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BRIEF TITLE: Intravesical Gemcitabine and MK-3475 (Pembrolizumab) in the Treatment of Patients With BCG-Unresponsive Non-Muscle Invasive Bladder Cancer

Phase II Trial of Intravesical Gemcitabine and MK-3475 (Pembrolizumab) in the Treatment of Patients With BCG-Unresponsive Non-Muscle Invasive Bladder Cancer


  • Org Study ID: NCI-2019-07573
  • Secondary ID: NCI-2019-07573,A031803,A031803,U10CA180821
  • NCT ID: NCT04164082
  • NCT Alias:
  • Sponsor: National Cancer Institute (NCI) - NIH
  • Source: National Cancer Institute (NCI)

Brief Summary

This phase II trial studies the effect of adding pembrolizumab to gemcitabine in treating patients with non-muscle invasive bladder cancer whose cancer does not respond to Bacillus Calmette-Guerin (BCG) treatment. Drugs used in chemotherapy, such as gemcitabine, work in different ways by stopping the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the patient's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Adding pembrolizumab to gemcitabine may delay the return of BCG-unresponsive bladder cancer for longer period compared to gemcitabine alone.

Detailed Description


PRIMARY OBJECTIVES:

I. Estimate the 6-month complete response rate of treatment with intravesical gemcitabine
hydrochloride (gemcitabine) in combination with MK-3475 (pembrolizumab) in patients with
Bacillus Calmette-Guerin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) that
have a carcinoma in situ (CIS) component.

II. Estimate the 18 month event-free survival (EFS) rate for all patients with
BCG-unresponsive NMIBC receiving intravesical gemcitabine in combination with pembrolizumab.

SECONDARY OBJECTIVES:

I. To characterize the safety profile of the combination of intravesical gemcitabine with
pembrolizumab with BCG-unresponsive NMIBC (CIS or high grade Ta and T1 with or without a CIS
component).

II. To estimate progression-free survival (PFS) of patients with BCG-unresponsive NMIBC
treated with intravesical gemcitabine in combination with pembrolizumab.

III. To estimate overall survival (OS) of patients with BCG-unresponsive NMIBC treated with
intravesical gemcitabine in combination with pembrolizumab.

IV. To estimate cystectomy-free survival of patients with BCG-unresponsive NMIBC treated with
intravesical gemcitabine in combination with pembrolizumab.

V. To estimate recurrence-free survival (RFS) for patients with a CIS component only and
those without a CIS component.

EXPLORATORY OBJECTIVES:

I. To assess correlation between tumor mutation burden (TMB) and EFS and 6-month complete
response (CR) rate.

II. To assess correlation between specific genomic alterations (single nucleotide variant
[SNV] and copy number gains/loss) and EFS and 6-month complete response rate.

III. To assess correlation between APOBEC mutational signature and EFS and 6-month complete
response rate.

IV. To assess correlation between immune gene signatures (IGS) and EFS and 6-month complete
response rate.

V. To assess correlation between PD-L1 ribonucleic acid (RNA) levels and EFS and 6-month
complete response rate.

VI. To assess correlation between RNA molecular subtype and EFS and 6-month complete response
rate.

VII. To assess correlation between intratumoral T-cell receptor (TCR) clonality and EFS and
6-month complete response rate.

VIII. To assess correlation between changes in peripheral blood TCR clonality and EFS and
6-month complete response rate.

IX. To assess EFS in patients with urine cell free deoxyribonucleic acid (DNA) (cfDNA) +
versus (vs.) patients with cfDNA.

OUTLINE:

INDUCTION: Patients receive pembrolizumab intravenously (IV) over 25-40 minutes on day 1 of
cycles 1-4. Patients also receive gemcitabine hydrochloride intravesically on days 1, 8 and
15 of cycles 1 and 2. Treatment repeats every 3 weeks for 4 cycles in the absence of disease
progression or unacceptable toxicity.

MAINTENANCE: Beginning cycle 5, patients with no evidence of disease after induction receive
pembrolizumab IV over 25-40 minutes and gemcitabine intravesically on day 1. Treatment
repeats every 3 weeks for 12 cycles in the absence of disease progression or unacceptable
toxicity.

After completion of study treatment or stop in study treatment for reasons other than
progression/recurrence or subsequent treatment, patients are followed every 3 months for 2
years and then every 6 months for up to 5 years from study registration or until disease
progression or recurrence. After documentation of disease progression or recurrence or
receiving non-protocol therapy, patients are followed every 6 months for up to 5 years total
from study registration. Patients who discontinue prior to starting any protocol treatment
(with or without progression) will go to survival follow-up, followed every 6 months for up
to 5 years from registration or until death, whichever comes first.

