Primary Outcomes:

Primary Outcome 1 - Measure: Safety and Tolerability of CDX-1140 as assessed by CTCAE v5.0

Primary Outcome 1 - Time Frame: Within 35 days after first dose

Condition:

• Melanoma
• Non-small Cell Lung Cancer
• Breast Cancer
• Gastric Cancer
• Renal Cell Carcinoma
• Ovarian Cancer
• Cholangiocarcinoma
• Bladder Urothelial Carcinoma
• Pancreatic Adenocarcinoma
• Colorectal Cancer
• Esophageal Cancer
• Hepatic Cancer
• Head and Neck Cancer
• Primary Peritoneal Cancer
• Fallopian Tube Cancer
• Other Solid Tumors
• Diffuse Large B-cell Lymphoma (DLBCL)
• Mantle Cell Lymphoma
• Indolent B-cell Lymphomas
• Non-Hodgkin Lymphoma

Eligibility

Criteria:
Inclusion Criteria:

1. Diagnosed with one of the following:

- Recurrent, locally advanced or metastatic melanoma (including mucosal and/or
ocular), bladder/urothelial, non-small cell lung cancer, pancreatic
adenocarcinoma, breast, colorectal, gastric, esophageal, renal cell, hepatic,
ovarian fallopian or primary peritoneal carcinoma, head and neck, and
cholangiocarcinoma. Additional tumor types (except primary CNS tumors) may be
enrolled after discussion with, and approval from, the medical monitor.

- Advanced diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma, or indolent
B-cell lymphoma

2. Criteria A and B:

A. For patients with solid tumors:

- Must have received all standard of care therapies (approved or unapproved) as
deemed appropriate by the treating physician

- Patients are not required to have all approved therapies in a particular class of
drugs (e.g. all approved tyrosine kinase inhibitors for patients with renal cell
carcinoma or all approved checkpoint blockade antibodies for patients with
melanoma)

- Patients who refuse standard therapy are excluded from the study

B. For patients with lymphoma: Must have received ≥ 1 prior systemic therapy

3. Measurable disease.

4. Life expectancy ≥ 12 weeks.

5. If of childbearing potential (male or female), agrees to practice an effective form of
contraception during study treatment and for at least 3 months following last
treatment.

6. Willingness to undergo a pre-treatment and on-treatment biopsy, if required.

Exclusion Criteria:

1. History of severe hypersensitivity reactions to other monoclonal antibodies.

2. Previous treatment with any anti-CD40 antibody or with FLT3L.

3. Received any antibody targeting T-cell check point or co-stimulation pathways within 4
weeks, received any other monoclonal antibody within 4 weeks, and all other
immunotherapy (tumor vaccine, cytokine, or growth factor) within 2 weeks prior to
study treatment.

4. Prior T-cell or other cell-based therapies within 12 weeks (or 2 weeks if patient
experienced disease progression on the prior treatment)

5. For lymphoma patients:

- Prior allogenic stem cell transplantation

- Patients who have received autologous stem cell transplant ≤ 12 weeks prior to
the first dose of study drug.

6. Chemotherapy within 21 days (6 weeks for nitrosoureas) or at least 5 half-lives
(whichever is longer) prior to study treatment.

7. Received any kinase inhibitors within 2 weeks prior to study treatment.

8. Systemic radiation therapy within 4 weeks, prior focal radiotherapy within 2 weeks, or
radiopharmaceuticals (strontium, samarium) within 8 weeks prior to study treatment.

9. Major surgery within 4 weeks prior to study treatment.

10. Use of immunosuppressive medications within 4 weeks or systemic corticosteroids within
2 weeks prior to study treatment.

11. Other prior malignancy, except for adequately treated basal or squamous cell skin
cancer or in situ cancers. For all other cancers, the patient must be disease-free for
at least 3 years to be allowed to enroll.

12. Active, untreated central nervous system metastases.

13. Active autoimmune disease or documented history of autoimmune disease.

14. Active infection requiring systemic therapy, known infection of HIV, Hepatitis B, or
Hepatitis C.

15. Significant cardiovascular disease including Congestive Heart Failure or poorly
controlled hypertension.

There are additional criteria your study doctor will review with you to confirm your
eligibility for the study.
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Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No