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BRIEF TITLE: Study of Cystectomy Plus Perioperative Pembrolizumab Versus Cystectomy Alone in Cisplatin-ineligible Participants With Muscle-invasive Bladder Cancer (KEYNOTE-905)

A Randomized Phase 3 Study Evaluating Cystectomy With Perioperative Pembrolizumab and Cystectomy With Perioperative Enfortumab Vedotin and Pembrolizumab Versus Cystectomy Alone in Cisplatin-Ineligible Participants With Muscle-Invasive Bladder Cancer (KEYNOTE-905/EV-303)


  • Org Study ID: 3475-905
  • Secondary ID: MK-3475-905,2018-003809-26,KEYNOTE-905,EV-303
  • NCT ID: NCT03924895
  • NCT Alias:
  • Sponsor: Merck Sharp & Dohme Corp. - Industry
  • Source: Merck Sharp & Dohme Corp.

Brief Summary

A global, randomized phase III study to evaluate perioperative pembrolizumab with radical cystectomy + pelvic lymph node dissection (RC+PLND) versus RC+PLND alone in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC).

Overal Status Start Date Phase Study Type
Recruiting July 24, 2019 Phase 3 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: Pathologic Complete Response (pCR) Rate in All Participants

Primary Outcome 1 - Time Frame: Up to approximately 3 months (Time of surgery)

Primary Outcome 2 - Measure: Pathologic Complete Response Rate in Participants Whose Tumors Express PD-L1 Combined Positive Score (CPS) ≥10

Primary Outcome 2 - Time Frame: Up to approximately 3 months (Time of surgery)

Primary Outcome 3 - Measure: Event-Free Survival (EFS) in All Participants

Primary Outcome 3 - Time Frame: Up to approximately 5.5 years

Primary Outcome 4 - Measure: Event-Free Survival in Participants Whose Tumors Express PD-L1, CPS ≥10

Primary Outcome 4 - Time Frame: Up to approximately 5.5 years

Condition:

  • Urinary Bladder Cancer, Muscle-invasive

Eligibility

Criteria:
Inclusion Criteria:

- Histologically confirmed diagnosis of muscle-invasive bladder cancer (MIBC)
cT2-T4aN0M0 or cT1-T4aN1M0 with predominant (≥50%) urothelial histology. Participants
with mixed histology are eligible provided the urothelial component is ≥50%.
Urothelial carcinomas not originating from the bladder are not eligible. Participants
whose tumors show any of the following variant histologies are not eligible:
plasmacytoid, clear cell, lipid rich, giant cell, sarcomatoid, and/or neuroendocrine
component.

- Clinically non-metastatic bladder cancer determined by imaging

- Eligible for radical cystectomy (RC) + pelvic lymph node dissection (PLND ), and
agreement to undergo curative intent standard RC + PLND (including prostatectomy if
applicable)

- Ineligible for treatment with cisplatin, as defined by meeting at least one of the
following criteria:

- Impaired renal function with measured or calculated CrCl 30 to 59 mL/min

- Eastern Cooperative Oncology Group (ECOG) Performance Status 2

- Common Terminology Criteria for Adverse Events (CTCAE) v.4 Grade ≥2 audiometric
hearing loss

- New York Heart Association (NYHA) Class III heart failure

- Transurethral resection (TUR) of a bladder tumor that is submitted and adequate to
determine determine pathologic stage pT2-T4a or pT1, urothelial histology, and PD-L1
status. For confirmation of stages T2-T4a, TUR biopsy samples must include detrusor
muscle.

- ECOG performance status of 0, 1, or 2

- Adequate organ function

- A male participant is eligible to participate if he agrees to use contraception and
refrain from donating sperm during the intervention period and for at least 120 days
after the last dose of enfortumab vedotin. If the male participants are receiving
pembrolizumab only or undergoing surgery only, there are no contraception
requirements.

- A female participant is eligible to participate if she is not pregnant, not
breastfeeding, and at least 1 of the following conditions applies: Not a (woman of
childbearing potential) WOCBP or a WOCBP who agrees to use a highly effective
contraceptive method or be abstinent from heterosexual intercourse (as their preferred
and usual lifestyle) during the intervention period and for at least 120 days after
the last dose of pembrolizumab and at least 60 days after the last dose of enfortumab
vedotin. A female participant must agree not to donate eggs during this period as
well.

