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BRIEF TITLE: Eribulin (NSC #707389) With or Without Gemcitabine Versus Standard of Care (Physician's Choice) for Treatment of Metastatic Urothelial Carcinoma Refractory to, or Ineligible for, Anti PD1/PDL1 Therapy

A Phase III Randomized Trial of Eribulin (NSC #707389) With or Without Gemcitabine Versus Standard of Care (Physician's Choice) for Treatment of Metastatic Urothelial Carcinoma Refractory to, or Ineligible for, Anti PD1/PDL1 Therapy


  • Org Study ID: NCI-2020-07651
  • Secondary ID: NCI-2020-07651,S1937,S1937,U10CA180888
  • NCT ID: NCT04579224
  • NCT Alias:
  • Sponsor: National Cancer Institute (NCI) - NIH
  • Source: National Cancer Institute (NCI)

Brief Summary

This phase III trial compares the usual chemotherapy treatment to eribulin alone and to eribulin plus gemcitabine in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as eribulin, gemcitabine, docetaxel, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial aims to see whether adding eribulin to standard of care chemotherapy may work better in treating patients with metastatic urothelial cancer.

Detailed Description


PRIMARY OBJECTIVES:

I. To compare overall survival (OS) in participants with metastatic urothelial carcinoma
(mUC) who are randomized to standard treatment versus eribulin mesylate (eribulin) alone.

II. To compare overall survival in participants with metastatic urothelial carcinoma (mUC)
who are randomized to standard treatment versus eribulin plus gemcitabine hydrochloride
(gemcitabine).

III. To compare overall survival in participants with metastatic urothelial carcinoma (mUC)
who are randomized to eribulin alone versus eribulin plus gemcitabine.

SECONDARY OBJECTIVES:

I. To compare progression-free survival (PFS) in the standard treatment arm to the two
experimental treatment arms in this population.

II. To compare Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 overall response
rate (ORR), both confirmed and unconfirmed, complete and partial responses (CR and PR), in
the standard treatment arm to the two experimental treatment arms in the subset of
participants with measurable disease in this population.

III. To compare duration of response (DOR) in the standard treatment arm to the two
experimental treatment arms in the subset of participants with measurable disease in this
population.

IV. To compare disease control rate (DCR) in the standard treatment arm to the two
experimental treatment arms in the subset of participants with measurable disease in this
population.

BANKING OBJECTIVE:

I. To bank specimens for future correlative studies.

OUTLINE: Patients are randomized to 1 of 3 arms.

ARM I: Patients receive 1 of the 3 standard of care chemotherapy regimens based on treating
investigator's choice: Choice A: Patients receive docetaxel intravenously (IV) on day 1.
Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Choice B: Patients receive gemcitabine IV on days 1, 8, and 15. Cycles repeat every 28 days
in the absence of disease progression or unacceptable toxicity. Choice C: Patients receive
paclitaxel IV on days 1, 8, and 15. Cycles repeat every 21 days in the absence of disease
progression or unacceptable toxicity.

ARM II: Patients receive eribulin IV over 2-5 minutes on days 1 and 8. Cycles repeat every 21
days in the absence of disease progression or unacceptable toxicity.

ARM III: Patients receive eribulin IV over 2-5 minutes and gemcitabine IV on days 1 and 8.
Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 6 months for 2 years from
the date of registration, then every 12 months until death or 3 years from the date of
registration

Overal Status Start Date Phase Study Type
Recruiting February 16, 2021 Phase 3 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: Overall survival

Primary Outcome 1 - Time Frame: From date of registration to date of death due to any cause, assessed up to 3 years

Condition:

  • Metastatic Bladder Urothelial Carcinoma
  • Metastatic Renal Pelvis Urothelial Carcinoma
  • Metastatic Ureter Urothelial Carcinoma
  • Metastatic Urethral Urothelial Carcinoma
  • Metastatic Urothelial Carcinoma
  • Refractory Bladder Urothelial Carcinoma
  • Refractory Renal Pelvis Urothelial Carcinoma
  • Refractory Ureter Urothelial Carcinoma
  • Refractory Urethral Urothelial Carcinoma
  • Refractory Urothelial Carcinoma
  • Stage IV Bladder Cancer AJCC v8
  • Stage IV Renal Pelvis and Ureter Cancer AJCC v8
  • Stage IV Renal Pelvis Cancer AJCC v8
  • Stage IV Ureter Cancer AJCC v8
  • Stage IV Urethral Cancer AJCC v8
  • Stage IVA Bladder Cancer AJCC v8
  • Stage IVB Bladder Cancer AJCC v8

Eligibility

Criteria:
Inclusion Criteria:

- Participant must have predominant histologically and cytologically proven urothelial
carcinoma in a metastatic site

