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BRIEF TITLE: Study of Cystectomy Plus Perioperative Pembrolizumab Versus Cystectomy Alone in Cisplatin-ineligible Participants With Muscle-invasive Bladder Cancer (KEYNOTE-905)

A Randomized Phase 3 Study Evaluating Cystectomy With Perioperative Pembrolizumab and Cystectomy With Perioperative Enfortumab Vedotin and Pembrolizumab Versus Cystectomy Alone in Cisplatin-Ineligible Participants With Muscle-Invasive Bladder Cancer (KEYNOTE-905/EV-303)


  • Org Study ID: 3475-905
  • Secondary ID: MK-3475-905,2018-003809-26,KEYNOTE-905,EV-303
  • NCT ID: NCT03924895
  • NCT Alias:
  • Sponsor: Merck Sharp & Dohme Corp. - Industry
  • Source: Merck Sharp & Dohme Corp.

Brief Summary

A global, randomized phase III study to evaluate perioperative pembrolizumab with radical cystectomy + pelvic lymph node dissection (RC+PLND) versus RC+PLND alone in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC).

Overal Status Start Date Phase Study Type
Recruiting July 24, 2019 Phase 3 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: Pathologic Complete Response (pCR) Rate in All Participants

Primary Outcome 1 - Time Frame: Up to approximately 3 months (Time of surgery)

Primary Outcome 2 - Measure: Pathologic Complete Response Rate in Participants Whose Tumors Express PD-L1 Combined Positive Score (CPS) ≥10

Primary Outcome 2 - Time Frame: Up to approximately 3 months (Time of surgery)

Primary Outcome 3 - Measure: Event-Free Survival (EFS) in All Participants

Primary Outcome 3 - Time Frame: Up to approximately 5.5 years

Primary Outcome 4 - Measure: Event-Free Survival in Participants Whose Tumors Express PD-L1, CPS ≥10

Primary Outcome 4 - Time Frame: Up to approximately 5.5 years

Condition:

  • Urinary Bladder Cancer, Muscle-invasive

Eligibility

Criteria:
Inclusion Criteria:

- Histologically confirmed diagnosis of muscle-invasive bladder cancer (MIBC)
cT2-T4aN0M0 or cT1-T4aN1M0 with predominant (≥50%) urothelial histology. Participants
with mixed histology are eligible provided the urothelial component is ≥50%.
Urothelial carcinomas not originating from the bladder are not eligible. Participants
whose tumors show any of the following variant histologies are not eligible:
plasmacytoid, clear cell, lipid rich, giant cell, sarcomatoid, and/or neuroendocrine
component.

- Clinically non-metastatic bladder cancer determined by imaging

- Eligible for radical cystectomy (RC) + pelvic lymph node dissection (PLND ), and
agreement to undergo curative intent standard RC + PLND (including prostatectomy if
applicable)

- Ineligible for treatment with cisplatin, as defined by meeting at least one of the
following criteria:

- Impaired renal function with measured or calculated CrCl 30 to 59 mL/min

- Eastern Cooperative Oncology Group (ECOG) Performance Status 2

- Common Terminology Criteria for Adverse Events (CTCAE) v.4 Grade ≥2 audiometric
hearing loss

- New York Heart Association (NYHA) Class III heart failure

- Transurethral resection (TUR) of a bladder tumor that is submitted and adequate to
determine determine pathologic stage pT2-T4a or pT1, urothelial histology, and PD-L1
status. For confirmation of stages T2-T4a, TUR biopsy samples must include detrusor
muscle.