- A WOCBP must have a negative highly sensitive pregnancy test within 24 hours before
the first dose of study intervention.

Exclusion Criteria:

- Known additional non-urothelial malignancy that is progressing or has required active
treatment ≤3 years of study randomization, with certain exceptions

- ≥ N2 or M1 disease

- Received any prior systemic antineoplastic treatment for muscle-invasive bladder
cancer (MIBC)

- Received prior therapy with an anti-programmed cell death protein 1 (PD-1),
anti-programmed death-ligand 1 (PD-L1), or anti-programmed cell death 1 ligand 2
(PD-L2), or with an agent directed to another stimulatory or co-inhibitory T-cell
receptor

- Received prior systemic anticancer therapy including investigational agents within 3
years prior to randomization

- Received any prior radiotherapy to the bladder

- Received a partial cystectomy of the bladder to remove any non-muscle-invasive bladder
cancer (NMIBC) or MIBC

- Received a live vaccine within 30 days prior to the first dose of study drug

- Current participation in or participation in a study of an investigational agent or
use of an investigational device within 4 weeks prior to the first dose of study
intervention

- Ongoing sensory or motor neuropathy Grade 2 or higher

- Diagnosis of immunodeficiency or receipt of chronic systemic steroid therapy or any
other form of immunosuppressive therapy within 7 days prior the first dose of study
drug. Physiologic replacement doses of corticosteroids are permitted for participants
with adrenal insufficiency.

- Hypersensitivity to monoclonal antibodies (including pembrolizumab) and/or any of
their excipients

- Severe (≥ Grade 3) hypersensitivity to any enfortumab vedotin excipient contained in
the drug formulation of enfortumab vedotin

- Active keratitis or corneal ulcerations. Participants with superficial punctate
keratitis are allowed if the disorder is being adequately treated in the opinion of
the investigator.

- Active autoimmune disease that has required systemic therapy in past 2 years (i.e.,
with use of disease modifying agents, corticosteroids or immunosuppressive drugs).
Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency) is not considered a form
of systemic therapy and is allowed.

- History of uncontrolled diabetes

- History of (noninfectious) pneumonitis that required steroids, or current pneumonitis.

- Active infection requiring systemic therapy

- Has had an allogenic tissue/solid organ transplant
Show More

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Medical Director

Role: Study Director

Affiliation: Merck Sharp & Dohme Corp.