Overal Status Start Date Phase Study Type
Recruiting January 6, 2020 Phase 2 Interventional

Primary Outcomes:

Primary Outcome 1 - Measure: Complete response rate in the carcinoma in situ (CIS) subpopulation

Primary Outcome 1 - Time Frame: At 6 months (end of cycle 8, week 25)

Primary Outcome 2 - Measure: Event-free survival at 18 months

Primary Outcome 2 - Time Frame: From the date of study registration to the first documentation of an event or death whichever comes first, assessed up to 18 months

Condition:

  • Bladder Urothelial Carcinoma In Situ
  • Infiltrating Bladder Mixed Carcinoma
  • Stage 0a Bladder Cancer AJCC v8
  • Stage 0is Bladder Cancer AJCC v8
  • Stage I Bladder Cancer AJCC v8

Eligibility

Criteria:
Inclusion Criteria:

- High grade Ta, T1 or CIS urothelial carcinoma. Accrual of patients with Ta or T1
disease may be closed to ensure adequate patients enrollment to meet the primary
endpoint

- Persistent disease after completing therapy with at least induction BCG (>= 5 doses)
and the first round of maintenance or second induction course (>= 2 doses)

- Persistent high risk NMIBC (T1, high grade Ta and/or CIS) must be within 9 months
of the last BCG instillation despite having received adequate BCG as defined
above

- High grade T1 after completing therapy with at least induction BCG (>= 5 doses) or
after completing therapy with at least induction BCG (>=5 doses) and first round of
maintenance or second induction course (>= 2 doses)

- Persistent high risk NMIBC (T1, high grade Ta and/or CIS) must be within 9 months
of the last BCG instillation despite having received adequate BCG as defined
above

- Mixed variant histology (adenocarcinoma, squamous cell carcinoma) is eligible, but
pure variant histology is ineligible

- Patients who are disease free at 6 months after starting BCG but have high grade
recurrence (T1, Ta, CIS) while on maintenance therapy would be eligible

- The recurrence must be within 6 months of the last BCG dose

- Patients must be deemed unfit for radical cystectomy by the treating physician or
refuse radical cystectomy

- All visible tumor must be completely resected 60 days prior to registration (residual
pure CIS is permitted)

- All patients must have histologically confirmed urothelial cancer of the bladder
within 60 days prior to registration.

All patients must have had a cystoscopy without papillary tumor and negative urinary
cytology within 21 days of registration. (positive cytology is allowed in patients with
pure CIS)

- All patients with T1 tumors must undergo a re-staging transurethral resection of
bladder tumor (TURBT) within 60 days of registration. There must be uninvolved
muscularis propria present in the re-staging TURBT. The initial TURBT prior to
re-staging TURBT may be greater than 60 days prior to registration

- Patients must have had imaging with computed tomography (CT) or magnetic resonance
imaging (MRI) abdomen/pelvis within 90 days of registration demonstrating no evidence
of metastasis.

- Not pregnant and not nursing, because this study involves an agent that has known
genotoxic, mutagenic and teratogenic effects

- Therefore, for women of childbearing potential only, a negative pregnancy test
done =< 7 days prior to registration is required

- Eastern Cooperative Oncology Group (ECOG) performance status 0-2

- Absolute neutrophil count (ANC) >= 1,500/mm^3

- Platelet count >= 100,000/mm^3

- Hemoglobin >= 9.0 g/dL

- Creatinine =< 1.5 x upper limit of normal (ULN)

- In patients with creatinine > 1.5 x ULN, if measured or calculated creatinine
clearance > 30 mL/min, then patient is eligible

- Total Bilirubin =< 1.5 x ULN

- In patients with a total bilirubin > 1.5 x ULN, if direct bilirubin < 1.0 X ULN,
then patient is eligible

- Aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) =< 2.5 x ULN

- International normalized ratio (INR) or prothrombin time (PT) =< 1.5 x ULN

- Unless patient is receiving anticoagulant therapy, then PT or partial
thromboplastin time (PTT) must be within the therapeutic range of intended use of
the anticoagulant(s)

- Activated partial thromboplastin time (aPTT) =< 1.5 x ULN

- Unless patient is receiving anticoagulant therapy, then PT or PTT must be within
the therapeutic range of intended use of the anticoagulant(s)

- Patients with human immunodeficiency virus (HIV) are eligible with the following:

- On stable regimen of anti-retroviral therapy (highly active anti-retroviral
therapy [HAART]).

