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BRIEF TITLE: Phase II Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Rare Genitourinary Tumors

A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC)


  • Org Study ID: NCI-2019-01266
  • Secondary ID: NCI-2019-01266,A031702,A031702,U10CA180821
  • NCT ID: NCT03866382
  • NCT Alias:
  • Sponsor: National Cancer Institute (NCI) - NIH
  • Source: National Cancer Institute (NCI)

Brief Summary

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that have spread to other places in the body. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib, nivolumab, and ipilimumab may work better in treating patients with genitourinary tumors that have no treatment options compared to giving cabozantinib, nivolumab, or ipilimumab alone.

Detailed Description


PRIMARY OBJECTIVES:

I. To evaluate the efficacy of cabozantinib s-malate (cabozantinib) combined with nivolumab
and ipilimumab in the first or second-line (and beyond) setting for patients within each of
the rare genitourinary (GU) variant histology group of interest, as measured by objective
response rate (ORR).

SECONDARY OBJECTIVES:

I. To estimate the progression-free survival (PFS) for patients treated with cabozantinib
combined with nivolumab and ipilimumab within each rare variant histology.

II. To estimate the overall survival (OS) for patients treated with cabozantinib combined
with nivolumab and ipilimumab within each rare variant histology.

III. To estimate the clinical benefit rate (defined as complete response [CR] or partial
response [PR] or stable disease [SD]) for patients treated with cabozantinib combined with
nivolumab and ipilimumab within each rare variant histology.

IV. To assess the safety of treating patients with rare variant histologies with cabozantinib
combined with nivolumab and ipilimumab.

V. To support tissue banking and collection of clinical follow-up data for GU tract rare
histological variants.

EXPLORATORY OBJECTIVES:

I. To assess effects of treatment in patients with bone-only disease by bone scan.

OUTLINE:

Patients receive cabozantinib orally (PO) once daily (QD) on days 1-21 of cycles 1-4 and on
days 1-28 of subsequent cycles. Patients also receive nivolumab intravenously (IV) over 30
minutes on day 1 and ipilimumab IV over 90 minutes on day 1 of cycles 1-4. Patients then
receive nivolumab IV over 30 minutes on day 1 of subsequent cycles. Treatment repeats every
21 days for cycles 1-4 and every 28 days for subsequent cycles for 2 years in the absence of
disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 2 months for 5 years.

Overal Status Start Date Phase Study Type
Recruiting April 12, 2019 Phase 2 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: Objective response rate (ORR)

Primary Outcome 1 - Time Frame: Up to 5 years

Condition:

  • Bladder Adenocarcinoma
  • Bladder Mixed Adenocarcinoma
  • Bladder Small Cell Carcinoma
  • Bladder Squamous Cell Carcinoma
  • Bone Lesion
  • Chromophobe Renal Cell Carcinoma
  • Infiltrating Bladder Lymphoepithelioma-Like Carcinoma
  • Infiltrating Bladder Urothelial Carcinoma
  • Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
  • Infiltrating Bladder Urothelial Carcinoma With Giant Cells
  • Infiltrating Bladder Urothelial Carcinoma, Nested Variant
  • Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
  • Kidney Medullary Carcinoma
  • Large Cell Neuroendocrine Carcinoma
  • Metastatic Bladder Carcinoma
  • Metastatic Bladder Large Cell Neuroendocrine Carcinoma
  • Metastatic Bladder Small Cell Carcinoma
  • Metastatic Bladder Squamous Cell Carcinoma
  • Metastatic Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant
  • Metastatic Infiltrating Bladder Urothelial Carcinoma, Lipid-Rich Variant
  • Metastatic Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant
  • Metastatic Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
  • Metastatic Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant
  • Metastatic Kidney Medullary Carcinoma
  • Metastatic Malignant Genitourinary System Neoplasm
  • Metastatic Penile Carcinoma
  • Metastatic Prostate Small Cell Carcinoma
  • Metastatic Sarcomatoid Renal Cell Carcinoma
  • Papillary Renal Cell Carcinoma
  • Sarcomatoid Renal Cell Carcinoma
  • Stage IV Bladder Cancer AJCC v8
  • Stage IV Penile Cancer AJCC v8
  • Stage IV Prostate Cancer AJCC v8
  • Stage IV Renal Cell Cancer AJCC v8
  • Stage IVA Bladder Cancer AJCC v8
  • Stage IVA Prostate Cancer AJCC v8
  • Stage IVB Bladder Cancer AJCC v8
  • Stage IVB Prostate Cancer AJCC v8
  • Testicular Leydig Cell Tumor
  • Testicular Sertoli Cell Tumor

Eligibility

Criteria:
Inclusion Criteria:

- Metastatic disease defined as new or progressive lesions on cross-sectional imaging or
bone scan. Patients must have at least:

- One measurable site of disease as per Response Evaluation Criteria in Solid
Tumors (RECIST) version (v) 1.1

- One bone lesion on bone scan (tec99 or sodium fluoride [NaF] positron emission
tomography [PET]/computed tomography [CT], CT, or magnetic resonance imaging
[MRI]) for the bone-only cohort