Overall Contact

Name: Toll Free Number

Phone: 1-888-577-8839

Email: Trialsites@merck.com

Link: Merck Oncology Clinical Trials Information

Locations

Facility Status Contact
Scripps MD Anderson ( Site 0010)
La Jolla, California 92037
United States
Recruiting Study Coordinator
858-554-8367
John Wayne Cancer Institute ( Site 0075)
Santa Monica, California 90404
United States
Recruiting Study Coordinator
310-582-7456
Georgetown University Medical Center ( Site 0022)
Washington, District of Columbia 20007
United States
Recruiting Study Coordinator
202-444-2198
Emory University ( Site 0006)
Atlanta, Georgia 30322
United States
Recruiting Study Coordinator
404-778-4823
Parkview Cancer Institute ( Site 0077)
Fort Wayne, Indiana 46845
United States
Recruiting Study Coordinator
260-266-9167
Indiana University Melvin and Bren Simon Comprehensive Cancer Center ( Site 0004)
Indianapolis, Indiana 46202
United States
Recruiting Study Coordinator
317-274-7477
Wichita Urology Group ( Site 0059)
Wichita, Kansas 67226
United States
Recruiting Study Coordinator
316-636-6141
Greater Baltimore Medical Center ( Site 0014)
Baltimore, Maryland 21204
United States
Recruiting Study Coordinator
443-849-3285
Morristown Medical Center ( Site 0015)
Morristown, New Jersey 07962
United States
Recruiting Study Coordinator
973-971-5373
The University of New Mexico Comprehensive Cancer Center ( Site 0045)
Albuquerque, New Mexico 87131
United States
Recruiting Study Coordinator
505-925-0421
New York University Perlmutter Cancer Center ( Site 0008)
New York, New York 10016
United States
Recruiting Study Coordinator
212-731-5820
Icahn School of Medicine at Mount Sinai ( Site 0031)
New York, New York 10029
United States
Recruiting Study Coordinator
212-659-5452
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0021)
Tulsa, Oklahoma 74146
United States
Recruiting Study Coordinator
918-505-3200
Abramson Cancer Center of the University of Pennsylvania ( Site 0074)
Philadelphia, Pennsylvania 19104
United States
Recruiting Study Coordinator
215-614-1842
Fox Chase Cancer Center ( Site 0055)
Philadelphia, Pennsylvania 19111
United States
Recruiting Study Coordinator
215-728-1133
Allegheny General Hospital ( Site 0048)
Pittsburgh, Pennsylvania 15212
United States
Recruiting Study Coordinator
412-359-8373
Carolina Urologic Research Center ( Site 0062)
Myrtle Beach, South Carolina 29572
United States
Recruiting Study Coordinator
8434491010257
Urology Associates [Nashville, TN] ( Site 0053)
Nashville, Tennessee 37209
United States
Recruiting Study Coordinator
615-250-9268
Vanderbilt University Medical Center ( Site 0017)
Nashville, Tennessee 37232
United States
Recruiting Study Coordinator
615-936-5173
Inova Schar Cancer Institute ( Site 0007)
Fairfax, Virginia 22031
United States
Recruiting Study Coordinator
571-472-0623
Charleston Area Medical Center ( Site 0023)
Charleston, West Virginia 25304
United States
Recruiting Study Coordinator
304-388-9944
Western Sydney Local Health District ( Site 1259)
Blacktown, New South Wales 2148
Australia
Recruiting Study Coordinator
+61411462609
Macquarie University ( Site 1251)
Macquarie Park, New South Wales 2109
Australia
Recruiting Study Coordinator
+61298123500
Cairns Base Hospital ( Site 1257)
Cairns, Queensland 4870
Australia
Recruiting Study Coordinator
+61742268085
Mater Misericordiae Ltd ( Site 1258)
South Brisbane, Queensland 4101
Australia
Recruiting Study Coordinator
+61731769289
Eastern Health ( Site 1255)
Box Hill, Victoria 3128
Australia
Recruiting Study Coordinator
+61398953585
Monash Health ( Site 1260)
Clayton, Victoria 3168
Australia
Recruiting Study Coordinator
+61395086161
