This is a multi-center, open-label, phase I/II clinical study to evaluate ICP-192 in patients with advanced solid tumors and FGFR gene alterations. It consists of two parts: Part I (Phase I), dose escalation and Part II (Phase II), dose expansion.
Part I (Phase I) of the study enrolls patients with advanced solid tumors (9-15 patients);
Part II (Phase II) of the study enrolls patients with urothelial carcinoma or
cholangiocarcinoma with FGFR genetic alterations (30 patients).
Overal Status | Start Date | Phase | Study Type |
---|---|---|---|
Recruiting | September 14, 2020 | Phase 1/Phase 2 | Interventional |
Primary Outcome 1 - Measure: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
Primary Outcome 1 - Time Frame: Up to 3 years
Primary Outcome 2 - Measure: MTD
Primary Outcome 2 - Time Frame: Up to 3 years
Primary Outcome 3 - Measure: OBD
Primary Outcome 3 - Time Frame: Up to 3 years
Primary Outcome 4 - Measure: RP2D
Primary Outcome 4 - Time Frame: Up to 3 years
Primary Outcome 5 - Measure: ORR
Primary Outcome 5 - Time Frame: Up to 3 years
Criteria:
Major Inclusion Criteria
Participants are eligible to be included in the study only if all of the following criteria
apply:
1. Participate voluntarily, sign informed consent, and follow the study treatment plan
and scheduled visits;
2. Phase I: Patients with histologically or cytologically confirmed unresectable or
metastatic advanced malignant solid tumors who have progressed under standard
treatment or recurred after or were intolerant to all standard treatment regimens, or
have no standard treatment available;
3. Phase II: patients with histologically or cytologically confirmed unresectable or
metastatic urothelial carcinoma or cholangiocarcinoma, who have progressed or recurred
after or were intolerant to first-line chemotherapy, or have progressed/relapsed
within 12 months after neoadjuvant /adjuvant chemotherapy;
4. Phase II: Existing test reports have confirmed the FGFR gene alteration or the central
laboratory has detected the FGFR gene alteration.
5. Age ≥18 years old;
6. At least one measurable lesion according to the Response Evaluation Criteria of Solid
Tumor, version 1.1 (RECIST 1.1);
7. ECOG performance status of 0-1;
8. Life expectancy for more than 3 months; Must have adequate organ function Major
Exclusion Criteria
Participants are excluded from the study if any of the following criteria apply:
1. Have previously been treated with selective pan-FGFR molecular inhibitors or antibody
drugs, except for the FGFR4 selective inhibitors;
2. Within 2 weeks before the first dose of study drug, the subject's phosphate level
continuing to exceed the ULN despite medical treatment;
3. Patients with clinically significant gastrointestinal dysfunction
4. Has known central nervous system metastases;
5. Has a history of or currently uncontrolled cardiovascular diseases
6. History of organ transplantation or a history of allogeneic hematopoietic stem cell
transplantation;
7. Current evidence of corneal or retinal abnormalities that may increase eye toxicity;
8. Active hepatitis B virus active hepatitis C, or HIV infection;
9. Has not recovered from reversible toxicity of prior anti-tumor therapy
10. Pregnant or lactating women, as well as women with childbearing potential who are
unwilling or unable to perform contraception from the screening to 6 months after the
last study drug administration; and fertile men who are unwilling or unable to perform
contraception from screening to 3months after the last study drug administration
11. Other conditions considered by the investigator to be inappropriate for participation
in this study.
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
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Gender: All
Minimum Age: 18 Years
Maximum Age: N/A
Healthy Volunteers: No
Name: Olivia Yang
Phone: +1 (609) 524-0684
Email: olivia.yang@INNOCAREPHARMA.COM
Facility | Status | Contact |
---|---|---|
Mid Florida Hematology and Oncology Orange City, Florida 32763 United States |
Recruiting |
Santosh Nash, MD |