- Histologically confirmed diagnosis of metastatic: small cell carcinoma of the
bladder; adenocarcinoma of the bladder; squamous cell carcinoma of the bladder;
plasmacytoid urothelial carcinoma; any penile cancer; sarcomatoid renal cell
carcinoma; sarcomatoid urothelial carcinoma; renal medullary carcinoma or other
miscellaneous histologic variants of the urothelial carcinoma, such as, but not
limited to micropapillary, giant cell, lipid-rich, clear cell and nested
variants, large cell neuroendocrine carcinoma, lymphoepithelioma-like carcinoma
and mixed patterns will be considered, as well as small cell neuroendocrine
prostate cancer, testicular Sertoli or Leydig cell tumors, and papillary and
chromophobe renal cell carcinoma (RCC)

- Hematoxylin and eosin (H&E) slides from diagnostic tumor tissue for retrospective
central pathology review

- Patients may have received any number of prior anti-cancer treatments or be treatment
naive (with the exception of patients with small cell carcinoma of the bladder, whom
should have received a platinum-based combination regimen either as neoadjuvant,
adjuvant or first-line treatment)

- Patients must be able to swallow oral formulation of the tablets

- Karnofsky performance status >= 70%

- Absolute neutrophil count (ANC) >= 1,200/mcL

- Platelet count >= 75,000/mcL

- Total bilirubin =< 1.5 x upper limit of normal (ULN). For subjects with known
Gilbert's disease or similar syndrome with slow conjugation of bilirubin, total
bilirubin =< 3.0 mg/dL

- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x institutional
upper limit of normal (ULN) (or =< 5 x ULN for patients with liver metastases or
Gilbert's disease)

- Creatinine =< 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 40
mL/min/1.73 m^2 (calculated using the Chronic Kidney Disease Epidemiology [CKD-EPI]
equation or Cockcroft-Gault formula) for patients with creatinine levels above
institutional normal

- Hemoglobin >= 9 g/dL (transfusion of packed red blood cells [PRBCs] allowed)

- Serum albumin >= 2.8 g/dL

- Lipase and amylase =< 2.0 x ULN and no radiologic (on baseline anatomical imaging) or
clinical evidence of pancreatitis

- Prior treatment with MET or VEGFR inhibitors is allowed. However, prior cabozantinib
will not be allowed. Also, patients that have received both prior MET or VEGF and
prior PD-1/PD-L1/CTLA-4 (sequentially or in combination) are also not allowed

- Prior treatment with any therapy on the PD-1/PD-L1 axis or anti- CTLA-4/CTLA-4
inhibitors is allowed, either in the perioperative or in the metastatic setting.
However, patients that have received both prior MET or VEGF and prior
PD-1/PD-L1/CTLA-4 (sequentially or in combination) are not allowed

- Human immunodeficiency virus (HIV)-positive patients are eligible if on stable dose of
highly active antiretroviral therapy (HAART), no clinically significant drug-drug
interactions are anticipated with the current HAART regimen, CD4 counts are greater
than 350 and viral load is undetectable

- Patients with rheumatoid arthritis and other rheumatologic arthropathies, Sjogren's
syndrome and psoriasis controlled with topical medication only and patients with
positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies etc.
are eligible but should be considered for rheumatologic evaluation for the presence of
target organ involvement and potential need for systemic treatment

- Patients with vitiligo, endocrine deficiencies including thyroiditis managed with
replacement hormones or medications (e.g. thyroiditis managed with propylthiouracil
[PTU] or methimazole) including physiologic oral corticosteroids are eligible

- Patients who have evidence of active or acute diverticulitis, intra-abdominal abscess,
and gastrointestinal (GI) obstruction, within 12 months are not eligible

- Women of childbearing potential must have a negative pregnancy test =< 7 days prior to
registration

- Women of childbearing potential include women who have experienced menarche and
who have not undergone successful surgical sterilization (hysterectomy, bilateral
tubal ligation, or bilateral oophorectomy) or are not postmenopausal. Post
menopause is defined as amenorrhea >= 12 consecutive months. Note: women who have
been amenorrheic for 12 or more months are still considered to be of childbearing
potential if the amenorrhea is possibly due to prior chemotherapy, antiestrogens,
ovarian suppression or any other reversible reason

- Pregnant women may not participate in this study because with cabozantinib, nivolumab,
and ipilimumab have potential for teratogenic or abortifacient effects. Because there
is an unknown but potential risk for adverse events in nursing infants secondary to
treatment of the mother with cabozantinib, nivolumab, and ipilimumab, breastfeeding
should be discontinued if the mother is treated with these agents

- The patient has received no cytotoxic chemotherapy (including investigational
cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within 2
weeks before the first dose of study treatment

- The patient has received no radiation therapy:

- To the lungs and mediastinum or abdomen within 4 weeks before the first dose of
study treatment, or has ongoing complications, or is healing from prior radiation
therapy

- To brain metastasis within 3 weeks for whole-brain radiotherapy (WBXRT), and 2
weeks for stereotactic body radiation therapy (SBRT) before the first dose of
study treatment