UCL Saint-Luc - Oncologie Medicale ( Site 0357)
Bruxelles, Bruxelles-Capitale, Region De 1200
Belgium
Recruiting Study Coordinator
+3227649457
CHU UCL Namur Site de Godinne ( Site 0354)
Yvoir, Namur 5530
Belgium
Recruiting Study Coordinator
+3281423858
AZ Maria Middelares Gent ( Site 0353)
Gent, Oost-Vlaanderen 9000
Belgium
Recruiting Study Coordinator
+3292469522
Tom Baker Cancer Centre ( Site 0100)
Calgary, Alberta T2N 4N2
Canada
Recruiting Study Coordinator
4034762543
Silverado Resarch Inc. ( Site 0111)
Victoria, British Columbia V8T 2C1
Canada
Recruiting Study Coordinator
2505929998
Moncton Hospital - Horizon Health Network ( Site 0112)
Moncton, New Brunswick E1C 6Z8
Canada
Recruiting Study Coordinator
5068575076
Sunnybrook Research Institute ( Site 0110)
Toronto, Ontario M4N 3M5
Canada
Recruiting Study Coordinator
416480500082139
Princess Margaret Cancer Centre ( Site 0107)
Toronto, Ontario M5G 2M9
Canada
Recruiting Study Coordinator
4169462246
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0105)
Montreal, Quebec H1T 2M4
Canada
Recruiting Study Coordinator
51425234005853
CIUSSS de l'Estrie-CHUS ( Site 0106)
Sherbrooke, Quebec J1H 5N4
Canada
Recruiting Study Coordinator
819346111012827
Herlev og Gentofte Hospital. ( Site 0412)
Herlev, Hovedstaden 2730
Denmark
Recruiting Study Coordinator
+4538683494
Rigshospitalet University Hospital ( Site 0411)
Kobenhavn, Hovedstaden 2100
Denmark
Recruiting Study Coordinator
+4535458403
Odense Universitetshospital ( Site 0413)
Odense, Syddanmark 5000
Denmark
Recruiting Study Coordinator
+4524998173
Hopital de la Timone ( Site 0489)
Marseille, Bouches-du-Rhone 13005
France
Recruiting Study Coordinator
+3391387658
Centre Francois Baclesse ( Site 0459)
Caen, Calvados 14076
France
Recruiting Study Coordinator
+33231455002
Centre Georges Francois Leclerc ( Site 0488)
Dijon, Cote-d Or 21000
France
Recruiting Study Coordinator
+33380293761
CHU Jean Minjoz ( Site 0455)
Besancon, Doubs 25000
France
Recruiting Study Coordinator
+33370632403
Institut de Cancerologie du Gard - CHU Caremeau ( Site 0490)
Nimes, Gard 30029
France
Recruiting Study Coordinator
+33466683301
Institut Claudius Regaud IUCT Oncopole ( Site 0486)
Toulouse, Haute-Garonne 31059
France
Recruiting Study Coordinator
+33531155993
CHU de Montpellier - Hopital Saint-Eloi ( Site 0469)
Montpellier, Herault 34295
France
Recruiting Study Coordinator
+33467332309
C.H.R.U. de Rennes. Hopital de Pontchaillou ( Site 0492)
Rennes, Ille-et-Vilaine 35033
France
Recruiting Study Coordinator
+33299284270
Hopital Belle Isle ( Site 0452)
Metz, Moselle 57045
France
Recruiting Study Coordinator
+0357841650
C.H.U. Lyon Sud ( Site 0466)
Pierre Benite, Rhone 69310
France
Recruiting Study Coordinator
+33478864324
Institut Gustave Roussy ( Site 0487)
Villejuif, Val-de-Marne 94805
France
Recruiting Study Coordinator
+33142115348
CHU Cochin ( Site 0475)
Paris, 75014
France
Recruiting Study Coordinator
+33158411439
Hopital Europeen Georges Pompidou ( Site 0476)
Paris, 75015
France
Recruiting Study Coordinator
+33156093447
Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0549)
Tuebingen, Baden-Wurttemberg 72076
Germany
Recruiting Study Coordinator
+4970712987235
Klinikum der Universitaet Muenchen - Grosshadern ( Site 0548)
Muenchen, Bayern 81377
Germany
Recruiting Study Coordinator
+498944000
Universitaetsklinikum Bonn ( Site 0550)
Bonn, Nordrhein-Westfalen 53127
Germany
Recruiting Study Coordinator
+4922828714184
Universitaetsklinikum Magdeburg A.o.R. ( Site 0535)
Magdeburg, Sachsen-Anhalt 39120
Germany
Recruiting Study Coordinator
+493916715034
Universitaetsklinikum Carl Gustav Carus ( Site 0532)