- ECOG performance status of 0, 1, or 2

- Adequate organ function

Exclusion Criteria:

- Known additional non-urothelial malignancy that is progressing or has required active
treatment ≤3 years of study randomization, with certain exceptions

- ≥ N2 or M1 disease

- Received any prior systemic anti-neoplastic treatment for muscle-invasive bladder
cancer (MIBC)

- Received prior therapy with an anti-programmed cell death protein 1 (PD-1),
anti-programmed death-ligand 1 (PD-L1), or anti-programmed cell death 1 ligand 2
(PD-L2), or with an agent directed to another stimulatory or co-inhibitory T-cell
receptor

- Received prior systemic anti-cancer therapy including investigational agents within 3
years prior to randomization

- Received any prior radiotherapy to the bladder

- Received a partial cystectomy of the bladder to remove any non-muscle-invasive bladder
cancer (NMIBC) or MIBC

- Received a live vaccine within 30 days prior to the first dose of study drug

- Current participation in or participation in a study of an investigational agent or
use of an investigational device within 4 weeks prior to the first dose of study
intervention

- Ongoing sensor or motor neuropathy Grade 2 or higher

- Diagnosis of immunodeficiency or receipt of chronic systemic steroid therapy or any
other form of immunosuppressive therapy within 7 days prior the first dose of study
drug. Physiologic replacement doses of corticosteroids are permitted for participants
with adrenal insufficiency.

- Hypersensitivity to monoclonal antibodies (including pembrolizumab) and/or any of
their excipients

- Severe (≥ Grade 3) hypersensitivity to any enfortumab vedotin excipient contained in
the drug formulation of enfortumab vedotin

- Active keratitis or corneal ulcerations. Participants with superficial punctate
keratitis are allowed if the disorder is being adequately treated in the opinion of
the investigator.

- Active autoimmune disease that has required systemic therapy in past 2 years (i.e.,
with use of disease modifying agents, corticosteroids or immunosuppressive drugs).
Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency) is not considered a form
of systemic therapy and is allowed.

- History of uncontrolled diabetes

- History of (non-infectious) pneumonitis that required steroids, or current
pneumonitis.

- Active infection requiring systemic therapy

- Has had an allogenic tissue/solid organ transplant
Show More

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Medical Director

Role: Study Director

Affiliation: Merck Sharp & Dohme Corp.