- No requirement for antibiotic or antifungal for prevention of opportunistic
infections.

- A CD4 count about 250 cells/mcl and undetectable HIV viral load by PCR

- Has no known additional malignancy that has had progression or has required active
treatment in the last three years. Exceptions include basal or squamous cell carcinoma
of the skin that has undergone potentially curative therapy or in situ cervical
cancer. A history of prostate cancer that was treated with definitive intent is
allowed, provided that the prostate-specific antigen (PSA) is undetectable for at
least 1 year while off androgen deprivation therapy

- No live vaccines or BCG within 30 days prior to registration

- Women and men of reproductive potential should agree to use an appropriate method of
birth control throughout their participation in this study due to the teratogenic
potential of the therapy utilized in this trial. Include as applicable: Appropriate
methods of birth control include abstinence, oral contraceptives, implantable hormonal
contraceptives or double barrier method (diaphragm plus condom).

Exclusion Criteria:

- Patients cannot have had a history of urothelial carcinoma in the ureters or prostatic
urethra 24 months prior to registration

- Patients must not have received any prior or concurrent systemic chemotherapy or
immunotherapy (prior intravesical chemotherapy and interferon is permitted). Single
dose chemotherapy post TURBT is permitted

- Patients must not have received any prior bladder radiation

- Patients must not have had an active autoimmune disease requiring systemic treatment
within 24 months prior to registration. Autoimmune diseases include, but not limited
to, lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease,
antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy,
Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis,
or glomerulonephritis

- Patients must not have undergone prior organ or bone marrow transplant

- Patients must not have active tuberculosis

- Patients must not have been treated with antibiotics for an active infection within 14
days prior to registration. Prophylactic antibiotics are permitted

- Patients must not have a history of idiopathic pulmonary fibrosis, pneumonitis,
organizing pneumonia, or active pneumonitis

- Patients must not have active hepatitis B or C (resolved disease with positive
anti-hepatitis B core [HBc] antibody or negative polymerase chain reaction [PCR] for
hepatitis C [HCV] RNA permitted)

- Glucocorticoids for any purpose other than to modulate symptoms from an adverse event
of suspected immunologic etiology. Physiologic doses of corticosteroids are allowed

- Physicians should consider whether any of the following may render the patient
inappropriate for this protocol:

- Psychiatric illness which would prevent the patient from giving informed consent.

- Medical condition such as uncontrolled infection, uncontrolled diabetes mellitus
or cardiac disease which, in the opinion of the treating physician, would make
this protocol unreasonably hazardous for the patient.
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Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Official Information