- To any other site(s) within 2 weeks before the first dose of study treatment

- The patient has received no radionuclide treatment within 6 weeks of the first dose of
study treatment

- The patient has received no prior treatment with a small molecule kinase inhibitor
within 14 days or five half-lives of the compound or active metabolites, whichever is
longer, before the first dose of study treatment

- The patient has received no prior treatment with hormonal therapy within 14 days or
five half-lives of the compound or active metabolites, whichever is longer, before the
first dose of study treatment. Subjects receiving gonadotropin-releasing hormone
(GnRH) agonists and antagonists are allowed to participate

- The patient has not received any other type of investigational agent within 14 days
before the first dose of study treatment

- The patient must have recovered to baseline or Common Terminology Criteria for Adverse
Events (CTCAE) =< grade 1 from toxicity due to all prior therapies except alopecia,
neuropathy and other non-clinically significant adverse events (AEs) defined as lab
elevation with no associated symptoms or sequelae

- The patient may not have active brain metastases or epidural disease. Patients with
brain metastases previously treated with whole brain radiation or radiosurgery or
subjects with epidural disease previously treated with radiation or surgery who are
asymptomatic and do not require steroid treatment for at least 2 weeks before starting
study treatment are eligible. Neurosurgical resection of brain metastases or brain
biopsy is permitted if completed at least 3 months before starting study treatment.
Baseline brain imaging with contrast-enhanced computed tomography (CT) or magnetic
resonance imaging (MRI) scans for subjects with known brain metastases is required to
confirm eligibility

- No concomitant treatment with warfarin. Aspirin (up to 325 mg/day), thrombin or factor
Xa inhibitors, low-dose warfarin (=< 1 mg/day), prophylactic and therapeutic low
molecular weight heparin (LMWH) are permitted

- No chronic concomitant treatment with strong CYP3A4 inducers (e.g., dexamethasone,
phenytoin, carbamazepine, rifampin, rifabutin, rifapentine, phenobarbital, and St.
John's wort) or strong CYP3A4 inhibitors

- Because the lists of these agents are constantly changing, it is important to
regularly consult medical reference texts such as the Physicians' Desk Reference
may also provide this information. As part of the enrollment/informed consent
procedures, the patient will be counseled on the risk of interactions with other
agents, and what to do if new medications need to be prescribed or if the patient
is considering a new over-the-counter medicine or herbal product

- The patient has not experienced any of the following:

- Clinically-significant gastrointestinal bleeding within 6 months before the first
dose of study treatment

- Hemoptysis of >= 0.5 teaspoon (2.5 mL) of red blood per day within 1 months
before the first dose of study treatment

- Any other signs indicative of pulmonary hemorrhage within 3 months before the
first dose of study treatment

- The patient has no tumor invading any major blood vessels

- The patient has no evidence of tumor invading the GI tract (esophagus, stomach, small
or large bowel, rectum or anus), or any evidence of endotracheal or endobronchial
tumor within 28 days before the first dose of cabozantinib

- The patient has no uncontrolled, significant intercurrent or recent illness including,
but not limited to, the following conditions:

- Cardiovascular disorders including:

- Congestive heart failure (CHF): New York Heart Association (NYHA) class III
(moderate) or class IV (severe) at the time of screening.

- Concurrent uncontrolled hypertension defined as sustained blood pressure
(BP) > 150 mm Hg systolic, or > 90 mm Hg diastolic despite optimal
antihypertensive treatment within 7 days of the first dose of study
treatment

- The subject has a corrected QT interval calculated by the Fridericia formula
(QTcF) > 500 ms within 28 days before randomization. Note: if initial QTcF
is found to be > 500 ms, two additional electrocardiograms (EKGs) separated
by at least 3 minutes should be performed. If the average of these three
consecutive results for QTcF is =< 500 ms, the subject meets eligibility in
this regard

- Any history of congenital long QT syndrome

- Any of the following within 6 months before registration of study treatment:

- Unstable angina pectoris

- Clinically-significant cardiac arrhythmias (patients with atrial
fibrillation are eligible)

- Stroke (including transient ischemic attack [TIA], or other ischemic
event)

- Myocardial infarction

- Cardiomyopathy

- No significant gastrointestinal disorders particularly those associated with a
high risk of perforation or fistula formation including:

- Any of the following that have not resolved within 28 days before the first
dose of study treatment:

- Intra-abdominal tumor/metastases invading GI mucosa

- Active peptic ulcer disease

- Diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis,
or malabsorption syndrome

- None of the following within 1 year before the first dose of study
treatment:

- Abdominal fistula or genitourinary fistula

- Gastrointestinal perforation

- Bowel obstruction or gastric outlet obstruction

- Intra-abdominal abscess. Note: Complete resolution of an
intra-abdominal abscess must be confirmed prior to initiating treatment
with cabozantinib even if the abscess occurred more than 12 months
before the first dose of study treatment

- Disorders associated with a high risk of fistula formation including percutaneous
endoscopic gastrostomy (PEG) tube placement are not eligible

- No other clinically significant disorders such as:

- Severe active infection requiring IV systemic treatment within 14 days
before the first dose of study treatment