Overall Contact

Name: Toll Free Number

Phone: 1-888-577-8839

Email: Trialsites@merck.com

Link: Merck Oncology Clinical Trials Information

Locations

Facility Status Contact
Scripps MD Anderson ( Site 0010)
La Jolla, California 92037
United States
Recruiting Study Coordinator
858-554-8367
John Wayne Cancer Institute ( Site 0075)
Santa Monica, California 90404
United States
Recruiting Study Coordinator
310-582-7456
Georgetown University Medical Center ( Site 0022)
Washington, District of Columbia 20007
United States
Recruiting Study Coordinator
202-444-2198
Emory University ( Site 0006)
Atlanta, Georgia 30322
United States
Recruiting Study Coordinator
404-778-4823
Parkview Cancer Institute ( Site 0077)
Fort Wayne, Indiana 46845
United States
Recruiting Study Coordinator
260-266-9167
Indiana University Melvin and Bren Simon Cancer Center ( Site 0004)
Indianapolis, Indiana 46202
United States
Recruiting Study Coordinator
317-274-7477
Wichita Urology Group ( Site 0059)
Wichita, Kansas 67226
United States
Recruiting Study Coordinator
316-636-6141
Greater Baltimore Medical Center ( Site 0014)
Baltimore, Maryland 21204
United States
Recruiting Study Coordinator
443-849-3285
Morristown Medical Center ( Site 0015)
Morristown, New Jersey 07962
United States
Recruiting Study Coordinator
973-971-5373
The University of New Mexico Comprehensive Cancer Center ( Site 0045)
Albuquerque, New Mexico 87131
United States
Recruiting Study Coordinator
505-925-0421
New York University Perlmutter Cancer Center ( Site 0008)
New York, New York 10016
United States
Recruiting Study Coordinator
212-731-5820
Icahn School of Medicine at Mount Sinai ( Site 0031)
New York, New York 10029
United States
Recruiting Study Coordinator
212-659-5452
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0021)
Tulsa, Oklahoma 74146
United States
Recruiting Study Coordinator
918-505-3200
Abramson Cancer Center of the University of Pennsylvania ( Site 0074)
Philadelphia, Pennsylvania 19104
United States
Recruiting Study Coordinator
215-614-1842
Fox Chase Cancer Center ( Site 0055)
Philadelphia, Pennsylvania 19111
United States
Recruiting Study Coordinator
215-728-1133
Allegheny General Hospital ( Site 0048)
Pittsburgh, Pennsylvania 15212
United States
Recruiting Study Coordinator
412-359-8373
Carolina Urologic Research Center ( Site 0062)
Myrtle Beach, South Carolina 29572
United States
Recruiting Study Coordinator
8434491010257
Urology Associates [Nashville, TN] ( Site 0053)
Nashville, Tennessee 37209
United States
Recruiting Study Coordinator
615-250-9268
Vanderbilt University Medical Center ( Site 0017)
Nashville, Tennessee 37232
United States
Recruiting Study Coordinator
615-936-5173
Inova Schar Cancer Institute ( Site 0007)
Fairfax, Virginia 22031
United States
Recruiting Study Coordinator
571-472-0623
Charleston Area Medical Center ( Site 0023)
Charleston, West Virginia 25304
United States
Recruiting Study Coordinator
304-388-9944
Western Sydney Local Health District ( Site 1259)
Blacktown, New South Wales 2148
Australia
Recruiting Study Coordinator
+61411462609
Macquarie University ( Site 1251)
Macquarie Park, New South Wales 2109
Australia
Recruiting Study Coordinator
+61298123500
Cairns Base Hospital ( Site 1257)
Cairns, Queensland 4870
Australia
Recruiting Study Coordinator
+61742268085
Mater Misericordiae Ltd ( Site 1258)
South Brisbane, Queensland 4101
Australia
Recruiting Study Coordinator
+61731769289
Eastern Health ( Site 1255)
Box Hill, Victoria 3128
Australia
Recruiting Study Coordinator
+61398953585
Monash Health ( Site 1260)
Clayton, Victoria 3168
Australia
Recruiting Study Coordinator
+61395086161
