Primary Outcomes:

Primary Outcome 1 - Measure: Number of participants with Dose-limiting toxicities (DLT) for Dose Escalation and Dose Finding

Primary Outcome 1 - Time Frame: Baseline up to 28 Days (Cycle 1)

Primary Outcome 2 - Measure: Number of Participants With Clinically Significant Change From Baseline in Laboratory Abnormalities

Primary Outcome 2 - Time Frame: Baseline up to approximately 24 months

Primary Outcome 3 - Measure: Number of Participants With Adverse Events (AEs) According to Severity

Primary Outcome 3 - Time Frame: Baseline up to approximately 24 months

Primary Outcome 4 - Measure: Number of Participants With Adverse Events (AEs) According to Seriousness

Primary Outcome 4 - Time Frame: Baseline up to up to approximately 24 months

Primary Outcome 5 - Measure: Number of Participants With Adverse Events (AEs) by Relationship

Primary Outcome 5 - Time Frame: Baseline up to approximately 24 months

Primary Outcome 6 - Measure: Progression-Free Survival (PFS) for Dose Expansion

Primary Outcome 6 - Time Frame: Baseline up to 24 Months

Primary Outcome 7 - Measure: Objective Response Rate - Percentage of Participants With Objective Response in Dose Expansion

Primary Outcome 7 - Time Frame: Baseline up to 24 months

Primary Outcome 8 - Measure: Duration of Response (DR) for Dose Expansion

Primary Outcome 8 - Time Frame: Baseline up to 24 Months

Condition:

• Squamous Cell Carcinoma of the Head and Neck
• Renal Cell Carcinoma
• Ovarian Cancer
• Gastric Cancer
• Esophageal Cancer
• Lung Squamous Cell Carcinoma
• Pancreatic Cancer
• Bile Duct Cancer
• Endometrial Cancer
• Melanoma Cancer
• Urothelial Cancer

Eligibility

Criteria:
Inclusion Criteria:

- Histological or cytological diagnosis of SCCHN, RCC (clear cell and papillary cell),
ovarian, gastric, esophageal (adeno and squamous), lung squamous cell, pancreatic and
biliary duct, endometrial, melanoma, or urothelial cancer.

- Adequate bone marrow, kidney and liver function.

- Performance status of 0 or 1.

Exclusion Criteria:

- Participant disease status is suitable for local therapy administered with curative
intent.

- Hypertension that cannot be controlled by medications.
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Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No