Dresden, Sachsen 01307
Germany
Recruiting Study Coordinator
+493514582447
Vivantes Klinikum am Urban ( Site 0529)
Berlin, 10967
Germany
Recruiting Study Coordinator
+4930130226301
SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 1010)
Szeged, Csongrad 6720
Hungary
Recruiting Study Coordinator
+3662545405
Petz Aladar Megyei Oktato Korhaz ( Site 1012)
Gyor, Gyor-Moson-Sopron 9023
Hungary
Recruiting Study Coordinator
+36203310075
Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 1001)
Budapest, 1106
Hungary
Recruiting Study Coordinator
+36703815172
Debreceni Egyetem Klinikai Kozpont ( Site 1006)
Debrecen, 4032
Hungary
Recruiting Study Coordinator
+3652255585
Tallaght University Hospital ( Site 0734)
Dublin, D24 NR0A
Ireland
Recruiting Study Coordinator
+35314144259
University Hospital Waterford ( Site 0747)
Waterford, X91 ER8E
Ireland
Recruiting Study Coordinator
+35351848934
Meir Medical Center ( Site 0846)
Kfar Saba, Central 4428164
Israel
Recruiting Study Coordinator
+97297471606
Assaf Harofeh Medical Center ( Site 0848)
Zerifin, HaMerkaz 7030001
Israel
Recruiting Study Coordinator
+97289779715
Ha Emek Medical Center ( Site 0843)
Afula, HaTsafon 1834111
Israel
Recruiting Study Coordinator
+97246495723
Soroka Medical Center ( Site 0849)
Beer Sheva, Southern 8410101
Israel
Recruiting Study Coordinator
+972523514527
Sheba Medical Center ( Site 0844)
Ramat Gan, Tell Abib 5265601
Israel
Recruiting Study Coordinator
+97235302191
Sourasky Medical Center ( Site 0850)
Tel Aviv, Tell Abib 6423906
Israel
Recruiting Study Coordinator
+97236973413
Shaare Zedek Medical Center ( Site 0842)
Jerusalem, Yerushalayim 9103102
Israel
Recruiting Study Coordinator
+97226666331
Rambam Medical Center ( Site 0845)
Haifa, 3109601
Israel
Recruiting Study Coordinator
+97247776750
Hadassah Ein Kerem Medical Center ( Site 0841)
Jerusalem, 9112001
Israel
Recruiting Study Coordinator
+972505172315
Rabin Medical Center ( Site 0847)
Petach Tikva, 4941492
Israel
Recruiting Study Coordinator
+97239378074
A.O.U. Policlinico Vittorio Emanuele - Presidio Gaspare Rodolico ( Site 0559)
Catania, 95123
Italy
Recruiting Study Coordinator
+390953781518
Istituto Nazionale Studio e Cura dei Tumori ( Site 0551)
Milano, 20133
Italy
Recruiting Study Coordinator
+390223902402
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori ( Site 0552)
Napoli, 80131
Italy
Recruiting Study Coordinator
+39815903637
Fondazione Salvatore Maugeri IRCCS ( Site 0554)
Pavia, 27100
Italy
Recruiting Study Coordinator
+390382592265
Policlinico Gemelli di Roma ( Site 0558)
Roma, 00168
Italy
Recruiting Study Coordinator
+390458128116
National Cancer Center ( Site 1354)
Goyang-si, Kyonggi-do 10408
Korea, Republic of
Recruiting Study Coordinator
+82319201678
Seoul National University Bundang Hospital ( Site 1356)
Seongnam-si, Kyonggi-do 13620
Korea, Republic of
Recruiting Study Coordinator
+82317877351
Korea University Anam Hospital ( Site 1351)
Seoul, 02841
Korea, Republic of
Recruiting Study Coordinator
+821099288097
Seoul National University Hospital ( Site 1352)
Seoul, 03080
Korea, Republic of
Recruiting Study Coordinator
+82220720361
Asan Medical Center ( Site 1355)
Seoul, 05505
Korea, Republic of
Recruiting Study Coordinator
+82230103980
Samsung Medical Center ( Site 1353)
Seoul, 06351
Korea, Republic of
Recruiting Study Coordinator
+82234103557
Centro de Urologia Avanzada del Noreste S.A. de C.V. ( Site 0253)
Monterrey, Nuevo Leon 66269
Mexico
Recruiting Study Coordinator
+528180267452
Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. ( Site 0300)
Aguascalientes, 20010
Mexico
Recruiting Study Coordinator
+524494735100