UCL Saint-Luc - Oncologie Medicale ( Site 0357)
Bruxelles, Bruxelles-Capitale, Region De 1200
Belgium
Recruiting Study Coordinator
+3227649457
CHU UCL Namur Site de Godinne ( Site 0354)
Yvoir, Namur 5530
Belgium
Recruiting Study Coordinator
+3281423858
AZ Maria Middelares Gent ( Site 0353)
Gent, Oost-Vlaanderen 9000
Belgium
Recruiting Study Coordinator
+3292469522
Tom Baker Cancer Centre ( Site 0100)
Calgary, Alberta T2N 4N2
Canada
Recruiting Study Coordinator
4034762543
Silverado Resarch Inc. ( Site 0111)
Victoria, British Columbia V8T 2C1
Canada
Recruiting Study Coordinator
2505929998
Moncton Hospital - Horizon Health Network ( Site 0112)
Moncton, New Brunswick E1C 6Z8
Canada
Recruiting Study Coordinator
5068575076
Sunnybrook Research Institute ( Site 0110)
Toronto, Ontario M4N 3M5
Canada
Recruiting Study Coordinator
416480500082139
Princess Margaret Cancer Centre ( Site 0107)
Toronto, Ontario M5G 2M9
Canada
Recruiting Study Coordinator
4169462246
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0105)
Montreal, Quebec H1T 2M4
Canada
Recruiting Study Coordinator
51425234005853
CIUSSS de l'Estrie-CHUS ( Site 0106)
Sherbrooke, Quebec J1H 5N4
Canada
Recruiting Study Coordinator
819346111012827
Herlev og Gentofte Hospital. ( Site 0412)
Herlev, Hovedstaden 2730
Denmark
Recruiting Study Coordinator
+4538683494
Rigshospitalet University Hospital ( Site 0411)
Kobenhavn, Hovedstaden 2100
Denmark
Recruiting Study Coordinator
+4535458403
Odense Universitetshospital ( Site 0413)
Odense, Syddanmark 5000
Denmark
Recruiting Study Coordinator
+4524998173
Centre Francois Baclesse ( Site 0459)
Caen, Calvados 14076
France
Recruiting Study Coordinator
+33231455002
Centre Georges Francois Leclerc ( Site 0488)
Dijon, Cote-d'Or 21000
France
Recruiting Study Coordinator
+33380293761
CHU Jean Minjoz ( Site 0455)
Besancon, Doubs 25000
France
Recruiting Study Coordinator
+33370632403
Institut de Cancerologie du Gard - CHU Caremeau ( Site 0490)
Nimes, Gard 30029
France
Recruiting Study Coordinator
+33466683301
Institut Claudius Regaud IUCT Oncopole ( Site 0486)
Toulouse, Haute-Garonne 31059
France
Recruiting Study Coordinator
+33531155993
CHU de Montpellier - Hopital Saint-Eloi ( Site 0469)
Montpellier, Herault 34295
France
Recruiting Study Coordinator
+33467332309
C.H.R.U. de Rennes. Hopital de Pontchaillou ( Site 0492)
Rennes, Ille-et-Vilaine 35033
France
Recruiting Study Coordinator
+33299284270
Hopital Belle Isle ( Site 0452)
Metz, Moselle 57045
France
Recruiting Study Coordinator
+0357841650
C.H.U. Lyon Sud ( Site 0466)
Pierre Benite, Rhone 69310
France
Recruiting Study Coordinator
+33478864324
Institut Gustave Roussy ( Site 0487)
Villejuif, Val-de-Marne 94805
France
Recruiting Study Coordinator
+33142115348
CHU Cochin ( Site 0475)
Paris, 75014
France
Recruiting Study Coordinator
+33158411439
Hopital Europeen Georges Pompidou ( Site 0476)
Paris, 75015
France
Recruiting Study Coordinator
+33156093447
Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0549)
Tuebingen, Baden-Wurttemberg 72076
Germany
Recruiting Study Coordinator
+4970712987235
Klinikum der Universitaet Muenchen - Grosshadern ( Site 0548)
Muenchen, Bayern 81377
Germany
Recruiting Study Coordinator
+498944000
Universitaetsklinikum Bonn ( Site 0550)
Bonn, Nordrhein-Westfalen 53127
Germany
Recruiting Study Coordinator
+4922828714184
Universitaetsklinikum Magdeburg A.o.R. ( Site 0535)
Magdeburg, Sachsen-Anhalt 39120
Germany
Recruiting Study Coordinator
+493916715034
Universitaetsklinikum Carl Gustav Carus ( Site 0532)
Dresden, Sachsen 01307
Germany
Recruiting Study Coordinator
+493514582447
Vivantes Klinikum am Urban ( Site 0529)
Berlin, 10967
