitesi Tip Fakultesi
Izmir, 35340
Turkey
Recruiting
Kocaeli University Medical Faculty
Kocaeli,
Turkey
Recruiting
Inonu Universitesi Turgut Ozal Tip Merkezi, Ic Hastaliklari
Malatya, 44400
Turkey
Recruiting
Chernivtsi Regional Clinical Hospital
Chernivtsi, 58002
Ukraine
Withdrawn
MI Dnipropetrovsk Region Clinical Hospital n a I.I.Mechnikov
Dnipropetrovsk, 49005
Ukraine
Recruiting
Komunalnyi zaklad Miska bahatoprofilna klinichna likarnia #4
Dnipropetrovsk, 49102
Ukraine
Recruiting
Oblasnyi Klinichnyi Onkologichnyi Dyspanser
Dnipro, 49100
Ukraine
Recruiting
Oblasna klinichna likarnia - urolohichne viddilennia
Ivano-Frankivsk, 76018
Ukraine
Recruiting
Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval
Kharkiv, 61037
Ukraine
Not yet recruiting
Regional center of oncology
Kharkov, 61070
Ukraine
Recruiting
National Cancer Institute
Kyiv, 03022
Ukraine
Recruiting
State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center
Kyiv, 03115
Ukraine
Not yet recruiting
Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital'
Lviv, 79010
Ukraine
Not yet recruiting
Transkarpathian Regional University Oncology Clinic
Uzhgorod, 88000
Ukraine
Recruiting
Podilskyi Rehionalnyi Tsentr Onkolohii, Viddilennia Khimioterapii
Vinnytsia, 21029
Ukraine
Recruiting
Zaokod
Zaporizhzhia, 69040
Ukraine
Completed
Zaporizhzhia medical Academy of postgraduate education, Zaporizhzhia Regoinal Clinical Hospital
Zaporizhzhia, 69600
Ukraine
Completed
University Hospitals Bristol - Bristol Haematology & Oncolog
Bristol, BS2 8ED
United Kingdom
Recruiting
St Bartholomew's Hospital
London, EC1A 7BE
United Kingdom
Recruiting
Sarah Cannon Research Institute
London, W1G 6AD
United Kingdom
Recruiting
Charing Cross Hospital
London, W6 8RF
United Kingdom
Recruiting
The Christie NHS Foundation Trust - Christie Hospital
Manchester, M20 4BX
United Kingdom
Recruiting
Derriford Hospital-Department of Medical Oncology
Plymouth, PL6 8QH
United Kingdom
Recruiting
University of Sheffield
Sheffield, S10 2 RX
United Kingdom
Not yet recruiting
Southampton General Hospital
Southampton, SO16 6YD
United Kingdom
Recruiting
Royal Marsden Hospital
Sutton, SM2 5NG
United Kingdom
Recruiting