- Participant must have evidence of metastatic urothelial carcinoma based on computed
tomography (CT) or magnetic resonance imaging (MRI) within 28 days prior to
registration

- Participant must have had progression of disease following prior therapy at the
discretion of the treating investigator

- Participant must have received previous systemic treatment for metastatic urothelial
carcinoma with either a platinum-based chemotherapy regimen, systemic PD1/PDL1
immunotherapy, an antibody drug conjugate such as, enfortumab vedotin or sacituzumab
govitecan (through standard of care or a clinical trial). There is no limit to the
number of prior regimens patient may have received for urothelial carcinoma

- If participant is a candidate for a platinum-based chemotherapy, then participant
must have previously received a platinum-based chemotherapy

- If participant is a candidate for immunotherapy, then participant must have
previously received immunotherapy. If participant is not a candidate for
immunotherapy, then participant either: (a) must have had prior anti PD1/PDL1
antibody therapy; OR (b) must have not been a candidate for anti PD1/PDL1
antibody therapy in the opinion of the treating physician

- Participant is eligible if platinum based chemotherapy and/or anti PDL/PDL1
antibody therapy was provided in perioperative setting before or after radical
cystectomy and if there is evidence of progression to metastatic disease within
12 months of the last dose of therapy. For instance, a patient treated with
dose-dense combination of methotrexate, vinblastine, doxorubicin, and cisplatin
(ddMVAC) in neoadjuvant setting, then radical cystectomy followed by adjuvant
pembrolizumab on AMBASSADOR trial will meet the requirement for prior/concurrent
therapy if progression of disease occurs within 12 months of discontinuation of
pembrolizumab

- Participant must have received any planned surgery prior to registration

- Participant must have Zubrod performance status 0-2

- Participant must have history and physical examination within 28 days prior to
registration

- Participant must have complete blood count (CBC), complete metabolic panel including
liver function tests, and lactate dehydrogenase (LDH) obtained with 28 days prior to
registration

- Participant must have adequate kidney function as evidenced by measured or calculated
creatinine clearance >= 50 mL/min within 28 days prior to registration

- Participant must have adequate hepatic function documented by either aspartate
aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x institutional upper
limit of normal (IULN) within 28 days prior to registration. If both AST and ALT are
performed, both must be =< 3 x IULN. For participants with liver metastases, AST or
ALT must be =< 5 x IULN

- Participant must be on effective anti-retroviral therapy and have undetectable viral
load at their most recent viral load test and within 6 months prior to registration if
they are known to have human immunodeficiency virus (HIV)-infection

- Participants must have undetectable hepatitis B virus (HBV) viral load within 28 days
prior to registration if participant has known chronic hepatitis B virus (HBV)
infection

- Participants with a known history of hepatitis C virus (HCV) infection must have an
undetectable HCV viral load within 28 days prior to registration

- Participants may have a prior or concurrent malignancy provided the natural history or
treatment does not have the potential to interfere with the safety or efficacy
assessment of the investigational regimen per the opinion of the treating investigator

- Participants must be informed of the investigational nature of this study and must
sign and give written informed consent in accordance with institutional and federal
guidelines

Exclusion Criteria:

- Participants must not require immediate central nervous system (CNS)-specific
treatment, in the opinion of the treating investigator if they have active brain
metastases (defined as new or progressive brain metastases) or leptomeningeal disease

- Participant must not have progressed within 3 months following last dose of
gemcitabine

- Participant must not have unresolved toxicities from prior surgeries or radiation
therapy > grade 1 at the time of registration to registration

- Participants must not be planning to take strong or moderate CYP3A or CYP2C8
inhibitors or inducers if randomized to Arm 1 and standard of care (SOC) regimen
chosen is paclitaxel or docetaxel. Participants receiving strong or moderate CYP3A or
CYP2C8 inducers must discontinue use at least 2 weeks prior to randomization

- Participant must not have a known history of corrected QT (QTc) prolongation

- Participants must not be pregnant or nursing due to the risk of harm to a fetus or
nursing infant. Women and men of reproductive potential must have agreed to use an
effective contraceptive method for the course of the study and 6 months (females) or
3.5 months (males) after the last dose. A woman is considered to be of reproductive
potential" if she has had menses at any time in the preceding 12 consecutive months.
In addition to routine contraceptive methods, "effective contraception" also includes
heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect
of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or
bilateral tubal ligation. However, if at any point a previously celibate participant
chooses to become heterosexually active during the time period for use of
contraceptive measures outlined in the protocol, he/she is responsible for beginning
contraceptive measures
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Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Sarmad Sadeghi