Germany
Recruiting Study Coordinator
+4930130226301
SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 1010)
Szeged, Csongrad 6720
Hungary
Recruiting Study Coordinator
+3662545405
Petz Aladar Megyei Oktato Korhaz ( Site 1012)
Gyor, Gyor-Moson-Sopron 9023
Hungary
Recruiting Study Coordinator
+36203310075
Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 1001)
Budapest, 1106
Hungary
Recruiting Study Coordinator
+36703815172
Debreceni Egyetem Klinikai Kozpont ( Site 1006)
Debrecen, 4032
Hungary
Recruiting Study Coordinator
+3652255585
Tallaght University Hospital ( Site 0734)
Dublin, D24 NR0A
Ireland
Recruiting Study Coordinator
+35314144259
University Hospital Waterford ( Site 0747)
Waterford, X91 ER8E
Ireland
Recruiting Study Coordinator
+35351848934
Soroka Medical Center ( Site 0849)
Beer Sheva, HaDarom 8410101
Israel
Recruiting Study Coordinator
+972523514527
Meir Medical Center ( Site 0846)
Kfar Saba, HaMerkaz 4428164
Israel
Recruiting Study Coordinator
+97297471606
Rabin Medical Center ( Site 0847)
Petach Tikva, HaMerkaz 4941492
Israel
Recruiting Study Coordinator
+97239378074
Assaf Harofeh Medical Center ( Site 0848)
Zerifin, HaMerkaz 7030001
Israel
Recruiting Study Coordinator
+97289779715
Ha Emek Medical Center ( Site 0843)
Afula, HaTsafon 1834111
Israel
Recruiting Study Coordinator
+97246495723
Rambam Medical Center ( Site 0845)
Afula, HaTsafon 1834111
Israel
Recruiting Study Coordinator
+97247776750
Sheba Medical Center ( Site 0844)
Ramat Gan, Tell Abib 5265601
Israel
Recruiting Study Coordinator
+97235302191
Sourasky Medical Center ( Site 0850)
Tel Aviv, Tell Abib 6423906
Israel
Recruiting Study Coordinator
+97236973413
Shaare Zedek Medical Center ( Site 0842)
Jerusalem, Yerushalayim 9103102
Israel
Recruiting Study Coordinator
+97226666331
Hadassah Ein Kerem Medical Center ( Site 0841)
Jerusalem, Yerushalayim 9112001
Israel
Recruiting Study Coordinator
+972505172315
A.O.U. Policlinico Vittorio Emanuele - Presidio Gaspare Rodolico ( Site 0559)
Catania, 95123
Italy
Recruiting Study Coordinator
+390953781518
Istituto Nazionale Studio e Cura dei Tumori ( Site 0551)
Milano, 20133
Italy
Recruiting Study Coordinator
+390223902402
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori ( Site 0552)
Napoli, 80131
Italy
Recruiting Study Coordinator
+39815903637
Fondazione Salvatore Maugeri IRCCS ( Site 0554)
Pavia, 27100
Italy
Recruiting Study Coordinator
+390382592265
Policlinico Gemelli di Roma ( Site 0558)
Roma, 00168
Italy
Recruiting Study Coordinator
+390458128116
National Cancer Center ( Site 1354)
Goyang-si, Kyonggi-do 10408
Korea, Republic of
Recruiting Study Coordinator
+82319201678
Seoul National University Bundang Hospital ( Site 1356)
Seongnam-si, Kyonggi-do 13620
Korea, Republic of
Recruiting Study Coordinator
+82317877351
Korea University Anam Hospital ( Site 1351)
Seoul, Seoul-teukbyeolsi [Seoul] 02841
Korea, Republic of
Recruiting Study Coordinator
+821099288097
Seoul National University Hospital ( Site 1352)
Seoul, Seoul-teukbyeolsi [Seoul] 03080
Korea, Republic of
Recruiting Study Coordinator
+82220720361
Asan Medical Center ( Site 1355)
Seoul, Seoul-teukbyeolsi [Seoul] 05505
Korea, Republic of
Recruiting Study Coordinator
+82230103980
Samsung Medical Center ( Site 1353)
Seoul, Seoul-teukbyeolsi [Seoul] 06351
Korea, Republic of
Recruiting Study Coordinator
+82234103557
Centro de Urologia Avanzada del Noreste S.A. de C.V. ( Site 0253)
Monterrey, Nuevo Leon 66269
Mexico
Recruiting Study Coordinator
+528180267452
Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. ( Site 0300)
Aguascalientes, 20010
Mexico
Recruiting Study Coordinator
+524494735100