Name: Michael E Woods

Role: Principal Investigator

Affiliation: Alliance for Clinical Trials in Oncology

Locations

Facility Status Contact
Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Anchorage Radiation Therapy Center
Anchorage, Alaska 99504
United States
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907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Anchorage, Alaska 99508
United States
Recruiting Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Anchorage, Alaska 99508
United States
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907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Anchorage, Alaska 99508
United States
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907-212-6871
AKPAMC.OncologyResearchSupport@providence.org
Fairbanks Memorial Hospital
Fairbanks, Alaska 99701
United States
Recruiting Site Public Contact
907-458-3043
cancerresearch@foundationhealth.org
Mercy Hospital Fort Smith
Fort Smith, Arkansas 72903
United States
Recruiting Site Public Contact
800-378-9373
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
United States
Recruiting Site Public Contact
818-847-4793
Najee.Boucher@providence.org
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
United States
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916-734-3089
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
United States
Recruiting Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org
The Medical Center of Aurora
Aurora, Colorado 80012
United States
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303-777-2663
ccrp@co-cancerresearch.org
Boulder Community Hospital
Boulder, Colorado 80301
United States
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303-777-2663
jbloomfield@co-cancerresearch.org
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
United States
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303-777-2663
ccrp@co-cancerresearch.org
Cancer Center of Colorado at Sloan's Lake
Denver, Colorado 80204
United States
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303-777-2663
National Jewish Health-Main Campus
Denver, Colorado 80206
United States
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877-225-5654
glicht@co-cancerresearch.org
The Women's Imaging Center
Denver, Colorado 80209
United States
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303-777-2663
ccrp@co-cancerresearch.org
Colorado Blood Cancer Institute
Denver, Colorado 80218
United States
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303-777-2663
ccrp@co-cancerresearch.org
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado 80218
United States
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303-777-2663
ccrp@co-cancerresearch.org
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado 80218
United States
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303-777-2663
ccrp@co-cancerresearch.org
SCL Health Saint Joseph Hospital
Denver, Colorado 80218
United States
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303-777-2663
ccrp@co-cancerresearch.org
Rocky Mountain Cancer Centers-Rose
Denver, Colorado 80220
United States
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303-777-2663
ccrp@co-cancerresearch.org
Rose Medical Center
Denver, Colorado 80220
United States
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303-777-2663
ccrp@co-cancerresearch.org
Western Surgical Care
Denver, Colorado 80220
United States
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303-777-2663
Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado 80113
United States
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303-777-2663
WSCR@westernstatesncorp.org
Swedish Medical Center
Englewood, Colorado 80113
United States
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303-777-2663
ccrp@co-cancerresearch.org
National Jewish Health-Western Hematology Oncology
Golden, Colorado 80401
United States
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303-777-2663
glicht@co-cancerresearch.org
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado 81501
United States
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303-777-2663
ccrp@co-cancerresearch.org
North Colorado Medical Center
Greeley, Colorado 80631
United States
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303-777-2663
ccrp@co-cancerresearch.org
Good Samaritan Medical Center
Lafayette, Colorado 80026
United States
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303-673-1622
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
United States
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303-777-2663
ccrp@co-cancerresearch.org
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado 80124
United States
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303-777-2663
ccrp@co-cancerresearch.org
Sky Ridge Medical Center
Lone Tree, Colorado 80124
United States
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303-777-2663
ccrp@co-cancerresearch.org
McKee Medical Center
Loveland, Colorado 80539
United States
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303-777-2663
ccrp@co-cancerresearch.org
National Jewish Health-Northern Hematology Oncology
Thornton, Colorado 80260
United States
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303-777-2663
glicht@co-cancerresearch.org
SCL Health Lutheran Medical Center
Wheat Ridge, Colorado 80033
United States
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303-777-2663
ccrp@co-cancerresearch.org
Holy Cross Hospital
Fort Lauderdale, Florida 33308
United States
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954-267-7750
Hawaii Cancer Care - Savio
'Aiea, Hawaii 96701
United States
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808-539-2273
Pali Momi Medical Center
'Aiea, Hawaii 96701
United States
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808-486-6000
Queen's Cancer Center - Pearlridge
'Aiea, Hawaii 96701
United States
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808-487-7447
The Cancer Center of Hawaii-Pali Momi
'Aiea, Hawaii 96701
United States
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808-678-9000
Hawaii Cancer Care Inc-POB II
Honolulu, Hawaii 96813
United States
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808-524-6115
Island Urology
Honolulu, Hawaii 96813
United States
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808-536-2306
virginia@cc.hawaii.edu
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii 96813
United States
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808-532-0315
Queen's Medical Center