- Serious non-healing wound/ulcer/bone fracture within 28 days before the
first dose of study treatment

- History of organ or allogeneic stem cell transplant

- Concurrent uncompensated hypothyroidism or thyroid dysfunction within 7 days
before the first dose of study treatment (for asymptomatic patients with an
elevated thyroid-stimulating hormone [TSH], thyroid replacement may be
initiated if clinically indicated without delaying the start of study
treatment)

- No history of major surgery as follows:

- Major surgery within 3 months of the first dose of cabozantinib; however, if
there were no wound healing complications, patients with rapidly growing
aggressive cancers, may start as soon as 6 weeks if wound has completely
healed post-surgery

- Minor surgery within 1 month of the first dose of cabozantinib if there were
no wound healing complications or within 3 months of the first dose of
cabozantinib if there were wound complications excluding core biopsies and
mediport placement

- Complete wound healing from prior surgery must be confirmed before the first
dose of cabozantinib irrespective of the time from surgery

- No history of severe hypersensitivity reaction to any monoclonal antibody

- No evidence of active malignancy, requiring systemic treatment within 2 years of
registration

- No history of allergic reactions attributed to compounds of similar chemical or
biologic composition to cabozantinib, nivolumab, ipilimumab or other agents used in
study

- No positive test for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus
ribonucleic acid (HCV antibody) indicating acute or chronic infection

- No patients with active autoimmune disease or history of autoimmune disease that might
recur, which may affect vital organ function or require immune suppressive treatment
including systemic corticosteroids. These include, but are not limited to patients
with a history of immune related neurologic disease, multiple sclerosis, autoimmune
(demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic
autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue
diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis,
hepatitis; and patients with a history of toxic epidermal necrolysis (TEN),
Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the
risk of recurrence or exacerbation of disease
Show More