Centro Estatal de Cancerologia de Chihuahua ( Site 0254)
Chihuahua, 31000
Mexico
Recruiting Study Coordinator
+526141420241
Instituto Nacional de Cancerologia. ( Site 0256)
Ciudad de Mexico, 14080
Mexico
Recruiting Study Coordinator
+5215514514014
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 1063)
Wroclaw, Dolnoslaskie 50-556
Poland
Recruiting Study Coordinator
+48601143281
Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 1068)
Bydgoszcz, Kujawsko-pomorskie 85-796
Poland
Recruiting Study Coordinator
+48605680944
Szpital Wojewodzki ( Site 1062)
Tarnow, Malopolskie 33-100
Poland
Recruiting Study Coordinator
+48602280826
Europejskie Centrum Zdrowia Otwock ( Site 1058)
Otwock, Mazowieckie 05-400
Poland
Recruiting Study Coordinator
+48227103025
Magodent Szpital Elblaska ( Site 1051)
Warszawa, Mazowieckie 01-748
Poland
Recruiting Study Coordinator
+48224308700
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku ( Site 1057)
Slupsk, Pomorskie 76-200
Poland
Recruiting Study Coordinator
+48598460705
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1061)
Bielsko-Biala, Slaskie 43-300
Poland
Recruiting Study Coordinator
+48606399091
Ivanovo Regional Oncology Dispensary ( Site 0852)
Ivanovo, Ivanovskaya Oblast' 153040
Russian Federation
Recruiting Study Coordinator
+79106672833
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0861)
Krasnoyarsk, Krasnoyarskiy Kray 660133
Russian Federation
Recruiting Study Coordinator
+79135349316
Kursk Regional Clinical Oncology Dispensary ( Site 0854)
Kursk, Kurskaya Oblast' 305524
Russian Federation
Recruiting Study Coordinator
+79103113475
Central Clinical Hospital with outpatient Clinic ( Site 0856)
Moscow, Moskva 121359
Russian Federation
Recruiting Study Coordinator
+79031691379
Bayandin Murmansk Regional Clinical Hospital ( Site 0859)
Murmansk, Murmanskaya Oblast' 183057
Russian Federation
Recruiting Study Coordinator
+79217252994
Volga District Medical Center Federal Medical and Biological Agency ( Site 0857)
Nizhny Novgorod, Nizhegorodskaya Oblast' 603074
Russian Federation
Recruiting Study Coordinator
+78314216977
Omsk Clinical Oncology Dispensary ( Site 0865)
Omsk, Omskaya Oblast 644013
Russian Federation
Recruiting Study Coordinator
+79139885114
Leningrad Regional Oncology Center ( Site 0868)
Saint Petersburg, Sankt-Peterburg 188663
Russian Federation
Recruiting Study Coordinator
+79219410363
Clinical Hospital Saint Luka ( Site 0867)
St. Petersburg, Sankt-Peterburg 194044
Russian Federation
Recruiting Study Coordinator
+79817217460
Saratov State Medical University n.a. V.I.Razumovskiy ( Site 0866)
Saratov, Saratovskaya Oblast' 410012
Russian Federation
Recruiting Study Coordinator
+79271233801
Hospital del Mar ( Site 0698)
Barcelona, Barcelona [Barcelona] 08003
Spain
Recruiting Study Coordinator
+34932483139
Hospital Universitario de Girona Doctor Josep Trueta ( Site 0700)
Girona, Girona [Gerona] 17007
Spain
Recruiting Study Coordinator
+349722258284028
Hospital Universitario Quiron Madrid ( Site 0694)
Pozuelo de Alarcon, Madrid 28223
Spain
Recruiting Study Coordinator
+34914521987
Instituto Valenciano de Oncologia - IVO ( Site 0679)
Valencia, Valenciana, Comunitat 46009
Spain
Recruiting Study Coordinator
+34961114605
Hospital San Pedro de Alcantara ( Site 0697)
Caceres, 10003
Spain
Recruiting Study Coordinator
+34927256200
Hospital Universitario Ramon y Cajal ( Site 0691)
Madrid, 28034
Spain
Recruiting Study Coordinator
+34913368263
Hospital Universitario San Carlos ( Site 0678)
Madrid, 28040
Spain
Recruiting Study Coordinator
+34913303000ext7554
Hospital Universitario la Paz ( Site 0690)
Madrid, 28046
Spain