Honolulu, Hawaii 96813
United States
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808-545-8548
Straub Clinic and Hospital
Honolulu, Hawaii 96813
United States
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808-522-4333
University of Hawaii Cancer Center
Honolulu, Hawaii 96813
United States
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808-586-2979
Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii 96817
United States
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808-536-4888
Kuakini Medical Center
Honolulu, Hawaii 96817
United States
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808-547-9816
Queen's Cancer Center - Kuakini
Honolulu, Hawaii 96817
United States
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808-531-8521
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii 96817
United States
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808-547-6881
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii 96826
United States
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808-983-6090
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii 96766
United States
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808-535-7960
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
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734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute
Boise, Idaho 83712
United States
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208-381-2774
eslinget@slhs.org
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
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734-712-3671
stephanie.couch@stjoeshealth.org
Kootenai Medical Center
Coeur d'Alene, Idaho 83814
United States
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406-969-6060
mccinfo@mtcancer.org
Walter Knox Memorial Hospital
Emmett, Idaho 83617
United States
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734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, Idaho 83619
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Idaho Urologic Institute-Meridian
Meridian, Idaho 83642
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, Idaho 83642
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Saint Alphonsus Medical Center-Nampa
Nampa, Idaho 83686
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, Idaho 83686
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Kootenai Cancer Center
Post Falls, Idaho 83854
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Kootenai Cancer Clinic
Sandpoint, Idaho 83864
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, Idaho 83301
United States
Recruiting Site Public Contact
208-381-8059
hallsc@slhs.org
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
United States
Recruiting Site Public Contact
618-457-5200
clinical.research@sih.net
SIH Cancer Institute
Carterville, Illinois 62918
United States
Recruiting Site Public Contact
618-985-3333
clinical.research@sih.net
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Recruiting Site Public Contact
815-285-7800
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Recruiting Site Public Contact
217-876-4740
rhamrick@dmhhs.org
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
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309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United States
Recruiting Site Public Contact
309-344-2831
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
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309-243-3605
andersonj@illinoiscancercare.com
Loyola University Medical Center
Maywood, Illinois 60153
United States
Recruiting Site Public Contact
708-226-4357
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois 60160
United States
Recruiting Site Public Contact
708-450-4554
Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
United States
Recruiting Site Public Contact
618-242-4600
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
United States
Recruiting Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Peoria, Illinois 61636
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Valley Radiation Oncology
Peru, Illinois 61354
United States
Recruiting Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Recruiting Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Recruiting Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
United States
Recruiting Site Public Contact
800-444-7541
Memorial Medical Center
Springfield, Illinois 62781
United States
Recruiting Site Public Contact
217-788-3528
Southwest Illinois Health Services LLP
Swansea, Illinois 62226
United States
Recruiting Site Public Contact
618-236-1000
lynns@thecancercenter.com
Reid Health
Richmond, Indiana 47374
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Memorial Hospital of South Bend
South Bend, Indiana 46601
United States
Recruiting Site Public Contact
800-284-7370
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
United States
Recruiting Site Public Contact
859-257-3379
East Jefferson General Hospital
Metairie, Louisiana 70006
United States
Recruiting Site Public Contact
504-210-3539
emede1@lsuhsc.edu
LSU Healthcare Network / Metairie Multi-Specialty Clinic
Metairie, Louisiana 70006
United States
Recruiting Site Public Contact
504-210-3539
emede1@lsuhsc.edu
Louisiana State University Health Science Center
New Orleans, Louisiana 70112
United States
Recruiting Site Public Contact
504-210-3539
emede1@lsuhsc.edu
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland 21061
United States
Recruiting Site Public Contact
410-553-8100
Mercy Medical Center
Springfield, Massachusetts 01104
United States
Recruiting Site Public Contact
413-748-9234
Hickman Cancer Center
Adrian, Michigan 49221
United States
Recruiting Site Public Contact
517-265-0116
Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Bronson Battle Creek
Battle Creek, Michigan 49017
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
IHA Hematology Oncology Consultants-Brighton
Brighton, Michigan 48114
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Brighton
Brighton, Michigan 48114
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
IHA Hematology Oncology Consultants-Canton
Canton, Michigan 48188
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Canton
Canton, Michigan 48188
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Caro Cancer Center
Caro, Michigan 48723
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
IHA Hematology Oncology Consultants-Chelsea
Chelsea, Michigan 48118
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Chelsea
Chelsea, Michigan 48118