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Andrea B Apolo

Role: Principal Investigator

Affiliation: Alliance for Clinical Trials in Oncology

Locations

Facility Status Contact
Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Anchorage Radiation Therapy Center
Anchorage, Alaska 99504
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Kingman Regional Medical Center
Kingman, Arizona 86401
United States
Recruiting Site Public Contact
888-823-5923
ctsucontact@westat.com
Mayo Clinic Hospital
Phoenix, Arizona 85054
United States
Suspended
Mayo Clinic in Arizona
Scottsdale, Arizona 85259
United States
Suspended
Mercy Hospital Fort Smith
Fort Smith, Arkansas 72903
United States
Recruiting Site Public Contact
800-378-9373
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas 71913
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
PCR Oncology
Arroyo Grande, California 93420
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
United States
Recruiting Site Public Contact
818-847-4793
Najee.Boucher@providence.org
Epic Care-Dublin
Dublin, California 94568
United States
Recruiting Site Public Contact
925-875-1677
Bay Area Breast Surgeons Inc
Emeryville, California 94608
United States
Recruiting Site Public Contact
510-835-9900
Epic Care Partners in Cancer Care
Emeryville, California 94608
United States
Recruiting Site Public Contact
510-629-6682
Contra Costa Regional Medical Center
Martinez, California 94553-3156
United States
Recruiting Site Public Contact
925-957-5400
Alta Bates Summit Medical Center - Summit Campus
Oakland, California 94609
United States
Recruiting Site Public Contact
510-204-1414
Bay Area Tumor Institute
Oakland, California 94609
United States
Recruiting Site Public Contact
510-465-2242
lradke@bati.org
Epic Care Cyberknife Center
Walnut Creek, California 94597
United States
Recruiting Site Public Contact
510-465-8016
somega@bati.org
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado 80907
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Porter Adventist Hospital
Denver, Colorado 80210
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Mercy Medical Center
Durango, Colorado 81301
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Southwest Oncology PC
Durango, Colorado 81301
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Saint Anthony Hospital
Lakewood, Colorado 80228
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Littleton Adventist Hospital
Littleton, Colorado 80122
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Longmont United Hospital
Longmont, Colorado 80501
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado 80501
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Parker Adventist Hospital
Parker, Colorado 80138
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Saint Mary Corwin Medical Center
Pueblo, Colorado 81004
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
MedStar Georgetown University Hospital
Washington, District of Columbia 20007
United States
Recruiting Site Public Contact
202-444-2223
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
United States
Suspended
UF Cancer Center at Orlando Health
Orlando, Florida 32806
United States
Recruiting Site Public Contact
321-841-7246
CancerClinicalTrials@orlandohealth.com
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute
Boise, Idaho 83712
United States
Recruiting Site Public Contact
208-381-2774
eslinget@slhs.org
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Kootenai Medical Center
Coeur d'Alene, Idaho 83814
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Walter Knox Memorial Hospital
Emmett, Idaho 83617
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, Idaho 83619
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Idaho Urologic Institute-Meridian
Meridian, Idaho 83642
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, Idaho 83642
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Saint Alphonsus Medical Center-Nampa
Nampa, Idaho 83686
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, Idaho 83686
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Kootenai Cancer Center
Post Falls, Idaho 83854
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Kootenai Cancer Clinic
Sandpoint, Idaho 83864
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, Idaho 83301
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Rush - Copley Medical Center
Aurora, Illinois 60504
United States
Recruiting Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
United States
Recruiting Site Public Contact
618-457-5200
clinical.research@sih.net
SIH Cancer Institute
Carterville, Illinois 62918
United States
Recruiting Site Public Contact
618-985-3333
clinical.research@sih.net
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
University of Illinois
Chicago, Illinois 60612
United States
Recruiting Site Public Contact
312-355-3046
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Recruiting Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu
Carle on Vermilion
Danville, Illinois 61832
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Recruiting Site Public Contact
815-285-7800
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United States
Recruiting Site Public Contact
309-344-2831
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Loyola University Medical Center
Maywood, Illinois 60153
United States
Recruiting Site Public Contact
708-226-4357
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois 60160
United States
Recruiting Site Public Contact
708-450-4554
Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
United States
Recruiting Site Public Contact
618-242-4600
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
Recruiting Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
Recruiting Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Peoria, Illinois 61636
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Valley Radiation Oncology
Peru, Illinois 61354
United States
Recruiting Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Recruiting Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
United States
Recruiting Site Public Contact
800-444-7541
Memorial Medical Center
Springfield, Illinois 62781
United States
Recruiting Site Public Contact
217-788-3528
Cancer Care Specialists of Illinois-Swansea
Swansea, Illinois 62226
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Southwest Illinois Health Services LLP
Swansea, Illinois 62226
United States
Recruiting Site Public Contact
618-236-1000
lynns@thecancercenter.com
Carle Cancer Center
Urbana, Illinois 61801
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
The Carle Foundation Hospital
Urbana, Illinois 61801
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
United States
Recruiting Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com
Reid Health
Richmond, Indiana 47374