Role: Principal Investigator

Affiliation: Southwest Oncology Group

Locations

Facility Status Contact
Kingman Regional Medical Center
Kingman, Arizona 86401
United States
Recruiting Site Public Contact

protocols@swog.org
PCR Oncology
Arroyo Grande, California 93420
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Los Angeles County-USC Medical Center
Los Angeles, California 90033
United States
Recruiting Site Public Contact
323-865-0451
USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
United States
Recruiting Site Public Contact
323-865-0451
USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California 92663
United States
Recruiting Site Public Contact
323-865-0451
Keck Medical Center of USC Pasadena
Pasadena, California 91105
United States
Recruiting Site Public Contact
323-865-0451
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida 33180
United States
Recruiting Site Public Contact
305-674-2625
yenrique@msmc.com
Holy Cross Hospital
Fort Lauderdale, Florida 33308
United States
Recruiting Site Public Contact
954-267-7750
Mount Sinai Medical Center
Miami Beach, Florida 33140
United States
Recruiting Site Public Contact
305-674-2625
yenrique@msmc.com
Rush - Copley Medical Center
Aurora, Illinois 60504
United States
Recruiting Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
United States
Recruiting Site Public Contact
618-457-5200
clinical.research@sih.net
SIH Cancer Institute
Carterville, Illinois 62918
United States
Recruiting Site Public Contact
618-985-3333
clinical.research@sih.net
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Carle on Vermilion
Danville, Illinois 61832
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Recruiting Site Public Contact
815-285-7800
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United States
Recruiting Site Public Contact
309-344-2831
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
United States
Recruiting Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Peoria, Illinois 61636
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Valley Radiation Oncology
Peru, Illinois 61354
United States
Recruiting Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Recruiting Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
United States
Recruiting Site Public Contact
800-444-7541
Memorial Medical Center
Springfield, Illinois 62781
United States
Recruiting Site Public Contact
217-788-3528
Carle Cancer Center
Urbana, Illinois 61801
United States
Recruiting Site Public Contact
800-446-5532
Research@carle.com
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
United States
Recruiting Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com
Mary Greeley Medical Center
Ames, Iowa 50010
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC - Ames
Ames, Iowa 50010
United States
Recruiting Site Public Contact
515-239-4734
ksoder@mcfarlandclinic.com
McFarland Clinic PC-Boone
Boone, Iowa 50036
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC-Jefferson
Jefferson, Iowa 50129
United States
Recruiting Site Public Contact
515-956-4132
McFarland Clinic PC-Marshalltown
Marshalltown, Iowa 50158
United States
Recruiting Site Public Contact
515-956-4132
Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Ascension Saint John Hospital
Detroit, Michigan 48236
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Hurley Medical Center
Flint, Michigan 48503
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan 48236
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Sparrow Hospital
Lansing, Michigan 48912
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Hope Cancer Center
Pontiac, Michigan 48341
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Oakland
Pontiac, Michigan 48341
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Ascension Saint Mary's Hospital
Saginaw, Michigan 48601
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Macomb Hematology Oncology PC
Warren, Michigan 48093
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Recruiting Site Public Contact
218-333-5000
OncologyClinicalTrialsFargo@sanfordhealth.org
Fairview Ridges Hospital
Burnsville, Minnesota 55337
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Minnesota Oncology - Burnsville
Burnsville, Minnesota 55337
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Cambridge Medical Center
Cambridge, Minnesota 55008
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Unity Hospital
Fridley, Minnesota 55432
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Health Partners Inc
Minneapolis, Minnesota 55454
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Monticello Cancer Center
Monticello, Minnesota 55362
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
New Ulm Medical Center
New Ulm, Minnesota 56073
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Northland Medical Center
Princeton, Minnesota 55371
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Regions Hospital
Saint Paul, Minnesota 55101
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
United Hospital
Saint Paul, Minnesota 55102
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Lakeview Hospital
Stillwater, Minnesota 55082
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota 56701
United States
Recruiting Site Public Contact
605-312-3320
Ridgeview Medical Center
Waconia, Minnesota 55387
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Rice Memorial Hospital
Willmar, Minnesota 56201
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Sanford Cancer Center Worthington
Worthington, Minnesota 56187
United States
Recruiting Site Public Contact
605-312-3320
Fairview Lakes Medical Center
Wyoming, Minnesota 55092
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Recruiting Site Public Contact
573-334-2230
sfmc@sfmc.net
Southeast Cancer Center
Cape Girardeau, Missouri 63703
United States
Recruiting Site Public Contact
573-651-5550
Parkland Health Center - Farmington
Farmington, Missouri 63640
United States
Recruiting Site Public Contact
314-996-5569
Capital Region Southwest Campus
Jefferson City, Missouri 65109
United States
Recruiting Site Public Contact
573-632-4814
swooden@mail.crmc.org
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
United States
Recruiting Site Public Contact
314-996-5569
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Recruiting Site Public Contact
314-996-5569
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
Recruiting Site Public Contact
314-996-5569
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri 63127
United States
Recruiting Site Public Contact
314-996-5569
Carson Tahoe Regional Medical Center
Carson City, Nevada 89703
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Cancer and Blood Specialists-Henderson
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Cancer Center-Henderson
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
OptumCare Cancer Care at Seven Hills
Henderson, Nevada 89052
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
21st Century Oncology-Henderson
Henderson, Nevada 89074
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada 89074
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Urology - Green Valley
Henderson, Nevada 89074
United States
Recruiting Site Public Contact