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Ascension Saint John Hospital
Detroit, Michigan 48236
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan 48054
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan 48503
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Hurley Medical Center
Flint, Michigan 48503
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids, Michigan 49503
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Mercy Health Saint Mary's
Grand Rapids, Michigan 49503
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Academic Hematology Oncology Specialists
Grosse Pointe Woods, Michigan 48236
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan 48236
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods, Michigan 48236
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Kalamazoo, Michigan 49007
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Borgess Medical Center
Kalamazoo, Michigan 49048
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Sparrow Hospital
Lansing, Michigan 48912
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Hope Cancer Clinic
Livonia, Michigan 48154
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Mary Mercy Hospital
Livonia, Michigan 48154
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan 48044
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Macomb Township
Macomb, Michigan 48044
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan 48453
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan 48162
United States
Recruiting Site Public Contact
800-444-3561
Mercy Health Mercy Campus
Muskegon, Michigan 49444
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Lakeland Hospital Niles
Niles, Michigan 49120
United States
Recruiting Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan 49444
United States
Recruiting Site Public Contact
616-391-1230
connie.szczepanek@crcwm.org
21st Century Oncology-Pontiac
Pontiac, Michigan 48341
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Hope Cancer Center
Pontiac, Michigan 48341
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Oakland
Pontiac, Michigan 48341
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Spectrum Health Reed City Hospital
Reed City, Michigan 49677
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Great Lakes Cancer Management Specialists-Rochester Hills
Rochester Hills, Michigan 48309
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Ascension Saint Mary's Hospital
Saginaw, Michigan 48601
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan 49085
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan 48312
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Ascension Saint Joseph Hospital
Tawas City, Michigan 48764
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Munson Medical Center
Traverse City, Michigan 49684
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Advanced Breast Care Center PLLC
Warren, Michigan 48088
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan 48093
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Macomb Hematology Oncology PC
Warren, Michigan 48093
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Warren
Warren, Michigan 48093
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint John Macomb-Oakland Hospital
Warren, Michigan 48093
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Metro Health Hospital
Wyoming, Michigan 49519
United States
Recruiting Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, Michigan 48197
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Fairview Ridges Hospital
Burnsville, Minnesota 55337
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Cambridge Medical Center
Cambridge, Minnesota 55008
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Unity Hospital
Fridley, Minnesota 55432
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Health Partners Inc
Minneapolis, Minnesota 55454
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Monticello Cancer Center
Monticello, Minnesota 55362
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
New Ulm Medical Center
New Ulm, Minnesota 56073
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Northland Medical Center
Princeton, Minnesota 55371
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Regions Hospital
Saint Paul, Minnesota 55101
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
United Hospital
Saint Paul, Minnesota 55102
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Lakeview Hospital
Stillwater, Minnesota 55082
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Ridgeview Medical Center
Waconia, Minnesota 55387
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Rice Memorial Hospital
Willmar, Minnesota 56201
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Fairview Lakes Medical Center
Wyoming, Minnesota 55092
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri 63011
United States
Recruiting Site Public Contact
314-251-7058
Cox Cancer Center Branson
Branson, Missouri 65616
United States
Recruiting Site Public Contact
417-269-4520
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Recruiting Site Public Contact
573-334-2230
sfmc@sfmc.net
Southeast Cancer Center
Cape Girardeau, Missouri 63703
United States
Recruiting Site Public Contact
573-651-5550
University of Missouri - Ellis Fischel
Columbia, Missouri 65212
United States
Recruiting Site Public Contact
573-882-7440
Parkland Health Center - Farmington
Farmington, Missouri 63640
United States
Recruiting Site Public Contact
314-996-5569
Capital Region Southwest Campus
Jefferson City, Missouri 65109
United States
Recruiting Site Public Contact
573-632-4814
swooden@mail.crmc.org
Freeman Health System
Joplin, Missouri 64804
United States
Recruiting Site Public Contact
417-347-4030
LJCrockett@freemanhealth.com
Mercy Hospital Joplin
Joplin, Missouri 64804
United States
Recruiting Site Public Contact
417-556-3074
esmeralda.carrillo@mercy.net
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri 65401
United States
Recruiting Site Public Contact
573-458-8776
kaysmith@phelpshealth.org
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
United States
Recruiting Site Public Contact
573-458-6379
Heartland Regional Medical Center
Saint Joseph, Missouri 64506
United States
Recruiting Site Public Contact
816-271-7937
linda.schumacher@mymlc.com
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri 63109
United States
Recruiting Site Public Contact
314-353-1870
Mercy Hospital South
Saint Louis, Missouri 63128
United States
Recruiting Site Public Contact