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Mary Greeley Medical Center
Ames, Iowa 50010
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC - Ames
Ames, Iowa 50010
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC-Boone
Boone, Iowa 50036
United States
Recruiting Site Public Contact
515-956-4132
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa 50325
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Alegent Health Mercy Hospital
Council Bluffs, Iowa 51503
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa 50314
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC-Jefferson
Jefferson, Iowa 50129
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC-Marshalltown
Marshalltown, Iowa 50158
United States
Recruiting Site Public Contact
515-956-4132
Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Flaget Memorial Hospital
Bardstown, Kentucky 40004
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Commonwealth Cancer Center-Corbin
Corbin, Kentucky 40701
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky 40504
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Saint Joseph Hospital East
Lexington, Kentucky 40509
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Saint Joseph London
London, Kentucky 40741
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Jewish Hospital
Louisville, Kentucky 40202
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Saints Mary and Elizabeth Hospital
Louisville, Kentucky 40215
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Jewish Hospital Medical Center Northeast
Louisville, Kentucky 40245
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Jewish Hospital Medical Center South
Shepherdsville, Kentucky 40165
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
East Jefferson General Hospital
Metairie, Louisiana 70006
United States
Recruiting Site Public Contact
504-210-3539
emede1@lsuhsc.edu
LSU Healthcare Network / Metairie Multi-Specialty Clinic
Metairie, Louisiana 70006
United States
Recruiting Site Public Contact
504-210-3539
emede1@lsuhsc.edu
Louisiana State University Health Science Center
New Orleans, Louisiana 70112
United States
Recruiting Site Public Contact
504-210-3539
emede1@lsuhsc.edu
Lahey Hospital and Medical Center
Burlington, Massachusetts 01805
United States
Recruiting Site Public Contact
781-744-8027
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 48183
United States
Recruiting Site Public Contact
313-916-3721
CTOResearch@hfhs.org
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
United States
Recruiting Site Public Contact
313-916-3721
CTOResearch@hfhs.org
Henry Ford Medical Center-Fairlane
Dearborn, Michigan 48126
United States
Recruiting Site Public Contact
313-916-3721
CTOResearch@hfhs.org
Henry Ford Hospital
Detroit, Michigan 48202
United States
Recruiting Site Public Contact
313-916-3721
CTOResearch@hfhs.org
Allegiance Health
Jackson, Michigan 49201
United States
Recruiting Site Public Contact
313-916-3721
CTOResearch@hfhs.org
Henry Ford Medical Center-Columbus
Novi, Michigan 48377
United States
Recruiting Site Public Contact
313-916-3721
CTOResearch@hfhs.org
Huron Medical Center PC
Port Huron, Michigan 48060
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Lake Huron Medical Center
Port Huron, Michigan 48060
United States
Suspended
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
United States
Recruiting Site Public Contact
313-916-3721
CTOResearch@hfhs.org
Fairview Ridges Hospital
Burnsville, Minnesota 55337
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Cambridge Medical Center
Cambridge, Minnesota 55008
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview-Southdale Hospital
Edina, Minnesota 55435
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Unity Hospital
Fridley, Minnesota 55432
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Maple Grove Medical Center
Maple Grove, Minnesota 55369
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Health Partners Inc
Minneapolis, Minnesota 55454
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Monticello Cancer Center
Monticello, Minnesota 55362
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
New Ulm Medical Center
New Ulm, Minnesota 56073
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Northland Medical Center
Princeton, Minnesota 55371
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Mayo Clinic
Rochester, Minnesota 55905
United States
Recruiting Site Public Contact
855-776-0015
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Regions Hospital
Saint Paul, Minnesota 55101
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
United Hospital
Saint Paul, Minnesota 55102
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Lakeview Hospital
Stillwater, Minnesota 55082
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Ridgeview Medical Center
Waconia, Minnesota 55387
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Rice Memorial Hospital
Willmar, Minnesota 56201
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Lakes Medical Center
Wyoming, Minnesota 55092
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
University of Mississippi Medical Center
Jackson, Mississippi 39216
United States
Recruiting Site Public Contact
601-815-6700
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri 63011
United States
Recruiting Site Public Contact
314-251-7058
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri 63628
United States
Recruiting Site Public Contact
314-996-5569
Cox Cancer Center Branson
Branson, Missouri 65616
United States
Recruiting Site Public Contact
417-269-4520
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Recruiting Site Public Contact
573-334-2230
sfmc@sfmc.net
Southeast Cancer Center
Cape Girardeau, Missouri 63703
United States
Recruiting Site Public Contact
573-651-5550
Capital Region Southwest Campus
Jefferson City, Missouri 65109
United States
Recruiting Site Public Contact
573-632-4814
swooden@mail.crmc.org
Freeman Health System
Joplin, Missouri 64804
United States
Recruiting Site Public Contact
417-347-4030
LJCrockett@freemanhealth.com
Mercy Hospital Joplin
Joplin, Missouri 64804
United States
Recruiting Site Public Contact
417-556-3074
esmeralda.carrillo@mercy.net
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri 65401
United States
Recruiting Site Public Contact
573-458-7504
jrichards@research.pcrmc.com
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
United States
Recruiting Site Public Contact
573-458-7504
jrichards@research.pcrmc.com
Heartland Regional Medical Center
Saint Joseph, Missouri 64507
United States
Recruiting Site Public Contact
816-271-7937
linda.schumacher@mymlc.com
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri 63109
United States
Recruiting Site Public Contact
314-353-1870
Mercy Hospital South
Saint Louis, Missouri 63128
United States
Recruiting Site Public Contact