research@sncrf.org
Las Vegas Urology - Pebble
Henderson, Nevada 89074
United States
Recruiting Site Public Contact

research@sncrf.org
Urology Specialists of Nevada - Green Valley
Henderson, Nevada 89074
United States
Recruiting Site Public Contact

research@sncrf.org
Las Vegas Urology - Pecos
Las Vegas, Nevada 89074
United States
Recruiting Site Public Contact

research@sncrf.org
Desert West Surgery
Las Vegas, Nevada 89102
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
University Medical Center of Southern Nevada
Las Vegas, Nevada 89102
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Hope Cancer Care of Nevada
Las Vegas, Nevada 89103
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada 89106
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Urology Specialists of Nevada - Central
Las Vegas, Nevada 89106
United States
Recruiting Site Public Contact

research@sncrf.org
21st Century Oncology
Las Vegas, Nevada 89109
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Sunrise Hospital and Medical Center
Las Vegas, Nevada 89109
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Prostate Cancer Center
Las Vegas, Nevada 89113
United States
Recruiting Site Public Contact

research@sncrf.org
Las Vegas Urology - Sunset
Las Vegas, Nevada 89113
United States
Recruiting Site Public Contact

research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada 89119
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
21st Century Oncology-Vegas Tenaya
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Ann M Wierman MD LTD
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Urology - Cathedral Rock
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact

research@sncrf.org
Las Vegas Urology - Smoke Ranch
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact

research@smcrf.org
OptumCare Cancer Care at MountainView
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Urology Specialists of Nevada - Northwest
Las Vegas, Nevada 89128
United States
Recruiting Site Public Contact

research@sncrf.org
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada 89135
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada 89144
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada 89144
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Summerlin Hospital Medical Center
Las Vegas, Nevada 89144
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada 89148-2405
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
21st Century Oncology-Fort Apache
Las Vegas, Nevada 89148
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89148
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Urology Specialists of Nevada - Southwest
Las Vegas, Nevada 89148
United States
Recruiting Site Public Contact

research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada 89169
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
University Cancer Center
Las Vegas, Nevada 89169
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada 89048
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Renown Regional Medical Center
Reno, Nevada 89502
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Saint Mary's Regional Medical Center
Reno, Nevada 89503
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Radiation Oncology Associates
Reno, Nevada 89509
United States
Recruiting Site Public Contact
702-384-0013
research@sncrf.org
Glens Falls Hospital
Glens Falls, New York 12801
United States
Recruiting Site Public Contact
518-926-6700
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Recruiting Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford South University Medical Center
Fargo, North Dakota 58103
United States
Recruiting Site Public Contact
701-234-6161
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota 58103
United States
Recruiting Site Public Contact
605-312-3320
Sanford Medical Center Fargo
Fargo, North Dakota 58104
United States
Recruiting Site Public Contact
800-437-4010
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Recruiting Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Recruiting Site Public Contact
701-234-6161
OncologyClinicalTrialsFargo@sanfordhealth.org
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania 18017
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania 18201
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Recruiting Site Public Contact
605-312-3320
OncologyClinicTrialsSF@sanfordhealth.org
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Recruiting Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org
Wellmont Bristol Regional Medical Center
Bristol, Tennessee 37620
United States
Recruiting Site Public Contact
423-578-8538
justin.reynolds@wellmont.org
Regional Cancer Center at Indian Path Community Hospital
Kingsport, Tennessee 37660
United States
Recruiting Site Public Contact
423-578-8538
Justin.reynolds@balladhealth.org
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee 37660
United States
Recruiting Site Public Contact
423-578-8538
justin.reynolds@wellmont.org
Wellmont Medical Associates-Bristol
Bristol, Virginia 24201
United States
Recruiting Site Public Contact
423-578-8538
justin.reynolds@wellmont.org
Southwest VA Regional Cancer Center
Norton, Virginia 24273
United States
Recruiting Site Public Contact
423-578-8538
justin.reynolds@wellmont.org
Overlake Medical Center
Bellevue, Washington 98004
United States
Recruiting Site Public Contact
425-688-5407
OHMCResearch@overlakehospital.org
Valley Medical Center
Renton, Washington 98055
United States
Recruiting Site Public Contact
425-228-3440
research@valleymed.org
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com