Recruiting Study Coordinator
+34912071138
Hospital de Nuestra Senora de Valme ( Site 0693)
Sevilla, 41014
Spain
Recruiting Study Coordinator
+34955015000
Onkologiska kliniken ( Site 1212)
Solna, Stockholms Lan [se-01] 171 64
Sweden
Recruiting Study Coordinator
+4646768936655
Akademiska Sjukhuset ( Site 1211)
Uppsala, Uppsala Lan [se-03] 751 85
Sweden
Recruiting Study Coordinator
+46186110000
Cancercentrum ( Site 1214)
Umea, Vasterbottens Lan [se-24] 901 89
Sweden
Recruiting Study Coordinator
+46907853296
Ramathibodi Hospital. ( Site 1451)
Bangkok, Krung Thep Maha Nakhon 10400
Thailand
Recruiting Study Coordinator
+6622011671
Faculty of Medicine Siriraj Hospital ( Site 1452)
Bangkok, Krung Thep Maha Nakhon 10700
Thailand
Recruiting Study Coordinator
+6624194488
Maharaj Nakorn Chiangmai Hospital ( Site 1453)
Chiang Mai, 50200
Thailand
Recruiting Study Coordinator
+66539455324
Hacettepe Universitesi Tıp Fakultesi ( Site 0931)
Ankara, 06100
Turkey
Recruiting Study Coordinator
+905327233093
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0930)
Istanbul, 34096
Turkey
Recruiting Study Coordinator
+905324167355
Medeniyet Universitesi Goztepe Egitim ve Arastirma Hastanesi ( Site 0926)
Istanbul, 34722
Turkey
Recruiting Study Coordinator
+905323430723
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0921)
Istanbul, 34899
Turkey
Recruiting Study Coordinator
+905333832234
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0929)
Konya, 42080
Turkey
Recruiting Study Coordinator
+905334150753
Sakarya Universitesi Tip Fakultesi ( Site 0933)
Sakarya, 54290
Turkey
Recruiting Study Coordinator
+905054785576
Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi ( Site 0924)
Trabzon, 61080
Turkey
Recruiting Study Coordinator
+905052292035
Cherkasy Regional Oncology Dispensary ( Site 0959)
Cherkasy, Cherkaska Oblast 18009
Ukraine
Recruiting Study Coordinator
+380501606360
MI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 0963)
Dnipropetrovsk, Dnipropetrovska Oblast 49005
Ukraine
Recruiting Study Coordinator
+380567134785
Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC ( Site 0951)
Dnipro, Dnipropetrovska Oblast 49102
Ukraine
Recruiting Study Coordinator
+380675625054
Regional Oncology Center of Kharkiv ( Site 0958)
Kharkiv, Kharkivska Oblast 61000
Ukraine
Recruiting Study Coordinator
+380508266088
Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 0969)
Kharkiv, Kharkivska Oblast 61037
Ukraine
Recruiting Study Coordinator
+380577387134
National Cancer Institute of the MoH of Ukraine ( Site 0962)
Kyiv, Kyivska Oblast 03022
Ukraine
Recruiting Study Coordinator
+380672365175
Kyiv City Clinical Oncology Center ( Site 0960)
Kyiv, Kyivska Oblast 03115
Ukraine
Recruiting Study Coordinator
+380667027558
Lviv Regional Clinical Hospital ( Site 0955)
Lviv, Lvivska Oblast 79000
Ukraine
Recruiting Study Coordinator
+380677280861
Lviv State Regional Oncological Center ( Site 0967)
Lviv, Lvivska Oblast 79031
Ukraine
Recruiting Study Coordinator
+380973317578
Western General Hospital ( Site 0749)
Edinburgh, Edinburgh, City Of EH4 2XU
United Kingdom
Recruiting Study Coordinator
+441315372211
Kent and Canterbury Hospital ( Site 0733)
Canterbury, Kent CT1 3NG
United Kingdom
Recruiting Study Coordinator
+441227766877
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 0725)
London, London, City Of EC1A 7BE
United Kingdom
Recruiting Study Coordinator
+442078828505
Imperial College Healthcare NHS Trust ( Site 0745)
London, London, City Of W6 8RF
United Kingdom
Recruiting Study Coordinator
+442033117627
Royal Cornwall Hospital ( Site 0727)
Truro, TR1 3LJ
United Kingdom
Recruiting Study Coordinator
4418722500