janet.lesko@mercy.net
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
United States
Recruiting Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
United States
Recruiting Site Public Contact
314-251-7066
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Recruiting Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield, Missouri 65804
United States
Recruiting Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield, Missouri 65807
United States
Recruiting Site Public Contact
417-269-4520
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
Recruiting Site Public Contact
314-996-5569
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri 63127
United States
Recruiting Site Public Contact
314-996-5569
Mercy Hospital Washington
Washington, Missouri 63090
United States
Recruiting Site Public Contact
636-390-1600
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Recruiting Site Public Contact
800-996-2663
research@billingsclinic.org
Bozeman Deaconess Hospital
Bozeman, Montana 59715
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Great Falls Clinic
Great Falls, Montana 59405
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Saint Peter's Community Hospital
Helena, Montana 59601
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Kalispell Regional Medical Center
Kalispell, Montana 59901
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Missoula, Montana 59802
United States
Recruiting Site Public Contact
406-327-3118
amy.hanneman@providence.org
Community Medical Hospital
Missoula, Montana 59804
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
CHI Health Saint Francis
Grand Island, Nebraska 68803
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
CHI Health Good Samaritan
Kearney, Nebraska 68847
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska 68510
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Nebraska Methodist Hospital
Omaha, Nebraska 68114
United States
Recruiting Site Public Contact
402-354-5144
Alegent Health Immanuel Medical Center
Omaha, Nebraska 68122
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska 68124
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Alegent Health Lakeside Hospital
Omaha, Nebraska 68130
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Creighton University Medical Center
Omaha, Nebraska 68131
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Midlands Community Hospital
Papillion, Nebraska 68046
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Carson Tahoe Regional Medical Center
Carson City, Nevada 89703
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Cancer and Blood Specialists-Henderson
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Cancer Center-Henderson
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
OptumCare Cancer Care at Seven Hills
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
21st Century Oncology-Henderson
Henderson, Nevada 89074
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada 89074
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Urology - Pebble
Henderson, Nevada 89074
United States
Recruiting Site Public Contact

research@sncrf.org
Las Vegas Urology - Pecos
Las Vegas, Nevada 89074
United States
Recruiting Site Public Contact

research@sncrf.org
Desert West Surgery
Las Vegas, Nevada 89102
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
University Medical Center of Southern Nevada
Las Vegas, Nevada 89102
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Hope Cancer Care of Nevada
Las Vegas, Nevada 89103
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Cancer and Blood Specialists-Shadow
Las Vegas, Nevada 89106
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
OptumCare Cancer Care at Oakey
Las Vegas, Nevada 89106
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada 89106
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
21st Century Oncology
Las Vegas, Nevada 89109
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, Nevada 89109
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Sunrise Hospital and Medical Center
Las Vegas, Nevada 89109
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, Nevada 89113
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada 89119
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
21st Century Oncology-Vegas Tenaya
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Ann M Wierman MD LTD
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Cancer and Blood Specialists-Tenaya
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Urology - Cathedral Rock
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact

