Primary Outcomes:

Primary Outcome 1 - Measure: Number of participants with Dose-Limiting Toxicities (DLT)

Primary Outcome 1 - Time Frame: First 8 weeks of treatment (Combination A-D) First 4 weeks of treatment (CombinationF)

Primary Outcome 2 - Measure: Objective Response - Number of Participants With Objective Response

Primary Outcome 2 - Time Frame: Baseline up to approximately 24 months

Condition:

• Advanced Cancer

Eligibility

Criteria:
Inclusion Criteria:

- Histological or cytological diagnosis of advanced/metastatic solid tumor. Measurable
disease by RECIST 1.1 with at least 1 measurable lesion that has not been previously
irradiated. Availability of tumor specimen taken within 1 year prior to study entry,
with no intervening systemic anti-cancer therapy. No prior PD-1/PDL-1 therapy allowed.
Combination A: Phase 1b, patients with NSCLC that have progressed on standard therapy
or for which no standard therapy is available, and Phase 2, patients with NSCLC,
melanoma, SCCHN, TNBC in any line of therapy, SCLC, 1st line NSCLC. 1st line NSCLC
must demonstrate to express PD-L1. Activating EGFR mutation, ALK, ROS1
translocation/rearrangements are not permitted. Combination B: Phase 1b, patients with
advanced solid tumors (NSCLC, SCCHN, melanoma) that have progressed on standard
therapy or for which no standard therapy is available, and Phase 2, patients with
NSCLC, melanoma, or SCCHN. Up to 2 lines of prior therapy in advanced/metastatic
disease setting allowed. Activating EGFR mutation, ALK, ROS1
translocation/rearrangements are not permitted. Combination C: Ovarian cancer, SCCHN,
NSCLC, gastric cancer, platinum resistant ovarian cancer. Up to 2 lines of prior
therapy in advanced/metastatic disease setting allowed. TGCT/PVNS that is either
inoperable or requires extensive resection. Prior treatment with agents targeting
CSF-1/CSF-1R not allowed. NSCLC activating EGFR mutation, ALK, ROS1
translocation/rearrangements are not permitted. Combination D: NSCLC, melanoma, SCCHN,
bladder cancer. NSCLC activating EGFR mutation, ALK, ROS1 translocation/rearrangements
are not permitted. Up to 2 lines of prior therapy in advanced/metastatic disease
setting allowed. Combination F: Recurrent or metastatic SCCHN. One to three prior
lines of systemic therapy for advanced stage or metastatic disease. Patients must have
received anti PD-1/PD-L1 containing therapy (requires at least two doses of PD-1/PD-L1
agent).Disease progression no earlier than 6 weeks from initiation of the latest
anticancer therapy. Evidence of radiologic progression is required. • Patient must be
a candidate for intralesional administration with at least one tumor lesion which can
be injected safely.

- ECOG performance status 0 or 1

- Estimated life expectancy of at least 3 months

- Adequate bone marrow, renal, and liver function

- Resolved acute effects of prior therapy

- Negative serum pregnancy test at screening

- Male and female patients able to have children must agree to use at least 1 highly
effective method of contraception throughout the study and for at least 90 days after
last dose

- Signed and dated informed consent

Exclusion Criteria:

- Monoclonal antibody based anti-cancer therapy within 28 days prior to study entry or
small-molecule based anti-cancer therapy (targeted therapy or chemotherapy) within 14
days prior to study entry. Combination F:PD-1/PD-L1 agent within 14 days prior study
entry.

- Current or prior use of immunosuppressive medication within 7 days prior to study
entry

- Active autoimmune disease requiring systemic steroids or immunosuppressive agents
within 7 days prior to study entry

- Known prior or suspected hypersensitivity to investigational products

- Major surgery within 4 weeks or radiation therapy within 14 days prior to study entry

- Patients with known symptomatic brain metastases requiring steroids

- Previous high-dose chemotherapy requiring stem cell rescue

- Prior allogeneic stem cell transplant or organ graft

- Any of the following within 6 months prior to study entry: myocardial infarction,
uncontrolled angina, coronary/peripheral artery bypass graft, symptomatic congestive
heart failure, cerebrovascular accident, or transient ischemic attack

- Symptomatic pulmonary embolism within 6 months prior to study entry

- Known HIV or AIDS-related illness

- Active infection requiring systemic therapy

- Positive HBV or HCV test indicating acute or chronic infection

- Administration of a live vaccine within 4 weeks prior to study entry

- Diagnosis of other malignancy within 5 years, except for adequately treated basal cell
or squamous cell skin cancer, or carcinoma in situ of the breast or cervix, or
low-grade (Gleason ≤6) prostate cancer

- Participation in other studies involving investigational drug(s) within 4 weeks prior
to study entry and/or during study participation

- Persisting toxicity related to prior therapy >Grade 1

- Other severe acute or chronic medical condition

- Combo C :Existing periorbital edema.

- Combo C : Hypocalcemia, clinically significant bone disease or recent bone fracture
(within 12 weeks prior study entry)
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Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No