janet.lesko@mercy.net
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
United States
Recruiting Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
United States
Recruiting Site Public Contact
314-251-7066
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Recruiting Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield, Missouri 65804
United States
Recruiting Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield, Missouri 65807
United States
Recruiting Site Public Contact
417-269-4520
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
Recruiting Site Public Contact
314-996-5569
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri 63127
United States
Recruiting Site Public Contact
314-996-5569
Mercy Hospital Washington
Washington, Missouri 63090
United States
Recruiting Site Public Contact
636-390-1600
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Recruiting Site Public Contact
800-996-2663
research@billingsclinic.org
Saint Vincent Healthcare
Billings, Montana 59101
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Saint Vincent Frontier Cancer Center
Billings, Montana 59102
United States
Recruiting Site Public Contact
800-648-6274
Bozeman Deaconess Hospital
Bozeman, Montana 59715
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana 59701
United States
Recruiting Site Public Contact
406-723-2621
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Great Falls Clinic
Great Falls, Montana 59405
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Kalispell Regional Medical Center
Kalispell, Montana 59901
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Missoula, Montana 59802
United States
Recruiting Site Public Contact
406-327-3118
amy.hanneman@providence.org
Community Medical Hospital
Missoula, Montana 59804
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Recruiting Site Public Contact
212-639-7592
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Recruiting Site Public Contact
212-639-7592
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United States
Recruiting Site Public Contact
212-639-7592
The Valley Hospital-Luckow Pavilion
Paramus, New Jersey 07652
United States
Recruiting Site Public Contact
201-634-5792
Neurosurgeons of New Jersey-Ridgewood
Ridgewood, New Jersey 07450
United States
Recruiting Site Public Contact
773-702-9171
protocols@AllianceNCTN.org
Valley Hospital
Ridgewood, New Jersey 07450
United States
Recruiting Site Public Contact
201-634-5792
cparish@valleyhealth.com
Valley Health System-Hematology/Oncology
Westwood, New Jersey 07675
United States
Recruiting Site Public Contact
773-702-9171
protocols@AllianceNCTN.org
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Recruiting Site Public Contact
212-639-7592
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Recruiting Site Public Contact
212-639-7592
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Recruiting Site Public Contact
212-639-7592
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
Recruiting Site Public Contact
212-639-7592
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Recruiting Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu
University of North Carolina-Hillsborough Campus
Hillsborough, North Carolina 27278
United States
Recruiting Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu
Indu and Raj Soin Medical Center
Beavercreek, Ohio 45431
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Saint Elizabeth Boardman Hospital
Boardman, Ohio 44512
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio 45459
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio 45236
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Miami Valley Hospital
Dayton, Ohio 45409
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Dayton Physician LLC-Miami Valley Hospital North
Dayton, Ohio 45415
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Armes Family Cancer Center
Findlay, Ohio 45840
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Blanchard Valley Hospital
Findlay, Ohio 45840
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Orion Cancer Care
Findlay, Ohio 45840
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Dayton Physicians LLC-Atrium
Franklin, Ohio 45005
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Dayton Physicians LLC-Wayne
Greenville, Ohio 45331
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Wayne Hospital
Greenville, Ohio 45331
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Greater Dayton Cancer Center
Kettering, Ohio 45409
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
First Dayton Cancer Care
Kettering, Ohio 45420
United States
Recruiting Site Public Contact
937-416-9270
clinical.trials@daytonncorp.org
Kettering Medical Center
Kettering, Ohio 45429
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio 43551
United States
Suspended
Springfield Regional Cancer Center
Springfield, Ohio 45504
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Springfield Regional Medical Center
Springfield, Ohio 45505
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Mercy Saint Anne Hospital
Toledo, Ohio 43623
United States
Suspended
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623
United States
Recruiting Site Public Contact
800-444-3561
Dayton Physicians LLC-Upper Valley
Troy, Ohio 45373
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Upper Valley Medical Center
Troy, Ohio 45373
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Saint Joseph Warren Hospital
Warren, Ohio 44484
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio 44501
United States
Recruiting Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Recruiting Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
United States
Recruiting Site Public Contact
405-752-3402
Saint Alphonsus Medical Center-Baker City
Baker City, Oregon 97814
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Saint Charles Health System
Bend, Oregon 97701
United States
Recruiting Site Public Contact
541-706-2909
nosall@stcharleshealthcare.org
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon 97015
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Bay Area Hospital
Coos Bay, Oregon 97420
United States
Recruiting Site Public Contact
541-269-8392
cherie.cox@bayareahospital.org
Providence Newberg Medical Center
Newberg, Oregon 97132
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Saint Alphonsus Medical Center-Ontario
Ontario, Oregon 97914
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Providence Portland Medical Center
Portland, Oregon 97213
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Recruiting Site Public Contact
503-215-2614
CanRsrchStudies@providence.org
Saint Charles Health System-Redmond
Redmond, Oregon 97756
United States
Recruiting Site Public Contact
541-706-2909
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania 18017
United States
Recruiting Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
United States
Recruiting Site Public Contact
570-422-1700
ann.foster@lvhn.org
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania 18201
United States
Recruiting Site Public Contact
570-501-1242
Ralph H Johnson VA Medical Center
Charleston, South Carolina 29401
United States
Recruiting Site Public Contact
843-789-7020
ashley.salvo@va.gov
University of Texas Medical Branch
Galveston, Texas 77555-0565
United States
Active, not recruiting
UTMB Cancer Center at Victory Lakes
League City, Texas 77573
United States
Active, not recruiting
Audie L Murphy VA Hospital
San Antonio, Texas 78229
United States
Recruiting Site Public Contact
877-469-5300
University of Texas Health Science Center at San Antonio
San Antonio, Texas 78229
United States
Recruiting Site Public Contact
210-450-3800
phoresearchoffice@uthscsa.edu
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork, Utah 84003
United States
Suspended
Sandra L Maxwell Cancer Center
Cedar City, Utah 84720
United States
Suspended
Logan Regional Hospital
Logan, Utah 84321
United States
Suspended
Intermountain Medical Center
Murray, Utah 84107
United States
Suspended
McKay-Dee Hospital Center
Ogden, Utah 84403
United States
Suspended
Utah Valley Regional Medical Center
Provo, Utah 84604
United States
Suspended
Riverton Hospital
Riverton, Utah 84065
United States
Suspended
Dixie Medical Center Regional Cancer Center
Saint George, Utah 84770
United States
Suspended
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah 84106
United States
Suspended
LDS Hospital
Salt Lake City, Utah 84143
United States
Suspended
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
MultiCare Auburn Medical Center
Auburn, Washington 98001
United States
Suspended
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
United States
Recruiting Site Public Contact
360-788-8238
lkey@peacehealth.org
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Providence Regional Cancer Partnership
Everett, Washington 98201
United States
Recruiting Site Public Contact
425-261-3529
marilyn.birchman@providence.org
MultiCare Gig Harbor Medical Park
Gig Harbor, Washington 98335
United States
Suspended
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
United States
Recruiting Site Public Contact
509-783-4637
research@kadlecmed.org
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
PeaceHealth Saint John Medical Center
Longview, Washington 98632
United States
Recruiting Site Public Contact
360-514-2016
kmakin-bond@peacehealth.org
Jefferson Healthcare
Port Townsend, Washington 98368
United States
Recruiting Site Public Contact
360-344-3091
MultiCare Good Samaritan Hospital
Puyallup, Washington 98372
United States
Suspended
Pacific Gynecology Specialists
Seattle, Washington 98104
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Seattle, Washington 98122-4307
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
United States
Recruiting Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org
PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
United States
Recruiting Site Public Contact
360-788-8238
lkey@peacehealth.org
Providence Regional Cancer System-Shelton
Shelton, Washington 98584
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Spokane Valley, Washington 99216
United States
Suspended
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Spokane, Washington 99204
United States
Suspended
MultiCare Deaconess Cancer and Blood Specialty Center - North
Spokane, Washington 99218
United States
Suspended
MultiCare Tacoma General Hospital
Tacoma, Washington 98405
United States
Suspended
PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
United States
Recruiting Site Public Contact
360-514-3940
kmakin-bond@peacehealth.org
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
United States
Recruiting Site Public Contact
509-897-5993
Cheryl.Dodd@providence.org
Providence Regional Cancer System-Yelm
Yelm, Washington 98597
United States
Recruiting Site Public Contact
360-412-8958
deidre.dillon@providence.org
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Recruiting Site Public Contact
414-805-3666
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
Recruiting Site Public Contact