research@sncrf.org
Las Vegas Urology - Smoke Ranch
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact

research@smcrf.org
OptumCare Cancer Care at MountainView
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada 89135
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada 89144
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada 89144
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Summerlin Hospital Medical Center
Las Vegas, Nevada 89144
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada 89148-2405
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
21st Century Oncology-Fort Apache
Las Vegas, Nevada 89148
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89148
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, Nevada 89149
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada 89169
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
University Cancer Center
Las Vegas, Nevada 89169
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada 89048
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Renown Regional Medical Center
Reno, Nevada 89502
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Saint Mary's Regional Medical Center
Reno, Nevada 89503
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Radiation Oncology Associates
Reno, Nevada 89509
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Recruiting Site Public Contact
800-767-9355
askroswell@roswellpark.org
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York 10032
United States
Recruiting Site Public Contact
212-305-6361
nr2616@cumc.columbia.edu
University of Rochester
Rochester, New York 14642
United States
Recruiting Site Public Contact
585-275-5830
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Recruiting Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
United States
Recruiting Site Public Contact
828-696-4716
karen.morris@unchealth.unc.edu
Indu and Raj Soin Medical Center
Beavercreek, Ohio 45431
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Strecker Cancer Center-Belpre
Belpre, Ohio 45714
United States
Recruiting Site Public Contact
800-523-3977
sheree@columbusccop.org
Saint Elizabeth Boardman Hospital
Boardman, Ohio 44512
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio 45459
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Adena Regional Medical Center
Chillicothe, Ohio 45601
United States
Recruiting Site Public Contact
877-779-7585
sheree@columbusccop.org
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio 45220
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio 45236
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Bethesda North Hospital
Cincinnati, Ohio 45242
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
TriHealth Cancer Institute-Westside
Cincinnati, Ohio 45247
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio 45255
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Mount Carmel East Hospital
Columbus, Ohio 43213
United States
Recruiting Site Public Contact
614-488-2118
sheree@columbusccop.org
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio 43214
United States
Recruiting Site Public Contact
614-488-2118
sheree@columbusccop.org
Riverside Methodist Hospital
Columbus, Ohio 43214
United States
Recruiting Site Public Contact
614-566-4475
sheree@columbusccop.org
Grant Medical Center
Columbus, Ohio 43215
United States
Recruiting Site Public Contact
614-566-4475
sheree@columbusccop.org
The Mark H Zangmeister Center
Columbus, Ohio 43219
United States
Recruiting Site Public Contact
614-488-2118
sheree@columbusccop.org
Mount Carmel Health Center West
Columbus, Ohio 43222
United States
Recruiting Site Public Contact
614-234-5433
sheree@columbusccop.org
Doctors Hospital
Columbus, Ohio 43228
United States
Recruiting Site Public Contact
614-566-3275
sheree@columbusccop.org
Good Samaritan Hospital - Dayton
Dayton, Ohio 45406
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Miami Valley Hospital
Dayton, Ohio 45409
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Dayton Physician LLC-Miami Valley Hospital North
Dayton, Ohio 45415
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Miami Valley Hospital North
Dayton, Ohio 45415
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Delaware Health Center-Grady Cancer Center
Delaware, Ohio 43015
United States
Recruiting Site Public Contact
740-615-0227
sheree@columbusccop.org
Grady Memorial Hospital
Delaware, Ohio 43015
United States
Recruiting Site Public Contact
740-615-2403
sheree@columbusccop.org
Dublin Methodist Hospital
Dublin, Ohio 43016
United States
Recruiting Site Public Contact
800-752-9119
sheree@columbusccop.org
Armes Family Cancer Center
Findlay, Ohio 45840
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Blanchard Valley Hospital
Findlay, Ohio 45840
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Orion Cancer Care
Findlay, Ohio 45840
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Dayton Physicians LLC-Atrium
Franklin, Ohio 45005
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Central Ohio Breast and Endocrine Surgery
Gahanna, Ohio 43230
United States
Recruiting Site Public Contact
614-488-2745
sheree@columbusccop.org
Dayton Physicians LLC-Wayne
Greenville, Ohio 45331
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Wayne Hospital
Greenville, Ohio 45331
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Greater Dayton Cancer Center
Kettering, Ohio 45409
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
First Dayton Cancer Care
Kettering, Ohio 45420
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Kettering Medical Center
Kettering, Ohio 45429
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Fairfield Medical Center
Lancaster, Ohio 43130
United States
Recruiting Site Public Contact
740-687-8863
sheree@columbusccop.org
OhioHealth Mansfield Hospital
Mansfield, Ohio 44903
United States
Recruiting Site Public Contact
419-526-8018
sheree@columbusccop.org
Marietta Memorial Hospital
Marietta, Ohio 45750
United States
Recruiting Site Public Contact
800-523-3977
sheree@columbusccop.org
OhioHealth Marion General Hospital
Marion, Ohio 43302
United States
Recruiting Site Public Contact
614-488-2118
sheree@columbusccop.org
Knox Community Hospital
Mount Vernon, Ohio 43050
United States
Recruiting Site Public Contact
740-393-9000
sheree@columbusccop.org
Licking Memorial Hospital
Newark, Ohio 43055
United States
Recruiting Site Public Contact
740-348-4000
sheree@columbusccop.org
Newark Radiation Oncology
Newark, Ohio 43055
United States
Recruiting Site Public Contact
614-488-2118
sheree@columbusccop.org
Southern Ohio Medical Center
Portsmouth, Ohio 45662
United States
Recruiting Site Public Contact
614-488-2118
sheree@columbusccop.org
Springfield Regional Cancer Center
Springfield, Ohio 45504
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Springfield Regional Medical Center
Springfield, Ohio 45505
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Dayton Physicians LLC-Upper Valley
Troy, Ohio 45373
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Upper Valley Medical Center
Troy, Ohio 45373
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Saint Joseph Warren Hospital
Warren, Ohio 44484
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Saint Ann's Hospital
Westerville, Ohio 43081
United States
Recruiting Site Public Contact
614-234-5433
sheree@columbusccop.org
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio 44501
United States
Recruiting Site Public Contact
937-775-1350
som_dcop@wright.edu
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio 43701
United States
Recruiting Site Public Contact
740-454-5232
sheree@columbusccop.org
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
United States
Recruiting Site Public Contact
877-231-4440
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Recruiting Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
United States
Recruiting Site Public Contact
405-752-3402
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma 74146
United States
Recruiting Site Public Contact
918-505-3200
Saint Alphonsus Medical Center-Baker City
Baker City, Oregon 97814
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Charles Health System
Bend, Oregon 97701
United States
Recruiting Site Public Contact
541-706-2909
nosall@stcharleshealthcare.org
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Providence Oncology and Hematology Care Southeast
Clackamas, Oregon 97015
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Bay Area Hospital
Coos Bay, Oregon 97420
United States
Recruiting Site Public Contact
541-269-8392
cherie.cox@bayareahospital.org
Providence Newberg Medical Center
Newberg, Oregon 97132
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Saint Alphonsus Medical Center-Ontario
Ontario, Oregon 97914
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Providence Portland Medical Center
Portland, Oregon 97213
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Oregon Health and Science University
Portland, Oregon 97239
United States
Recruiting Site Public Contact
503-494-1080
trials@ohsu.edu
Saint Charles Health System-Redmond
Redmond, Oregon 97756
United States
Recruiting Site Public Contact
541-706-2909
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
Recruiting Site Public Contact
412-647-8073
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania 15232
United States
Recruiting Site Public Contact
412-621-2334
Saint Joseph Regional Cancer Center
Bryan, Texas 77802
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
Recruiting Site Public Contact
214-648-7097
canceranswerline@UTSouthwestern.edu
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas 76104
United States
Recruiting Site Public Contact
214-648-7097
canceranswerline@UTSouthwestern.edu
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas 75080
United States
Recruiting Site Public Contact
214-648-0225
hrpp@utsouthwestern.edu
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
United States
Recruiting Site Public Contact
360-715-4133
mjohnson9@peacehealth.org
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington 98310
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Harrison Medical Center
Bremerton, Washington 98310
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Highline Medical Center-Main Campus
Burien, Washington 98166
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Saint Elizabeth Hospital
Enumclaw, Washington 98022
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Providence Regional Cancer Partnership
Everett, Washington 98201
United States
Recruiting Site Public Contact
425-261-3529
marilyn.birchman@providence.org
Saint Francis Hospital
Federal Way, Washington 98003
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
United States
Recruiting Site Public Contact
509-783-4637
research@kadlecmed.org
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
Saint Clare Hospital
Lakewood, Washington 98499
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
PeaceHealth Saint John Medical Center
Longview, Washington 98632
United States
Recruiting Site Public Contact
360-514-2016
kmakin-bond@peacehealth.org
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, Washington 98370
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
Valley Medical Center
Renton, Washington 98055
United States
Recruiting Site Public Contact
425-228-3440
research@valleymed.org
Pacific Gynecology Specialists
Seattle, Washington 98104
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Seattle, Washington 98122-4307
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
United States
Recruiting Site Public Contact
360-788-8240
Providence Regional Cancer System-Shelton
Shelton, Washington 98584
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
Franciscan Research Center-Northwest Medical Plaza
Tacoma, Washington 98405
United States
Recruiting Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org
PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
United States
Recruiting Site Public Contact
360-514-3940
kmakin-bond@peacehealth.org
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
United States
Recruiting Site Public Contact
509-897-5993
Cheryl.Dodd@providence.org
Providence Regional Cancer System-Yelm
Yelm, Washington 98597
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin 54701
United States
Suspended
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
Recruiting Site Public Contact

research.institute@phci.org
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Recruiting Site Public Contact
262-928-7878
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
United States
Recruiting Site Public Contact
262-928-7632
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
Recruiting Site Public Contact
262-928-5539
Chanda.miller@phci.org
Billings Clinic-Cody
Cody, Wyoming 82414
United States
Recruiting Site Public Contact
800-996-2663
research@billingsclinic.org
Welch Cancer Center
Sheridan, Wyoming 82801
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org