Centro Estatal de Cancerologia de Chihuahua ( Site 0254)
Chihuahua, 31000
Mexico
Recruiting Study Coordinator
+526141420241
Instituto Nacional de Cancerologia. ( Site 0256)
Ciudad de Mexico, 14080
Mexico
Recruiting Study Coordinator
+5215514514014
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 1063)
Wroclaw, Dolnoslaskie 50-556
Poland
Recruiting Study Coordinator
+48601143281
Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 1068)
Bydgoszcz, Kujawsko-pomorskie 85-796
Poland
Recruiting Study Coordinator
+48605680944
Szpital Wojewodzki ( Site 1062)
Tarnow, Malopolskie 33-100
Poland
Recruiting Study Coordinator
+48602280826
Europejskie Centrum Zdrowia Otwock ( Site 1058)
Otwock, Mazowieckie 05-400
Poland
Recruiting Study Coordinator
+48227103025
Magodent Szpital Elblaska ( Site 1051)
Warszawa, Mazowieckie 01-748
Poland
Recruiting Study Coordinator
+48224308700
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku ( Site 1057)
Slupsk, Pomorskie 76-200
Poland
Recruiting Study Coordinator
+48598460705
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1061)
Bielsko-Biala, Slaskie 43-300
Poland
Recruiting Study Coordinator
+48606399091
Ivanovo Regional Oncology Dispensary ( Site 0852)
Ivanovo, Ivanovskaya Oblast 153040
Russian Federation
Recruiting Study Coordinator
+79106672833
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0861)
Krasnoyarsk, Krasnoyarskiy Kray 660133
Russian Federation
Recruiting Study Coordinator
+79135349316
Kursk Regional Clinical Oncology Dispensary ( Site 0854)
Kursk, Kurskaya Oblast 305524
Russian Federation
Recruiting Study Coordinator
+79103113475
Leningrad Regional Oncology Center ( Site 0868)
Saint Petersburg, Leningradskaya Oblast 188663
Russian Federation
Recruiting Study Coordinator
+79219410363
Central Clinical Hospital with outpatient Clinic ( Site 0856)
Moscow, Moskva 121359
Russian Federation
Recruiting Study Coordinator
+79031691379
Bayandin Murmansk Regional Clinical Hospital ( Site 0859)
Murmansk, Murmanskaya Oblast 183057
Russian Federation
Recruiting Study Coordinator
+79217252994
Volga District Medical Center Federal Medical and Biological Agency ( Site 0857)
Nizhny Novgorod, Nizhegorodskaya Oblast 603074
Russian Federation
Recruiting Study Coordinator
+78314216977
Omsk Clinical Oncology Dispensary ( Site 0865)
Omsk, Omskaya Oblast 644013
Russian Federation
Recruiting Study Coordinator
+79139885114
Clinical Hospital Saint Luka ( Site 0867)
St. Petersburg, Sankt-Peterburg 194044
Russian Federation
Recruiting Study Coordinator
+79817217460
Saratov State Medical University n.a. V.I.Razumovskiy ( Site 0866)
Saratov, Saratovskaya Oblast 410012
Russian Federation
Recruiting Study Coordinator
+79271233801
Hospital Universitario de Girona Doctor Josep Trueta ( Site 0700)
Girona, Gerona 17007
Spain
Recruiting Study Coordinator
+349722258284028
Hospital Universitario Quiron Madrid ( Site 0694)
Pozuelo de Alarcon, Madrid 28223
Spain
Recruiting Study Coordinator
+34914521987
Instituto Valenciano de Oncologia - IVO ( Site 0679)
Valencia, Valenciana, Comunitat 46009
Spain
Recruiting Study Coordinator
+34961114605
Hospital del Mar ( Site 0698)
Barcelona, 08003
Spain
Recruiting Study Coordinator
+34932483139
Hospital San Pedro de Alcantara ( Site 0697)
Caceres, 10003
Spain
Recruiting Study Coordinator
+34927256200
Hospital Universitario Ramon y Cajal ( Site 0691)
Madrid, 28034
Spain
Recruiting Study Coordinator
+34913368263
Hospital Universitario San Carlos ( Site 0678)
Madrid, 28040
Spain
Recruiting Study Coordinator
+34913303000ext7554
Hospital Universitario la Paz ( Site 0690)
Madrid, 28046
Spain
Recruiting Study Coordinator
+34912071138
Hospital de Nuestra Senora de Valme ( Site 0693)