research.institute@phci.org
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
Recruiting Site Public Contact
952-993-1517
mmcorc@healthpartners.com
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Recruiting Site Public Contact
262-928-7878
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
United States
Recruiting Site Public Contact
262-928-7632
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
Recruiting Site Public Contact
262-928-5539
Chanda.miller@phci.org
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming 82001
United States
Recruiting Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org
Billings Clinic-Cody
Cody, Wyoming 82414
United States
Recruiting Site Public Contact
800-996-2663
research@billingsclinic.org
Welch Cancer Center
Sheridan, Wyoming 82801
United States
Recruiting Site Public Contact
406-969-6060
mccinfo@mtcancer.org
Cancer Center-Metro Medical Center Bayamon
Bayamon, 00959-5060
Puerto Rico
Recruiting Site Public Contact
787-395-7085
HIMA San Pablo Oncologic Hospital
Caguas, 00726
Puerto Rico
Recruiting Site Public Contact
787-653-3434
Doctors Cancer Center
Manati, 00674
Puerto Rico
Recruiting Site Public Contact
787-621-4397
Instituto Oncologia Moderna Ponce
Ponce, 00716
Puerto Rico
Recruiting Site Public Contact
787-848-0606
San Juan Community Oncology Group
San Juan, 00917
Puerto Rico
Recruiting Site Public Contact
787-274-3387
Centro Comprensivo de Cancer de UPR
San Juan, 00927
Puerto Rico
Recruiting Site Public Contact
888-823-5923
ctsucontact@westat.com
San Juan City Hospital
San Juan, 00936
Puerto Rico
Recruiting Site Public Contact
787-763-1296