Sevilla, 41014
Spain
Recruiting Study Coordinator
+34955015000
Onkologiska kliniken ( Site 1212)
Solna, Stockholms Lan 171 64
Sweden
Recruiting Study Coordinator
+4646768936655
Akademiska Sjukhuset ( Site 1211)
Uppsala, Uppsala Lan 751 85
Sweden
Recruiting Study Coordinator
+46186110000
Cancercentrum ( Site 1214)
Umea, Vasterbottens Lan 901 89
Sweden
Recruiting Study Coordinator
+46907853296
Ramathibodi Hospital. ( Site 1451)
Bangkok, Krung Thep Maha Nakhon 10400
Thailand
Recruiting Study Coordinator
+6622011671
Faculty of Medicine Siriraj Hospital ( Site 1452)
Bangkok, Krung Thep Maha Nakhon 10700
Thailand
Recruiting Study Coordinator
+6624194488
Maharaj Nakorn Chiangmai Hospital ( Site 1453)
Chiang Mai, 50200
Thailand
Recruiting Study Coordinator
+66539455324
Srinagarind Hospital ( Site 1454)
Khon Kaen, 40002
Thailand
Recruiting Study Coordinator
+6643363225
Hacettepe Universitesi Tıp Fakultesi ( Site 0931)
Ankara, 06100
Turkey
Recruiting Study Coordinator
+905327233093
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0930)
Istanbul, 34096
Turkey
Recruiting Study Coordinator
+905324167355
Medeniyet Universitesi Goztepe Egitim ve Arastirma Hastanesi ( Site 0926)
Istanbul, 34722
Turkey
Recruiting Study Coordinator
+905323430723
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0921)
Istanbul, 34899
Turkey
Recruiting Study Coordinator
+905333832234
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0929)
Konya, 42080
Turkey
Recruiting Study Coordinator
+905334150753
Sakarya Universitesi Tip Fakultesi ( Site 0933)
Sakarya, 54290
Turkey
Recruiting Study Coordinator
+905054785576
Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi ( Site 0924)
Trabzon, 61080
Turkey
Recruiting Study Coordinator
+905052292035
Cherkasy Regional Oncology Dispensary ( Site 0959)
Cherkasy, Cherkaska Oblast 18009
Ukraine
Recruiting Study Coordinator
+380501606360
MI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 0963)
Dnipropetrovsk, Dnipropetrovska Oblast 49005
Ukraine
Recruiting Study Coordinator
+380567134785
Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC ( Site 0951)
Dnipro, Dnipropetrovska Oblast 49102
Ukraine
Recruiting Study Coordinator
+380675625054
Regional Oncology Center of Kharkiv ( Site 0958)
Kharkiv, Kharkivska Oblast 61000
Ukraine
Recruiting Study Coordinator
+380508266088
Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 0969)
Kharkiv, Kharkivska Oblast 61037
Ukraine
Recruiting Study Coordinator
+380577387134
National Cancer Institute of the MoH of Ukraine ( Site 0962)
Kyiv, Kyivska Oblast 03022
Ukraine
Recruiting Study Coordinator
+380672365175
Kyiv City Clinical Oncology Center ( Site 0960)
Kyiv, Kyivska Oblast 03115
Ukraine
Recruiting Study Coordinator
+380667027558
Lviv Regional Clinical Hospital ( Site 0955)
Lviv, Lvivska Oblast 79000
Ukraine
Recruiting Study Coordinator
+380677280861
Lviv State Regional Oncological Center ( Site 0967)
Lviv, Lvivska Oblast 79031
Ukraine
Recruiting Study Coordinator
+380973317578
Kent and Canterbury Hospital ( Site 0733)
Canterbury, England CT1 3NG
United Kingdom
Recruiting Study Coordinator
+441227766877
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 0725)
London, London, City Of EC1A 7BE
United Kingdom
Recruiting Study Coordinator
+442078828505
Imperial College Healthcare NHS Trust ( Site 0745)
London, London, City Of W6 8RF
United Kingdom
Recruiting Study Coordinator
+442033117627
Western General Hospital ( Site 0749)
Edinburgh, Midlothian EH42XU
United Kingdom
Recruiting Study Coordinator
+441315372211
Royal Cornwall Hospital ( Site 0727)
Truro, TR1 3LJ
United Kingdom
Recruiting Study Coordinator
4418722500